A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

A large-scale RNA interference screen to discover genes involved in trastuzumab resistance in breast cancer identified only PTEN as a modulator of drug sensitivity. Oncogenic mutants of PIK3CA (activator of the same pathway and frequently mutated in breast cancer) also conferred resistance to trastu...

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Bibliographic Details
Published in:	Cancer cell Vol. 12; no. 4; p. 395
Main Authors:	Berns, Katrien, Horlings, Hugo M, Hennessy, Bryan T, Madiredjo, Mandy, Hijmans, E Marielle, Beelen, Karin, Linn, Sabine C, Gonzalez-Angulo, Ana Maria, Stemke-Hale, Katherine, Hauptmann, Michael, Beijersbergen, Roderick L, Mills, Gordon B, van de Vijver, Marc J, Bernards, René
Format:	Journal Article
Language:	English
Published:	United States 01.10.2007
Subjects:	Adult Aged Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Breast Neoplasms - drug therapy Breast Neoplasms - enzymology Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - mortality Cell Line, Tumor Class I Phosphatidylinositol 3-Kinases Cohort Studies Disease Progression Drug Resistance, Neoplasm - genetics Female Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic Humans Kaplan-Meier Estimate Middle Aged Mutation Oligonucleotide Array Sequence Analysis Patient Selection Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism Receptor, ErbB-2 - antagonists & inhibitors Receptor, ErbB-2 - metabolism RNA Interference RNA, Small Interfering - metabolism Signal Transduction - drug effects Signal Transduction - genetics Transduction, Genetic Trastuzumab Treatment Outcome
ISSN:	1535-6108
Online Access:	Get more information
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