Pharmacological Activities for Morus alba L., Focusing on the Immunostimulatory Property from the Fruit Aqueous Extract

Depending on the extraction method, numerous compounds that have specific pharmacological effects can be obtained from M. alba L. There is a growing scientific interest in health problems related to aging. Efforts to develop safe immune-enhancing pharmaceuticals are increasing. This review aims to s...

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Vydáno v:Foods Ročník 10; číslo 8; s. 1966
Hlavní autoři: Chang, Bo-Yoon, Koo, Bong-Seong, Kim, Sung-Yeon
Médium: Journal Article
Jazyk:angličtina
Vydáno: Basel MDPI AG 23.08.2021
MDPI
Témata:
Acids
Aging
alkaloids
Antiinfectives and antibacterials
Antioxidants
Arthritis
Asthma
Biological activity
biomedical research
Cardiovascular diseases
Cell activation
Diabetes
Ethanol
Flavonoids
Food science
Fruits
Health problems
Immune response
Immune system
Immunity
immunity enhancement
immunostimulants
Immunostimulation
Immunosuppression
Inflammation
Innate immunity
Literature reviews
M. alba. L
macrophage
Macrophages
Medical research
methanol
Morus alba
neoplasms
pathogens
Pharmaceuticals
Pharmacology
Phenols
Physiology
Phytochemicals
Polyphenols
Polysaccharides
Review
Search engines
TLR4 protein
Toll-like receptors
Tumor suppression
ISSN:2304-8158, 2304-8158
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Abstract Depending on the extraction method, numerous compounds that have specific pharmacological effects can be obtained from M. alba L. There is a growing scientific interest in health problems related to aging. Efforts to develop safe immune-enhancing pharmaceuticals are increasing. This review aims to summarize and critically discuss the immunity enhancement effects and pharmaceutical efficacy of M. alba L. extracts. The scientific database search was conducted using Google Scholar, Web of Science, and PubMed until May 2021. Additional articles were identified and obtained from references in the retrieved articles. Ethanol or methanol extraction of various parts of M. alba L. identified a large amount of phenols and flavonoids, which are effective for immunosuppression, antioxidants, and cardiovascular diseases, and are antibacterial, and anticancer. Water extraction of M. alba L. enhanced the innate immune response based on immune cell activation. A polysaccharide and an alkaloid related to increased macrophage activity were isolated from M. alba L. fruit extracts. M. alba L. fruit water extracts primarily induced the production of pro-inflammatory substances, in model organisms, via TLR4 in immune cells. Water extracts have been shown to be effective in pathogen defense and tumor suppression by enhancing macrophage activity. Based on our literature review on the bioactivity of M. alba L. fruit extracts, particularly in relation to their immunity enhancement activity, we anticipate that M. alba-derived pharmaceuticals will have excellent potential in future medical research.
AbstractList Depending on the extraction method, numerous compounds that have specific pharmacological effects can be obtained from M. alba L. There is a growing scientific interest in health problems related to aging. Efforts to develop safe immune-enhancing pharmaceuticals are increasing. This review aims to summarize and critically discuss the immunity enhancement effects and pharmaceutical efficacy of M. alba L. extracts. The scientific database search was conducted using Google Scholar, Web of Science, and PubMed until May 2021. Additional articles were identified and obtained from references in the retrieved articles. Ethanol or methanol extraction of various parts of M. alba L. identified a large amount of phenols and flavonoids, which are effective for immunosuppression, antioxidants, and cardiovascular diseases, and are antibacterial, and anticancer. Water extraction of M. alba L. enhanced the innate immune response based on immune cell activation. A polysaccharide and an alkaloid related to increased macrophage activity were isolated from M. alba L. fruit extracts. M. alba L. fruit water extracts primarily induced the production of pro-inflammatory substances, in model organisms, via TLR4 in immune cells. Water extracts have been shown to be effective in pathogen defense and tumor suppression by enhancing macrophage activity. Based on our literature review on the bioactivity of M. alba L. fruit extracts, particularly in relation to their immunity enhancement activity, we anticipate that M. alba-derived pharmaceuticals will have excellent potential in future medical research.
