Blunted Social Reward Responsiveness Moderates the Effect of Lifetime Social Stress Exposure on Depressive Symptoms
Exposure to social stress is a well-established risk factor for the development and recurrence of depression. Reduced neural responsiveness to monetary reward has been associated with greater symptoms following stress exposure. However, it remains unclear whether reduced reward responsiveness serves...
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| Veröffentlicht in: | Frontiers in behavioral neuroscience Jg. 13; S. 178 |
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| Abstract | Exposure to social stress is a well-established risk factor for the development and recurrence of depression. Reduced neural responsiveness to monetary reward has been associated with greater symptoms following stress exposure. However, it remains unclear whether reduced reward responsiveness serves as a mediator or moderator of the effects of stress on internalizing symptoms or whether similar patterns emerge with responses to social reward. We addressed this issue by measuring lifetime stress exposure and event-related potentials (ERPs) to social reward in 231 emerging adults (
= 18.16,
= 0.41 years old). Participants completed the Stress and Adversity Inventory (STRAIN) to assess severity of lifetime stressors and self-report measures of current internalizing symptoms. In addition, participants completed the Island Getaway task in which the reward positivity (RewP) ERP was recorded in response to social acceptance, adjusting for responses to rejection (RewP residual). In this task, participants vote to accept or reject peers and receive reward/acceptance and rejection feedback. Stressors were divided into social and non-social stress severity scores. Analyses were conducted to test social reward responsiveness as a mediator or moderator of the effects of social and non-social stress on internalizing symptoms. Both social and non-social stress exposure over the life course predicted symptoms of depression (
s < 0.001) and social anxiety (
s < 0.002). The effect of social stress on depression was moderated by the residual RewP to social reward, adjusting for responses to social rejection (
=0.024), such that greater lifetime social stress exposure and a relatively blunted RewP to social reward were associated with greater depressive symptoms. Social reward responsiveness did not mediate effects of stress on internalizing symptoms. Reduced processing of social reward may be a vulnerability for depression that increases risk for symptoms following exposure to social stress. Blunted social reward responsiveness appears to be a relatively unique vulnerability for depression, rather than social anxiety. Results support the utility of ERP measures in measuring individual differences in social reward processing that can be applied to better understand neural processes involved in the development of depression, and highlight the importance of considering specific dimensions of stressful life experiences. |
|---|---|
| AbstractList | Exposure to social stress is a well-established risk factor for the development and recurrence of depression. Reduced neural responsiveness to monetary reward has been associated with greater symptoms following stress exposure. However, it remains unclear whether reduced reward responsiveness serves as a mediator or moderator of the effects of stress on internalizing symptoms or whether similar patterns emerge with responses to social reward. We addressed this issue by measuring lifetime stress exposure and event-related potentials (ERPs) to social reward in 231 emerging adults (M = 18.16, SD = 0.41 years old). Participants completed the Stress and Adversity Inventory (STRAIN) to assess severity of lifetime stressors and self-report measures of current internalizing symptoms. In addition, participants completed the Island Getaway task in which the reward positivity (RewP) ERP was recorded in response to social acceptance, adjusting for responses to rejection (RewP residual). In this task, participants vote to accept or reject peers and receive reward/acceptance and rejection feedback. Stressors were divided into social and non-social stress severity scores. Analyses were conducted to test social reward responsiveness as a mediator or moderator of the effects of social and non-social stress on internalizing symptoms. Both social and non-social stress exposure over the life course predicted symptoms of depression (ps < 0.001) and social anxiety (ps < 0.002). The effect of social stress on depression was moderated by the residual RewP to social reward, adjusting for responses to social rejection (p =0.024), such that greater lifetime social stress exposure and a relatively blunted RewP to social reward were associated with greater depressive symptoms. Social reward responsiveness did not mediate effects of stress on internalizing symptoms. Reduced processing of social reward may be a vulnerability for depression that increases risk for symptoms following exposure to social stress. Blunted social reward responsiveness appears to be a relatively unique vulnerability for depression, rather than social anxiety. Results support the utility of ERP measures in measuring individual differences in social reward processing that can be applied to better understand neural processes involved in the