Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb

Regulatory T (Treg) cells are critical mediators of immune tolerance whose activity depends upon T cell receptor (TCR) and mTORC1 kinase signaling, but the mechanisms that dictate functional activation of these pathways are incompletely understood. Here, we showed that amino acids license Treg cell...

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Bibliographic Details
Published in:	Immunity (Cambridge, Mass.) Vol. 51; no. 6; p. 1012
Main Authors:	Shi, Hao, Chapman, Nicole M, Wen, Jing, Guy, Cliff, Long, Lingyun, Dhungana, Yogesh, Rankin, Sherri, Pelletier, Stephane, Vogel, Peter, Wang, Hong, Peng, Junmin, Guan, Kun-Liang, Chi, Hongbo
Format:	Journal Article
Language:	English
Published:	United States 17.12.2019
Subjects:	Animals Arginine - metabolism Cell Cycle Cell Differentiation - physiology Cell Line Humans Immune Tolerance - immunology Leucine - metabolism Lymphocyte Activation - immunology Mechanistic Target of Rapamycin Complex 1 - metabolism Mice Mice, Inbred C57BL Mice, Knockout Monomeric GTP-Binding Proteins - genetics Monomeric GTP-Binding Proteins - metabolism Ras Homolog Enriched in Brain Protein - genetics Ras Homolog Enriched in Brain Protein - metabolism Receptors, Antigen, T-Cell - immunology T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - immunology autoimmunity Rheb eTreg cells amino acids mTOR Treg cells metabolism RagB RagA
ISSN:	1097-4180, 1097-4180
Online Access:	Get more information
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