Responsiveness and minimal important difference of the urticaria control test
Short Summary This study demonstrates the responsiveness of the Urticaria Control Test (UCT). Changes of its score by 3 points or more reflect a clinically relevant change of disease control (minimal important difference).
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| Vydané v: | Journal of allergy and clinical immunology Ročník 140; číslo 6; s. 1710 - 1713.e11 |
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| Hlavní autori: | , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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United States
Elsevier Inc
01.12.2017
Elsevier Limited |
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| ISSN: | 0091-6749, 1097-6825, 1097-6825 |
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| Abstract | Short Summary This study demonstrates the responsiveness of the Urticaria Control Test (UCT). Changes of its score by 3 points or more reflect a clinically relevant change of disease control (minimal important difference). |
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| AbstractList | Short Summary This study demonstrates the responsiveness of the Urticaria Control Test (UCT). Changes of its score by 3 points or more reflect a clinically relevant change of disease control (minimal important difference). [...]a regular and standardized evaluation of disease control during the course of disease may help to guide treatment decisions, to back these decisions with a valid and reliable documentation, and to monitor treatment outcome. UCT score changes from baseline to follow-up correlated strongly with changes of the UAS7 (r = −0.63) and CU-Q2oL total score (r = −0.71), and showed a good correlation with changes in DLQI scores (r = −0.49) (see Table I, and see Fig E2 in this article's Online Repository at www.jacionline.org). [...]the UCT results also strongly correlated with changes in the patients' self-evaluation of their treatment efficacy and with the physicians' global assessment of the treatment response (see Tables E3 and E4 in this article's Online Repository at www.jacionline.org). In line with other investigator,10 we prefer the direct and patient anchor-based approach over the indirect distributional-criterion approach. [...]we prefer the results from the ROC curve analysis over the “mean change method” results, as the ROC curve analysis also includes subjects who did not improve in their disease control. Only 5 patients with stable disease (15%) exhibited an improvement of their UCT score by 3 points or more, that is, 85% are classified correctly as not meaningfully improved when a MID of 3 points is applied. Because the UCT score changes did not fulfil the criteria for normal distribution in this patient sample (P = .018, Shapiro-Wilk test), we also investigated the performance of the calculated SDC in this population. |
| Author | Ohanyan, Tatevik Schoepke, Nicole Weller, Karsten Bolukbasi, Bediha Zuberbier, Torsten Metz, Martin Maurer, Marcus Peveling-Oberhag, Adriane Hawro, Tomasz Staubach, Petra |
| Author_xml | – sequence: 1 givenname: Tatevik surname: Ohanyan fullname: Ohanyan, Tatevik organization: Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité–Universitätsmedizin Berlin, Berlin, Germany – sequence: 2 givenname: Nicole surname: Schoepke fullname: Schoepke, Nicole organization: Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité–Universitätsmedizin Berlin, Berlin, Germany – sequence: 3 givenname: Bediha surname: Bolukbasi fullname: Bolukbasi, Bediha organization: Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité–Universitätsmedizin Berlin, Berlin, Germany – sequence: 4 givenname: Martin surname: Metz fullname: Metz, Martin organization: Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité–Universitätsmedizin Berlin, Berlin, Germany – sequence: 5 givenname: Tomasz surname: Hawro fullname: Hawro, Tomasz organization: Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité–Universitätsmedizin Berlin, Berlin, Germany – sequence: 6 givenname: Torsten surname: Zuberbier fullname: Zuberbier, Torsten organization: Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité–Universitätsmedizin Berlin, Berlin, Germany – sequence: 7 givenname: Adriane surname: Peveling-Oberhag fullname: Peveling-Oberhag, Adriane organization: Department of Dermatology, University Medical Center Mainz, Mainz, Germany – sequence: 8 givenname: Petra surname: Staubach fullname: Staubach, Petra organization: Department of Dermatology, University Medical Center Mainz, Mainz, Germany – sequence: 9 givenname: Marcus surname: Maurer fullname: Maurer, Marcus organization: Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité–Universitätsmedizin Berlin, Berlin, Germany – sequence: 10 givenname: Karsten orcidid: 0000-0003-4437-0313 surname: Weller fullname: Weller, Karsten email: karsten.weller@charite.de organization: Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité–Universitätsmedizin Berlin, Berlin, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28625805$$D View this record in MEDLINE/PubMed |
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| Keywords | DLQI smallest detectable change UAS UCT PatGA chronic inducible urticaria PRO chronic spontaneous urticaria responsiveness Chronic Urticaria Quality of Life Questionnaire SD SDC disease activity physicians global assessment PhyGA CSU Urticaria MID CU-Q 2oL health-related quality of life CIndU Urticaria Control Test Urticaria Activity Score patient reported outcome Dermatology Life Quality Index omalizumab quality of life minimal important difference HR-QoL patients global assessment standard deviation |
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| Snippet | Short Summary This study demonstrates the responsiveness of the Urticaria Control Test (UCT). Changes of its score by 3 points or more reflect a clinically... [...]a regular and standardized evaluation of disease control during the course of disease may help to guide treatment decisions, to back these decisions with... |
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| SubjectTerms | Allergy and Immunology Dermatitis Disease control Licenses Patients Physicians Quality of life Urticaria |
| Title | Responsiveness and minimal important difference of the urticaria control test |
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