Inducing Different Neuronal Subtypes from Astrocytes in the Injured Mouse Cerebral Cortex

Astrocytes are particularly promising candidates for reprogramming into neurons, as they maintain some of the original patterning information from their radial glial ancestors. However, to which extent the position of astrocytes influences the fate of reprogrammed neurons remains unknown. To elucida...

Full description

Saved in:

Bibliographic Details
Published in:	Neuron (Cambridge, Mass.) Vol. 103; no. 6; p. 1086
Main Authors:	Mattugini, Nicola, Bocchi, Riccardo, Scheuss, Volker, Russo, Gianluca Luigi, Torper, Olof, Lao, Chu Lan, Götz, Magdalena
Format:	Journal Article
Language:	English
Published:	United States 25.09.2019
Subjects:	Animals Astrocytes - cytology Astrocytes - metabolism Basic Helix-Loop-Helix Transcription Factors - genetics Brain Injuries, Traumatic Cellular Reprogramming Techniques - methods Cerebral Cortex - cytology Cerebral Cortex - injuries Dependovirus Genetic Vectors Gliosis Gray Matter - cytology Mice Nerve Tissue Proteins - genetics Neurons - cytology Neurons - metabolism Nuclear Receptor Subfamily 4, Group A, Member 2 - genetics Pyramidal Cells - cytology Pyramidal Cells - metabolism White Matter - cytology Wounds, Stab cortical layers reprogramming axonal projection cerebral cortex electrophysiology reactive gliosis inflammation AAV astrocytes lentivirus
ISSN:	1097-4199, 1097-4199
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!