Thyroid dysfunction and autoantibodies during pregnancy as predictive factors of pregnancy complications and maternal morbidity in later life

Knowledge is scarce concerning the significance of thyroid dysfunction/antibodies during pregnancy in regard to pregnancy complications/later maternal morbidity. The aim of this study was to evaluate the association between maternal thyroid dysfunction/antibodies during pregnancy and pregnancy compl...

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Veröffentlicht in:The journal of clinical endocrinology and metabolism Jg. 95; H. 3; S. 1084
Hauptverfasser: Männistö, Tuija, Vääräsmäki, Marja, Pouta, Anneli, Hartikainen, Anna-Liisa, Ruokonen, Aimo, Surcel, Heljä-Marja, Bloigu, Aini, Järvelin, Marjo-Riitta, Suvanto, Eila
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.03.2010
Schlagworte:
Adolescent
Adult
Analysis of Variance
Autoantibodies - blood
Cohort Studies
Diabetes Mellitus - etiology
Female
Humans
Hypertension - etiology
Middle Aged
Pregnancy
Pregnancy Complications
Prospective Studies
Regression Analysis
Surveys and Questionnaires
Thyroid Diseases - blood
Thyroid Diseases - etiology
Thyroxine - blood
Triiodothyronine - blood
ISSN:1945-7197, 1945-7197
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Zusammenfassung:Knowledge is scarce concerning the significance of thyroid dysfunction/antibodies during pregnancy in regard to pregnancy complications/later maternal morbidity. The aim of this study was to evaluate the association between maternal thyroid dysfunction/antibodies during pregnancy and pregnancy complications or later maternal hypertension, diabetes, and thyroid disease. We studied a prospective population-based cohort, Northern Finland Birth Cohort 1986 (NFBC 1986), with follow-up of 20 yr. Medication and hospital discharge records were used to assess maternal morbidity to hypertension, diabetes, and thyroid diseases. The study consisted of mothers of NFBC 1986 with early pregnancy serum samples for thyroid function and antibody analyses (n = 5805). Mothers were grouped and compared according to these test results. We focused on preeclampsia and gestational diabetes during index pregnancy, later maternal hypertension, diabetes, and thyroid disease morbidity and total mortality. Thyroid dysfunction and antibodies were not associated with pregnancy complications. Overt hypothyroidism was associated with subsequent maternal thyroid disease [hazard ratio (HR) (95% confidence interval), 17.7 (7.8-40.6)] and diabetes [6.0 (2.2-16.4)]. Subclinical hypothyroidism [3.3 (1.6-6.9)], TPO-Ab-positivity [4.2 (2.3-7.4)], and TG-Ab-positivity [3.3 (1.9-6.0)] were also associated with later thyroid disease. No association was found between thyroid dysfunction/antibodies and hypertension or overall mortality. Thyroid dysfunction and antibodies during pregnancy seem to predict later thyroid disease. Overt hypothyroidism poses risk of diabetes.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1945-7197
1945-7197
DOI:10.1210/jc.2009-1904