TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision

TCF-1 is a key transcription factor in progenitor exhausted CD8 T cells (Tex). Moreover, this Tex cell subset mediates responses to PD-1 checkpoint pathway blockade. However, the role of the transcription factor TCF-1 in early fate decisions and initial generation of Tex cells is unclear. Single-cel...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Immunity (Cambridge, Mass.) Ročník 51; číslo 5; s. 840
Hlavní autoři:	Chen, Zeyu, Ji, Zhicheng, Ngiow, Shin Foong, Manne, Sasikanth, Cai, Zhangying, Huang, Alexander C, Johnson, John, Staupe, Ryan P, Bengsch, Bertram, Xu, Caiyue, Yu, Sixiang, Kurachi, Makoto, Herati, Ramin S, Vella, Laura A, Baxter, Amy E, Wu, Jennifer E, Khan, Omar, Beltra, Jean-Christophe, Giles, Josephine R, Stelekati, Erietta, McLane, Laura M, Lau, Chi Wai, Yang, Xiaolu, Berger, Shelley L, Vahedi, Golnaz, Ji, Hongkai, Wherry, E John
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 19.11.2019
Témata:	Animals CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Differentiation - genetics Cell Differentiation - immunology Chronic Disease Gene Expression Profiling Gene Regulatory Networks Host-Pathogen Interactions - genetics Host-Pathogen Interactions - immunology Mice Programmed Cell Death 1 Receptor - metabolism T Cell Transcription Factor 1 - genetics T Cell Transcription Factor 1 - metabolism Transcription, Genetic Virus Diseases - genetics Virus Diseases - immunology Virus Diseases - virology chronic infection immunotherapy CD8 T cell exhaustion exhaustion cancer transcriptional circuit PD-1
ISSN:	1097-4180, 1097-4180
On-line přístup:	Zjistit podrobnosti o přístupu
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!