How many pathways for invasion of the red blood cell by the malaria parasite?

Merozoites of the malaria parasite Plasmodium falciparum use several receptors for cellular engagement when they invade human red blood cells. Recently, a merozoite erythrocyte-binding protein, EBA-140, has been identified that specifically binds to glycophorin C on red blood cells. Up to 50% of Mel...

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Vydáno v:	Trends in parasitology Ročník 19; číslo 10; s. 430 - 432
Hlavní autor:	Pasvol, Geoffrey
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Oxford Elsevier Ltd 01.10.2003 Elsevier
Témata:	Animals Antigens, Protozoan - genetics Antigens, Protozoan - metabolism Biological and medical sciences Carrier Proteins - genetics Carrier Proteins - metabolism Erythrocytes - metabolism Erythrocytes - parasitology Fundamental and applied biological sciences. Psychology Gene Deletion Glycophorin - metabolism Humans Life cycle. Host-agent relationship. Pathogenesis Melanesia Plasmodium falciparum - metabolism Plasmodium falciparum - pathogenicity Plasmodium falciparum - physiology Protein Binding Protozoa Protozoan Proteins - genetics Protozoan Proteins - metabolism Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Melanesia Human Protozoa Host parasite relation Apicomplexa Protozoal disease Malaria Red blood cell Parasite Parasitosis Invasion Infection Plasmodium falciparum Blood cell Biological receptor
ISSN:	1471-4922, 1471-5007
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Abstract	Merozoites of the malaria parasite Plasmodium falciparum use several receptors for cellular engagement when they invade human red blood cells. Recently, a merozoite erythrocyte-binding protein, EBA-140, has been identified that specifically binds to glycophorin C on red blood cells. Up to 50% of Melanesians have a deletion in this gene, and the resultant Gerbich-negative red blood cells are relatively resistant to invasion. While discovery of multiple pathways for invasion could confound the search for suitable vaccine targets, they could also be considered in the design of therapeutic interventions that prevent malaria parasites entering red blood cells.
AbstractList	Merozoites of the malaria parasite Plasmodium falciparum use several receptors for cellular engagement when they invade human red blood cells. Recently, a merozoite erythrocyte-binding protein, EBA-140, has been identified that specifically binds to glycophorin C on red blood cells. Up to 50% of Melanesians have a deletion in this gene, and the resultant Gerbich-negative red blood cells are relatively resistant to invasion. While discovery of multiple pathways for invasion could confound the search for suitable vaccine targets, they could also be considered in the design of therapeutic interventions that prevent malaria parasites entering red blood cells. Merozoites of the malaria parasite Plasmodium falciparum use several receptors for cellular engagement when they invade human red blood cells. Recently, a merozoite erythrocyte-binding protein, EBA-140, has been identified that specifically binds to glycophorin C on red blood cells. Up to 50% of Melanesians have a deletion in this gene, and the resultant Gerbich-negative red blood cells are relatively resistant to invasion. While discovery of multiple pathways for invasion could confound the search for suitable vaccine targets, they could also be considered in the design of therapeutic interventions that prevent malaria parasites entering red blood cells. Merozoites of the malaria parasite Plasmodium falciparum use several receptors for cellular engagement when they invade human red blood cells. Recently, a merozoite erythrocyte-binding protein, EBA-140, has been identified that specifically binds to glycophorin C on red blood cells. Up to 50% of Melanesians have a deletion in this gene, and the resultant Gerbich-negative red blood cells are relatively resistant to invasion. While discovery of multiple pathways for invasion could confound the search for suitable vaccine targets, they could also be considered in the design of therapeutic interventions that prevent malaria parasites entering red blood cells.Merozoites of the malaria parasite Plasmodium falciparum use several receptors for cellular engagement when they invade human red blood cells. Recently, a merozoite erythrocyte-binding protein, EBA-140, has been identified that specifically binds to glycophorin C on red blood cells. Up to 50% of Melanesians have a deletion in this gene, and the resultant Gerbich-negative red blood cells are relatively resistant to invasion. While discovery of multiple pathways for invasion could confound the search for suitable vaccine targets, they could also be considered in the design of therapeutic interventions that prevent malaria parasites entering red blood cells.
Author	Pasvol, Geoffrey
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Cites_doi	10.1128/IAI.71.4.1856-1863.2003 10.1016/S0140-6736(82)90157-X 10.1182/blood.V97.2.551 10.1128/IAI.67.11.5784-5791.1999 10.1126/science.3901257 10.1074/jbc.M211446200 10.1056/NEJM197608052950602 10.1084/jem.20020750 10.1073/pnas.0730883100 10.1073/pnas.081075398 10.1084/jem.194.11.1571 10.1016/S0140-6736(84)91366-7 10.1093/emboj/cdg096 10.2174/1389450003349461 10.1046/j.1365-2958.2001.02484.x 10.1038/297064a0 10.1182/blood.V67.5.1519.1519 10.1126/science.8009226 10.1038/nm807 10.1182/blood-2002-10-3076 10.1126/science.803712 10.1016/S0166-6851(01)00428-5 10.1084/jem.169.5.1795
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SubjectTerms	Animals Antigens, Protozoan - genetics Antigens, Protozoan - metabolism Biological and medical sciences Carrier Proteins - genetics Carrier Proteins - metabolism Erythrocytes - metabolism Erythrocytes - parasitology Fundamental and applied biological sciences. Psychology Gene Deletion Glycophorin - metabolism Humans Life cycle. Host-agent relationship. Pathogenesis Melanesia Plasmodium falciparum - metabolism Plasmodium falciparum - pathogenicity Plasmodium falciparum - physiology Protein Binding Protozoa Protozoan Proteins - genetics Protozoan Proteins - metabolism Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism
Title	How many pathways for invasion of the red blood cell by the malaria parasite?
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