A Multiplexed, Heterogeneous, and Adaptive Code for Navigation in Medial Entorhinal Cortex

Medial entorhinal grid cells display strikingly symmetric spatial firing patterns. The clarity of these patterns motivated the use of specific activity pattern shapes to classify entorhinal cell types. While this approach successfully revealed cells that encode boundaries, head direction, and runnin...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Vol. 94; no. 2; p. 375
Main Authors: Hardcastle, Kiah, Maheswaranathan, Niru, Ganguli, Surya, Giocomo, Lisa M
Format: Journal Article
Language:English
Published: United States 19.04.2017
Subjects:
Action Potentials - physiology
Animals
Entorhinal Cortex - physiology
Female
Head
Male
Mice, Inbred C57BL
Models, Neurological
Motor Activity - physiology
Neurons - physiology
Space Perception - physiology
Theta Rhythm - physiology
Multiplexed-coding
spatial navigation
entorhinal cortex
adaptive coding
computational models of spatial coding
encoding mode
tuning heterogeneity
ISSN:1097-4199, 1097-4199
Online Access:Get more information
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Summary:Medial entorhinal grid cells display strikingly symmetric spatial firing patterns. The clarity of these patterns motivated the use of specific activity pattern shapes to classify entorhinal cell types. While this approach successfully revealed cells that encode boundaries, head direction, and running speed, it left a majority of cells unclassified, and its pre-defined nature may have missed unconventional, yet important coding properties. Here, we apply an unbiased statistical approach to search for cells that encode navigationally relevant variables. This approach successfully classifies the majority of entorhinal cells and reveals unsuspected entorhinal coding principles. First, we find a high degree of mixed selectivity and heterogeneity in superficial entorhinal neurons. Second, we discover a dynamic and remarkably adaptive code for space that enables entorhinal cells to rapidly encode navigational information accurately at high running speeds. Combined, these observations advance our current understanding of the mechanistic origins and functional implications of the entorhinal code for navigation. VIDEO ABSTRACT.
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ISSN:1097-4199
1097-4199
DOI:10.1016/j.neuron.2017.03.025