How many pathways for invasion of the red blood cell by the malaria parasite?

Merozoites of the malaria parasite Plasmodium falciparum use several receptors for cellular engagement when they invade human red blood cells. Recently, a merozoite erythrocyte-binding protein, EBA-140, has been identified that specifically binds to glycophorin C on red blood cells. Up to 50% of Mel...

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Bibliographic Details
Published in:Trends in parasitology Vol. 19; no. 10; pp. 430 - 432
Main Author: Pasvol, Geoffrey
Format: Journal Article
Language:English
Published: Oxford Elsevier Ltd 01.10.2003
Elsevier
Subjects:
Animals
Antigens, Protozoan - genetics
Antigens, Protozoan - metabolism
Biological and medical sciences
Carrier Proteins - genetics
Carrier Proteins - metabolism
Erythrocytes - metabolism
Erythrocytes - parasitology
Fundamental and applied biological sciences. Psychology
Gene Deletion
Glycophorin - metabolism
Humans
Life cycle. Host-agent relationship. Pathogenesis
Melanesia
Plasmodium falciparum - metabolism
Plasmodium falciparum - pathogenicity
Plasmodium falciparum - physiology
Protein Binding
Protozoa
Protozoan Proteins - genetics
Protozoan Proteins - metabolism
Receptors, Cell Surface - genetics
Receptors, Cell Surface - metabolism
Melanesia
Human
Protozoa
Host parasite relation
Apicomplexa
Protozoal disease
Malaria
Red blood cell
Parasite
Parasitosis
Invasion
Infection
Plasmodium falciparum
Blood cell
Biological receptor
ISSN:1471-4922, 1471-5007
Online Access:Get full text
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Summary:Merozoites of the malaria parasite Plasmodium falciparum use several receptors for cellular engagement when they invade human red blood cells. Recently, a merozoite erythrocyte-binding protein, EBA-140, has been identified that specifically binds to glycophorin C on red blood cells. Up to 50% of Melanesians have a deletion in this gene, and the resultant Gerbich-negative red blood cells are relatively resistant to invasion. While discovery of multiple pathways for invasion could confound the search for suitable vaccine targets, they could also be considered in the design of therapeutic interventions that prevent malaria parasites entering red blood cells.
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ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2003.08.005