Cardiac output response to exercise in patients before allogenic hematopoietic stem cell transplantation

Introduction High-dose chemotherapy for remission induction can induce cardiac toxicity prior to hematopoietic stem cell transplantation (HSCT). However, the details of cardiac function in patients undergoing HSCT are unclear, particularly during exercise. The aim of present study was to evaluate ca...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:International Journal of Clinical Oncology Jg. 23; H. 6; S. 1173 - 1177
Hauptverfasser: Yoshida, Shinya, Someya, Fujiko, Yahata, Tetsutaro
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Tokyo Springer Science and Business Media LLC 01.12.2018
Springer Japan
Springer Nature B.V
Schlagworte:
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Cancer Research
Cardiac Output
Cardiac Output - drug effects
Cardiac Output - physiology
Case-Control Studies
Chemotherapy
Electrocardiography
Exercise Test
Exercise Test - methods
Female
Heart rate
Hematologic Neoplasms
Hematologic Neoplasms - drug therapy
Hematologic Neoplasms - pathology
Hematopoietic Stem Cell Transplantation
Hematopoietic stem cells
Humans
Intolerance
Male
Medicine
Medicine & Public Health
Middle Aged
Oncology
Original Article
Patient Selection
Physical training
Remission
Stem cell transplantation
Stem cells
Surgical Oncology
Thorax
Toxicity
Young Adult
Cardiac output response
Allogenic hematopoietic stem cell transplantation
Exercise intolerance
Cardiac toxicity
ISSN:1341-9625, 1437-7772, 1437-7772
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Introduction High-dose chemotherapy for remission induction can induce cardiac toxicity prior to hematopoietic stem cell transplantation (HSCT). However, the details of cardiac function in patients undergoing HSCT are unclear, particularly during exercise. The aim of present study was to evaluate cardiac output responses to exercise in patients after high-dose chemotherapy before HSCT compared with in age-matched healthy controls. Methods Twenty-nine patients before HSCT (age 44.6 ± 15.2 years) and 13 controls (45.8 ± 16.0 years) performed the 6-min walk test (6MWT). Cardiac output (CO), stroke volume (SV), heart rate (HR), and cardiac index (CI) were continuously measured during the 6MWT using the noninvasive thoracic impedance method. Results No significant difference was observed in the six-minute walk distance (6MD) between the two groups. SV, CO, and CI both at rest and the end of the 6MWT in the patients were significantly lower, compared with the controls, but there was no significant difference in HR. In all subjects, the 6MD was positively correlated with SV, CO, CI, and HR after the 6MWT. Conclusion These findings suggest that cardiac output response to exercise indicates exercise intolerance, which may not be detected by 6MD in patients before HSCT.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:1341-9625
1437-7772
1437-7772
DOI:10.1007/s10147-018-1315-2