Role played by Toll-like receptors 2 and 4 in lipoteichoic acid-induced lung inflammation and coagulation

The cell wall of Streptococcus pneumoniae consists of lipoteichoic acid (LTA), which is released when pneumococci are killed by either the host immune system or antibiotic treatment. Release of excessive amounts of LTA has been implicated in the toxic sequelae of severe gram-positive infection by vi...

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Bibliographic Details
Published in:	The Journal of infectious diseases Vol. 197; no. 2; p. 245
Main Authors:	Dessing, Mark C, Schouten, Marcel, Draing, Christian, Levi, Marcel, von Aulock, Sonja, van der Poll, Tom
Format:	Journal Article
Language:	English
Published:	United States 15.01.2008
Subjects:	Animals Blood Coagulation - immunology Blood Coagulation - physiology Female Inflammation - immunology Inflammation - physiopathology Lipopolysaccharide Receptors - metabolism Lipopolysaccharides - immunology Lipopolysaccharides - pharmacology Lung - immunology Lung - physiopathology Male Mice Mice, Inbred C57BL Mice, Knockout Specific Pathogen-Free Organisms Streptococcus pneumoniae - immunology Streptococcus pneumoniae - pathogenicity Teichoic Acids - immunology Teichoic Acids - pharmacology Toll-Like Receptor 2 - metabolism Toll-Like Receptor 4 - metabolism
ISSN:	0022-1899
Online Access:	Get more information
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