How many pathways for invasion of the red blood cell by the malaria parasite?

Merozoites of the malaria parasite Plasmodium falciparum use several receptors for cellular engagement when they invade human red blood cells. Recently, a merozoite erythrocyte-binding protein, EBA-140, has been identified that specifically binds to glycophorin C on red blood cells. Up to 50% of Mel...

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Vydané v:	Trends in parasitology Ročník 19; číslo 10; s. 430 - 432
Hlavný autor:	Pasvol, Geoffrey
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Oxford Elsevier Ltd 01.10.2003 Elsevier
Predmet:	Animals Antigens, Protozoan - genetics Antigens, Protozoan - metabolism Biological and medical sciences Carrier Proteins - genetics Carrier Proteins - metabolism Erythrocytes - metabolism Erythrocytes - parasitology Fundamental and applied biological sciences. Psychology Gene Deletion Glycophorin - metabolism Humans Life cycle. Host-agent relationship. Pathogenesis Melanesia Plasmodium falciparum - metabolism Plasmodium falciparum - pathogenicity Plasmodium falciparum - physiology Protein Binding Protozoa Protozoan Proteins - genetics Protozoan Proteins - metabolism Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Melanesia Human Protozoa Host parasite relation Apicomplexa Protozoal disease Malaria Red blood cell Parasite Parasitosis Invasion Infection Plasmodium falciparum Blood cell Biological receptor
ISSN:	1471-4922, 1471-5007
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Shrnutí:	Merozoites of the malaria parasite Plasmodium falciparum use several receptors for cellular engagement when they invade human red blood cells. Recently, a merozoite erythrocyte-binding protein, EBA-140, has been identified that specifically binds to glycophorin C on red blood cells. Up to 50% of Melanesians have a deletion in this gene, and the resultant Gerbich-negative red blood cells are relatively resistant to invasion. While discovery of multiple pathways for invasion could confound the search for suitable vaccine targets, they could also be considered in the design of therapeutic interventions that prevent malaria parasites entering red blood cells.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1471-4922 1471-5007
DOI:	10.1016/j.pt.2003.08.005