Developmental Relationships of Four Exhausted CD8 + T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms

CD8 T cell exhaustion is a major barrier to current anti-cancer immunotherapies. Despite this, the developmental biology of exhausted CD8 T cells (Tex) remains poorly defined, restraining improvement of strategies aimed at "re-invigorating" Tex cells. Here, we defined a four-cell-stage dev...

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Bibliographic Details
Published in:	Immunity (Cambridge, Mass.) Vol. 52; no. 5; p. 825
Main Authors:	Beltra, Jean-Christophe, Manne, Sasikanth, Abdel-Hakeem, Mohamed S, Kurachi, Makoto, Giles, Josephine R, Chen, Zeyu, Casella, Valentina, Ngiow, Shin Foong, Khan, Omar, Huang, Yinghui Jane, Yan, Patrick, Nzingha, Kito, Xu, Wei, Amaravadi, Ravi K, Xu, Xiaowei, Karakousis, Giorgos C, Mitchell, Tara C, Schuchter, Lynn M, Huang, Alexander C, Wherry, E John
Format:	Journal Article
Language:	English
Published:	United States 19.05.2020
Subjects:	Animals B7-H1 Antigen - genetics B7-H1 Antigen - immunology CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cells, Cultured Epigenesis, Genetic - genetics Epigenesis, Genetic - immunology Hepatocyte Nuclear Factor 1-alpha - genetics Hepatocyte Nuclear Factor 1-alpha - immunology Homeodomain Proteins - genetics Homeodomain Proteins - immunology Humans Immunotherapy - methods Mice, Inbred C57BL Neoplasms - genetics Neoplasms - immunology Neoplasms - therapy T-Box Domain Proteins - genetics T-Box Domain Proteins - immunology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Transcription, Genetic - genetics Transcription, Genetic - immunology T cell exhaustion lineage chronic infection CD8 cancer immunotherapy PD-1 blockade exhaustion Tox T-bet TCF1 epigenetics
ISSN:	1097-4180, 1097-4180
Online Access:	Get more information
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