GPR40 activation initiates store-operated Ca2+ entry and potentiates insulin secretion via the IP3R1/STIM1/Orai1 pathway in pancreatic β-cells

The long-chain fatty acid receptor GPR40 plays an important role in potentiation of glucose-induced insulin secretion (GIIS) from pancreatic β-cells. Previous studies demonstrated that GPR40 activation enhances Ca 2+ release from the endoplasmic reticulum (ER) by activating inositol 1,4,5-triphospha...

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Bibliographic Details
Published in:	Scientific reports Vol. 9; no. 1; pp. 1 - 11
Main Authors:	Usui, Ryota, Yabe, Daisuke, Fauzi, Muhammad, Goto, Hisanori, Botagarova, Ainur, Tokumoto, Shinsuke, Tatsuoka, Hisato, Tahara, Yumiko, Kobayashi, Shizuka, Manabe, Toshiya, Baba, Yoshihiro, Kurosaki, Tomohiro, Herrera, Pedro Luis, Ogura, Masahito, Nagashima, Kazuaki, Inagaki, Nobuya
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 29.10.2019 Nature Publishing Group
Subjects:	13/89 14/28 631/443/319/1642 631/443/319/1642/137 64/60 Beta cells Calcium (intracellular) Calcium (reticular) Calcium channels Calcium influx Endoplasmic reticulum Humanities and Social Sciences Inositol 1,4,5-trisphosphate receptors Insulin Insulin secretion multidisciplinary Orai1 protein Pancreas Science Science (multidisciplinary) Secretion STIM1 protein
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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