Astrocyte Crosstalk in CNS Inflammation

Astrocytes control multiple processes in the nervous system in health and disease. It is now clear that specific astrocyte subsets or activation states are associated with specific genomic programs and functions. The advent of novel genomic technologies has enabled rapid progress in the characteriza...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Vol. 108; no. 4; p. 608
Main Authors: Linnerbauer, Mathias, Wheeler, Michael A, Quintana, Francisco J
Format: Journal Article
Language:English
Published: United States 25.11.2020
Subjects:
Animals
Astrocytes - physiology
Cell Communication - physiology
Central Nervous System - physiopathology
Humans
Inflammation - physiopathology
Models, Neurological
cell interactions
glial cells
trained immunity
neuroinflammation
astrocyte
multiple sclerosis
ISSN:1097-4199, 1097-4199
Online Access:Get more information
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Summary:Astrocytes control multiple processes in the nervous system in health and disease. It is now clear that specific astrocyte subsets or activation states are associated with specific genomic programs and functions. The advent of novel genomic technologies has enabled rapid progress in the characterization of astrocyte heterogeneity and its control by astrocyte interactions with other cells in the central nervous system (CNS). In this review, we provide an overview of the multifaceted roles of astrocytes in the context of CNS inflammation, highlighting recent discoveries on astrocyte subsets and their regulation. We explore mechanisms of crosstalk between astrocytes and other cells in the CNS in the context of neuroinflammation and neurodegeneration and discuss how these interactions shape pathological outcomes.
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ISSN:1097-4199
1097-4199
DOI:10.1016/j.neuron.2020.08.012