Anxiety Cells in a Hippocampal-Hypothalamic Circuit

The hippocampus is traditionally thought to transmit contextual information to limbic structures where it acquires valence. Using freely moving calcium imaging and optogenetics, we show that while the dorsal CA1 subregion of the hippocampus is enriched in place cells, ventral CA1 (vCA1) is enriched...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Vol. 97; no. 3; p. 670
Main Authors: Jimenez, Jessica C, Su, Katy, Goldberg, Alexander R, Luna, Victor M, Biane, Jeremy S, Ordek, Gokhan, Zhou, Pengcheng, Ong, Samantha K, Wright, Matthew A, Zweifel, Larry, Paninski, Liam, Hen, René, Kheirbek, Mazen A
Format: Journal Article
Language:English
Published: United States 07.02.2018
Subjects:
Animals
Anxiety - physiopathology
Avoidance Learning
Basolateral Nuclear Complex - physiology
CA1 Region, Hippocampal - physiology
Conditioning, Classical
Fear
Hypothalamic Area, Lateral - physiology
Male
Memory
Mice, Inbred C57BL
Neural Pathways - physiology
Neurons - physiology
Optogenetics
ventral hippocampus
anxiety
calcium imaging
ISSN:1097-4199, 1097-4199
Online Access:Get more information
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Summary:The hippocampus is traditionally thought to transmit contextual information to limbic structures where it acquires valence. Using freely moving calcium imaging and optogenetics, we show that while the dorsal CA1 subregion of the hippocampus is enriched in place cells, ventral CA1 (vCA1) is enriched in anxiety cells that are activated by anxiogenic environments and required for avoidance behavior. Imaging cells defined by their projection target revealed that anxiety cells were enriched in the vCA1 population projecting to the lateral hypothalamic area (LHA) but not to the basal amygdala (BA). Consistent with this selectivity, optogenetic activation of vCA1 terminals in LHA but not BA increased anxiety and avoidance, while activation of terminals in BA but not LHA impaired contextual fear memory. Thus, the hippocampus encodes not only neutral but also valence-related contextual information, and the vCA1-LHA pathway is a direct route by which the hippocampus can rapidly influence innate anxiety behavior.
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ISSN:1097-4199
1097-4199
DOI:10.1016/j.neuron.2018.01.016