development of depression, and highlight the importance of considering specific dimensions of stressful life experiences. Exposure to social stress is a well-established risk factor for the development and recurrence of depression. Reduced neural responsiveness to monetary reward has been associated with greater symptoms following stress exposure. It remains unclear whether reduced reward responsiveness serves as a mediator or moderator of the effects of stress on internalizing symptoms or whether similar patterns emerge with responses to social reward. We addressed this issue by measuring lifetime stress exposure and event-related potentials (ERPs) to social reward in 231 emerging adults (M = 18.16, SD = 0.41 years). Participants completed the Stress and Adversity Inventory (STRAIN) to assess severity of lifetime stressors and self-report measures of current internalizing symptoms. In addition, participants completed the Island Getaway task in which the reward positivity (RewP) ERP was recorded in response to social acceptance, adjusting for responses to rejection (RewP residual). In this task, participants vote to accept or reject peers and receive reward/acceptance and rejection feedback. Stressors were divided into social and non-social stress severity scores. Analyses were conducted to test social reward responsiveness as a mediator or moderator of the effects of social and non-social stress on internalizing symptoms. Both social and non-social stress exposure over the life course predicted symptoms of dysphoria (ps < .001) and social anxiety (ps < .002). The effect of social stress on dysphoria was moderated by the residual RewP to social reward, adjusting for responses to social rejection (p = .024), such that greater lifetime social stress exposure and a relatively blunted RewP to social reward were associated with greater depressive symptoms. Social reward responsiveness did not mediate effects of stress on internalizing symptoms. Reduced processing of social reward may be a vulnerability for depression that increases risk for symptoms following exposure to social stress. Blunted social reward responsiveness appears to be a relatively unique vulnerability for depression, rather than social anxiety. Results support the utility of ERP measures in measuring individual differences in social reward processing that can be applied to better understand neural processes involved in the development of depression, and highlight the importance of considering specific dimensions of stressful life experiences. Exposure to social stress is a well-established risk factor for the development and recurrence of depression. Reduced neural responsiveness to monetary reward has been associated with greater symptoms following stress exposure. However, it remains unclear whether reduced reward responsiveness serves as a mediator or moderator of the effects of stress on internalizing symptoms or whether similar patterns emerge with responses to social reward. We addressed this issue by measuring lifetime stress exposure and event-related potentials (ERPs) to social reward in 231 emerging adults (M = 18.16, SD = 0.41 years old). Participants completed the Stress and Adversity Inventory (STRAIN) to assess severity of lifetime stressors and self-report measures of current internalizing symptoms. In addition, participants completed the Island Getaway task in which the reward positivity (RewP) ERP was recorded in response to social acceptance, adjusting for responses to rejection (RewP residual). In this task, participants vote to accept or reject peers and receive reward/acceptance and rejection feedback. Stressors were divided into social and non-social stress severity scores. Analyses were conducted to test social reward responsiveness as a mediator or moderator of the effects of social and non-social stress on internalizing symptoms. Both social and non-social stress exposure over the life course predicted symptoms of depression (ps < 0.001) and social anxiety (ps < 0.002). The effect of social stress on depression was moderated by the residual RewP to social reward, adjusting for responses to social rejection (p =0.024), such that greater lifetime social stress exposure and a relatively blunted RewP to social reward were associated with greater depressive symptoms. Social reward responsiveness did not mediate effects of stress on internalizing symptoms. Reduced processing of social reward may be a vulnerability for depression that increases risk for symptoms following exposure to social stress. Blunted social reward responsiveness appears to be a relatively unique vulnerability for depression, rather than social anxiety. Results support the utility of ERP measures in measuring individual differences in social reward processing that can be applied to better understand neural processes involved in the development of depression, and highlight the importance of considering specific dimensions of stressful life experiences.Exposure to social stress is a well-established risk factor for the development and recurrence of depression. Reduced neural responsiveness to monetary reward has been associated with greater symptoms following stress exposure. However, it remains unclear whether reduced reward responsiveness serves as a mediator or moderator of the effects of stress on internalizing symptoms or whether similar patterns emerge