Review of flavonoids: A diverse group of natural compounds with anti-Candida albicans activity in vitro

•Flavonoids are a subdivision of polyphenols, a versatile class of natural compounds that represent secondary metabolites from higher plants with several reported protective activities, such as antifungal.•Subclasses of flavonoids include: chalcones, flavones, isoflavones, flavanols, flavanones, fla...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Archives of oral biology Jg. 76; S. 76 - 83
Hauptverfasser: Seleem, Dalia, Pardi, Vanessa, Murata, Ramiro Mendonça
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Elsevier Ltd 01.04.2017
Schlagworte:
Advanced Basic Science
Antifungal activity
Antifungal Agents - pharmacology
Apoptosis - drug effects
Candida albicans - drug effects
Candidiasis, Oral - drug therapy
Cell Wall - drug effects
Dentistry
Drug resistance
Drug Resistance, Fungal
Flavonoids
Flavonoids - pharmacology
In Vitro Techniques
Microbial Sensitivity Tests
Oral candidiasis
Polyphenols
MABA
Antifungal activity
Flavonoids
SAR
MIC
IC50
Polyphenols
Oral candidiasis
Drug resistance
MIC50
50% inhibitory concentration
50% minimum inhibitory concentration
minimum inhibitory concentration
microplate alamar blue assay
structure activity relationship
ISSN:0003-9969, 1879-1506, 1879-1506
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:•Flavonoids are a subdivision of polyphenols, a versatile class of natural compounds that represent secondary metabolites from higher plants with several reported protective activities, such as antifungal.•Subclasses of flavonoids include: chalcones, flavones, isoflavones, flavanols, flavanones, flavonols, and anthocyanidins.•The antifungal activity of flavonoids against C. albicans in vitro were reported in the literature, among potent compounds were quercetin and myricetin (flavonols), baicalein (flavones), catechins (flavanols), and carvacrol (chalcones).•Mechanisms of action for antifungal effects of flavonoids included inhibition of efflux pump and induction of apoptosis (baicalein and sedonan A), cell wall damage (catechins), and cytoplasmic membrane disruption (carvacrol).•Plasma membrane transporters play a critical role in binding of flavonoids to plasma membrane and hence determine the bioavailability of flavonoids, applied as xenobiotics. Flavonoids are a subdivision of polyphenols, a versatile class of natural compounds that represent secondary metabolites from higher plants and are abundant in human diet. Various protective effects of flavonoids have been reported, including antimicrobial and antifungal activities. Due to the nature of oral candidiasis and the increased use of antifungal agents, several drug-resistant strains have emerged making it impractical to rely on one standard therapeutic regime. The aim of this review is to summarize the antifungal activity of some examples of the major subclasses of flavonoids in pure extract forms against C. albicans in vitro, as reported in literature over the past 10 years (2004–2015). In addition, this review outlines the potential mechanism of actions of flavonoids studied in vitro, which may contribute to a better understanding of flavonoids as multi-targets agents in the treatment and/or prevention of oral candidiasis in clinical settings.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0003-9969
1879-1506
1879-1506
DOI:10.1016/j.archoralbio.2016.08.030