Depending on the extraction method, numerous compounds that have specific pharmacological effects can be obtained from M. alba L. There is a growing scientific interest in health problems related to aging. Efforts to develop safe immune-enhancing pharmaceuticals are increasing. This review aims to summarize and critically discuss the immunity enhancement effects and pharmaceutical efficacy of M. alba L. extracts. The scientific database search was conducted using Google Scholar, Web of Science, and PubMed until May 2021. Additional articles were identified and obtained from references in the retrieved articles. Ethanol or methanol extraction of various parts of M. alba L. identified a large amount of phenols and flavonoids, which are effective for immunosuppression, antioxidants, and cardiovascular diseases, and are antibacterial, and anticancer. Water extraction of M. alba L. enhanced the innate immune response based on immune cell activation. A polysaccharide and an alkaloid related to increased macrophage activity were isolated from M. alba L. fruit extracts. M. alba L. fruit water extracts primarily induced the production of pro-inflammatory substances, in model organisms, via TLR4 in immune cells. Water extracts have been shown to be effective in pathogen defense and tumor suppression by enhancing macrophage activity. Based on our literature review on the bioactivity of M. alba L. fruit extracts, particularly in relation to their immunity enhancement activity, we anticipate that M. alba-derived pharmaceuticals will have excellent potential in future medical research.Depending on the extraction method, numerous compounds that have specific pharmacological effects can be obtained from M. alba L. There is a growing scientific interest in health problems related to aging. Efforts to develop safe immune-enhancing pharmaceuticals are increasing. This review aims to summarize and critically discuss the immunity enhancement effects and pharmaceutical efficacy of M. alba L. extracts. The scientific database search was conducted using Google Scholar, Web of Science, and PubMed until May 2021. Additional articles were identified and obtained from references in the retrieved articles. Ethanol or methanol extraction of various parts of M. alba L. identified a large amount of phenols and flavonoids, which are effective for immunosuppression, antioxidants, and cardiovascular diseases, and are antibacterial, and anticancer. Water extraction of M. alba L. enhanced the innate immune response based on immune cell activation. A polysaccharide and an alkaloid related to increased macrophage activity were isolated from M. alba L. fruit extracts. M. alba L. fruit water extracts primarily induced the production of pro-inflammatory substances, in model organisms, via TLR4 in immune cells. Water extracts have been shown to be effective in pathogen defense and tumor suppression by enhancing macrophage activity. Based on our literature review on the bioactivity of M. alba L. fruit extracts, particularly in relation to their immunity enhancement activity, we anticipate that M. alba-derived pharmaceuticals will have excellent potential in future medical research.
Author Koo, Bong-Seong
Kim, Sung-Yeon
Chang, Bo-Yoon
AuthorAffiliation 1 Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Jeonbuk, Iksan 54538, Korea; pama611@naver.com
2 ForBioKorea Co., Ltd., Geumcheon-gu, Seoul 08592, Korea; bskoo@forbio.co.kr
AuthorAffiliation_xml – name: 2 ForBioKorea Co., Ltd., Geumcheon-gu, Seoul 08592, Korea; bskoo@forbio.co.kr
– name: 1 Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Jeonbuk, Iksan 54538, Korea; pama611@naver.com
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  surname: Chang
  fullname: Chang, Bo-Yoon
– sequence: 2
  givenname: Bong-Seong
  surname: Koo
  fullname: Koo, Bong-Seong
– sequence: 3
  givenname: Sung-Yeon
  surname: Kim
  fullname: Kim, Sung-Yeon
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Snippet Depending on the extraction method, numerous compounds that have specific pharmacological effects can be obtained from M. alba L. There is a growing scientific...
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StartPage 1966
SubjectTerms Acids
Aging
alkaloids
Antiinfectives and antibacterials
Antioxidants
Arthritis
Asthma
Biological activity
biomedical research
Cardiovascular diseases
Cell activation
Diabetes
Ethanol
Flavonoids
Food science
Fruits
Health problems
Immune response
Immune system
Immunity
immunity enhancement
immunostimulants
Immunostimulation
Immunosuppression
Inflammation
Innate immunity
Literature reviews
M. alba. L
macrophage
Macrophages
Medical research
methanol
Morus alba
neoplasms
pathogens
Pharmaceuticals
Pharmacology
Phenols
Physiology
Phytochemicals
Polyphenols
Polysaccharides
Review
Search engines
TLR4 protein
Toll-like receptors
Tumor suppression
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Title Pharmacological Activities for Morus alba L., Focusing on the Immunostimulatory Property from the Fruit Aqueous Extract
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