Metabolic engineering for enhanced oil in biomass

The world is hungry for energy. Plant oils in the form of triacylglycerol (TAG) are one of the most reduced storage forms of carbon found in nature and hence represent an excellent source of energy. The myriad of applications for plant oils range across foods, feeds, biofuels, and chemical feedstock...

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Bibliographic Details
Published in:	Progress in lipid research Vol. 74; no. C; pp. 103 - 129
Main Authors:	Vanhercke, Thomas, Dyer, John M., Mullen, Robert T., Kilaru, Aruna, Rahman, Md. Mahbubur, Petrie, James R., Green, Allan G., Yurchenko, Olga, Singh, Surinder P.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.04.2019 Elsevier
Subjects:	Biochemistry & Molecular Biology biofuels Biomass carbon energy fatty acid composition feedstocks mesocarp Metabolic Engineering Nutrition & Dietetics Oil oilseeds petroleum phytomass Plant lipid metabolism Plant Oils - metabolism triacylglycerols Triglycerides - metabolism HFA PDAT VLC-PUFAs G3P LACS L1L GRIK1 RbohD WRI1 Biomass OLE1 SRPPs DAcT DW EFAs MCFAs MGD1 FAE1 IAA ER T6P AGPase TGD DCR MAG Oil CoA FAH12 JA PGM MGDG Metabolic engineering OPDA DHA LDIP FIT2 ABC ATGL ABI ACCase IBA PDHC CGI-58 SDP1 Plant lipid metabolism BADC LDAPs LPAAT DGAT MGAT ACL CFAs DAG LEC RuBisCO ACP FUS3 PA PC SSU EPA FAS LDs TAG GPAT PAP
ISSN:	0163-7827, 1873-2194, 1873-2194
Online Access:	Get full text
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Summary:	The world is hungry for energy. Plant oils in the form of triacylglycerol (TAG) are one of the most reduced storage forms of carbon found in nature and hence represent an excellent source of energy. The myriad of applications for plant oils range across foods, feeds, biofuels, and chemical feedstocks as a unique substitute for petroleum derivatives. Traditionally, plant oils are sourced either from oilseeds or tissues surrounding the seed (mesocarp). Most vegetative tissues, such as leaves and stems, however, accumulate relatively low levels of TAG. Since non-seed tissues constitute the majority of the plant biomass, metabolic engineering to improve their low-intrinsic TAG-biosynthetic capacity has recently attracted significant attention as a novel, sustainable and potentially high-yielding oil production platform. While initial attempts predominantly targeted single genes, recent combinatorial metabolic engineering strategies have focused on the simultaneous optimization of oil synthesis, packaging and degradation pathways (i.e., ‘push, pull, package and protect’). This holistic approach has resulted in dramatic, seed-like TAG levels in vegetative tissues. With the first proof of concept hurdle addressed, new challenges and opportunities emerge, including engineering fatty acid profile, translation into agronomic crops, extraction, and downstream processing to deliver accessible and sustainable bioenergy.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 SC0016536 USDOE Office of Science (SC)
ISSN:	0163-7827 1873-2194 1873-2194
DOI:	10.1016/j.plipres.2019.02.002