Infection of ferrets with wild type-based recombinant canine distemper virus overwhelms the immune system and causes fatal systemic disease

Canine distemper virus (CDV) causes systemic infection resulting in severe and often fatal disease in a large spectrum of animal host species. The virus is closely related to measles virus and targets myeloid, lymphoid, and epithelial cells, but CDV is more virulent and the infection spreads more ra...

Full description

Saved in:

Bibliographic Details
Published in:	mSphere Vol. 8; no. 4; p. e0008223
Main Authors:	Laksono, Brigitta M., Roelofs, Dagmar, Comvalius, Anouskha D., Schmitz, Katharina S., Rijsbergen, Laurine C., Geers, Daryl, Nambulli, Sham, van Run, Peter, Duprex, W. Paul, van den Brand, Judith M. A., de Vries, Rory D., de Swart, Rik L.
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 24.08.2023
Subjects:	Animals Antibodies Antibody response Antigens Blood Brain Canine distemper canine distemper virus Central nervous system Disseminated infection Epithelial cells ferrets Flow cytometry Genomes Immune system Immunohistochemistry immunopathogenesis Infections Inflammation Lymphatic system Lymphocytes Lymphoid tissue morbillivirus Mortality Mustela Neurological complications Pathogenesis Proteins Systemic diseases Tropism Virulence Viruses Rhode Island United States > US Germany morbillivirus immunopathogenesis canine distemper virus ferrets
ISSN:	2379-5042, 2379-5042
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!