Bmi1 regulates stem cells and proliferation and differentiation of committed cells in mammary epithelium

PolycombGroup (PcG) proteins are epigenetic silencers involved in maintaining cellular identity, and their deregulation can result in cancer [1]. Mice without the PcG gene Bmi1 are runted and suffer from progressive loss of hematopoietic and neural stem cells [2-4]. Here, we assess the effects of Bm...

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Vydáno v:	Current biology Ročník 18; číslo 14; s. 1094
Hlavní autoři:	Pietersen, Alexandra M, Evers, Bastiaan, Prasad, Asheeta A, Tanger, Ellen, Cornelissen-Steijger, Paulien, Jonkers, Jos, van Lohuizen, Maarten
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England 22.07.2008
Témata:	Animals Cell Differentiation - physiology Cell Proliferation Epithelial Cells - cytology Epithelial Cells - metabolism Female Mammary Glands, Animal - cytology Mammary Glands, Animal - growth & development Mammary Glands, Animal - metabolism Mammary Glands, Animal - transplantation Mice Mice, Knockout Nuclear Proteins - deficiency Nuclear Proteins - genetics Nuclear Proteins - physiology Polycomb Repressive Complex 1 Pregnancy Proto-Oncogene Proteins - deficiency Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - physiology Repressor Proteins - genetics Repressor Proteins - physiology Stem Cells - cytology Stem Cells - metabolism
ISSN:	0960-9822
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