Pesticide exposure and risk of monoclonal gammopathy of undetermined significance in the Agricultural Health Study

Pesticides are associated with excess risk of multiple myeloma, albeit inconclusively. We included 678 men (30-94 years) from a well-characterized prospective cohort of restricted-use pesticide applicators to assess the risk of monoclonal gammopathy of undetermined significance (MGUS). Serum samples...

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Vydané v:Blood Ročník 113; číslo 25; s. 6386
Hlavní autori: Landgren, Ola, Kyle, Robert A, Hoppin, Jane A, Beane Freeman, Laura E, Cerhan, James R, Katzmann, Jerry A, Rajkumar, S Vincent, Alavanja, Michael C
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 18.06.2009
Predmet:
Adult
Age Factors
Aged
Aged, 80 and over
Agricultural Workers' Diseases - chemically induced
Agricultural Workers' Diseases - epidemiology
Blood Protein Electrophoresis
Carbon Disulfide - adverse effects
Carbon Tetrachloride - adverse effects
Cohort Studies
Dieldrin - adverse effects
Electrophoresis, Agar Gel
Humans
Iowa - epidemiology
Male
Middle Aged
Nitriles - adverse effects
North Carolina - epidemiology
Occupational Exposure
Paraproteinemias - chemically induced
Paraproteinemias - epidemiology
Pesticides - adverse effects
Prevalence
Prospective Studies
Sampling Studies
North Carolina
Iowa
ISSN:1528-0020, 1528-0020
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Shrnutí:Pesticides are associated with excess risk of multiple myeloma, albeit inconclusively. We included 678 men (30-94 years) from a well-characterized prospective cohort of restricted-use pesticide applicators to assess the risk of monoclonal gammopathy of undetermined significance (MGUS). Serum samples from all subjects were analyzed by electrophoresis performed on agarose gel; samples with a discrete or localized band were subjected to immunofixation. Age-adjusted prevalence estimates of MGUS were compared with MGUS prevalence in 9469 men from Minnesota. Associations between pesticide exposures and MGUS prevalence were assessed by logistic regression models adjusted for age and education level. Among study participants older than 50 years (n = 555), 38 were found to have MGUS, yielding a prevalence of 6.8% (95% CI, 5.0%-9.3%). Compared with men from Minnesota, the age-adjusted prevalence of MGUS was 1.9-fold (95% CI, 1.3- to 2.7-fold) higher among male pesticide applicators. Among applicators, a 5.6-fold (95% CI, 1.9- to 16.6-fold), 3.9-fold (95% CI, 1.5- to 10.0-fold), and 2.4-fold (95% CI, 1.1- to 5.3-fold) increased risk of MGUS prevalence was observed among users of the chlorinated insecticide dieldrin, the fumigant mixture carbon-tetrachloride/carbon disulfide, and the fungicide chlorothalonil, respectively. In summary, the prevalence of MGUS among pesticide applicators was twice that in a population-based sample of men from Minnesota, adding support to the hypothesis that specific pesticides are causatively linked to myelomagenesis.
Bibliografia:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1528-0020
1528-0020
DOI:10.1182/blood-2009-02-203471