with responses to social reward. We addressed this issue by measuring lifetime stress exposure and event-related potentials (ERPs) to social reward in 231 emerging adults (M = 18.16, SD = 0.41 years old). Participants completed the Stress and Adversity Inventory (STRAIN) to assess severity of lifetime stressors and self-report measures of current internalizing symptoms. In addition, participants completed the Island Getaway task in which the reward positivity (RewP) ERP was recorded in response to social acceptance, adjusting for responses to rejection (RewP residual). In this task, participants vote to accept or reject peers and receive reward/acceptance and rejection feedback. Stressors were divided into social and non-social stress severity scores. Analyses were conducted to test social reward responsiveness as a mediator or moderator of the effects of social and non-social stress on internalizing symptoms. Both social and non-social stress exposure over the life course predicted symptoms of depression (ps < 0.001) and social anxiety (ps < 0.002). The effect of social stress on depression was moderated by the residual RewP to social reward, adjusting for responses to social rejection (p =0.024), such that greater lifetime social stress exposure and a relatively blunted RewP to social reward were associated with greater depressive symptoms. Social reward responsiveness did not mediate effects of stress on internalizing symptoms. Reduced processing of social reward may be a vulnerability for depression that increases risk for symptoms following exposure to social stress. Blunted social reward responsiveness appears to be a relatively unique vulnerability for depression, rather than social anxiety. Results support the utility of ERP measures in measuring individual differences in social reward processing that can be applied to better understand neural processes involved in the development of depression, and highlight the importance of considering specific dimensions of stressful life experiences. Exposure to social stress is a well-established risk factor for the development and recurrence of depression. Reduced neural responsiveness to monetary reward has been associated with greater symptoms following stress exposure. However, it remains unclear whether reduced reward responsiveness serves as a mediator or moderator of the effects of stress on internalizing symptoms or whether similar patterns emerge with responses to social reward. We addressed this issue by measuring lifetime stress exposure and event-related potentials (ERPs) to social reward in 231 emerging adults ( = 18.16, = 0.41 years old). Participants completed the Stress and Adversity Inventory (STRAIN) to assess severity of lifetime stressors and self-report measures of current internalizing symptoms. In addition, participants completed the Island Getaway task in which the reward positivity (RewP) ERP was recorded in response to social acceptance, adjusting for responses to rejection (RewP residual). In this task, participants vote to accept or reject peers and receive reward/acceptance and rejection feedback. Stressors were divided into social and non-social stress severity scores. Analyses were conducted to test social reward responsiveness as a mediator or moderator of the effects of social and non-social stress on internalizing symptoms. Both social and non-social stress exposure over the life course predicted symptoms of depression ( s < 0.001) and social anxiety ( s < 0.002). The effect of social stress on depression was moderated by the residual RewP to social reward, adjusting for responses to social rejection ( =0.024), such that greater lifetime social stress exposure and a relatively blunted RewP to social reward were associated with greater depressive symptoms. Social reward responsiveness did not mediate effects of stress on internalizing symptoms. Reduced processing of social reward may be a vulnerability for depression that increases risk for symptoms following exposure to social stress. Blunted social reward responsiveness appears to be a relatively unique vulnerability for depression, rather than social anxiety. Results support the utility of ERP measures in measuring individual differences in social reward processing that can be applied to better understand neural processes involved in the development of depression, and highlight the importance of considering specific dimensions of stressful life experiences. |
| Author | Weinberg, Anna Ethridge, Paige Shields, Grant S. Kujawa, Autumn Pegg, Samantha Slavich, George M. |
| AuthorAffiliation | 3 Center for Mind and Brain, University of California , Davis, Davis, CA , United States 1 Department of Psychology and Human Development, Vanderbilt University , Nashville, TN , United States 4 Department of Psychiatry and Biobehavioral Sciences, Cousins Center for Psychoneuroimmunology, University of California, Los Angeles , Los Angeles, CA , United States 2 Department of Psychology, McGill University , Montreal, QC , Canada |
| AuthorAffiliation_xml | – name: 1 Department of Psychology and Human Development, Vanderbilt University , Nashville, TN , United States – name: 2 Department of Psychology, McGill University , Montreal, QC , Canada – name: 3 Center for Mind and Brain, University of California , Davis, Davis, CA , United States – name: 4 Department of Psychiatry and Biobehavioral Sciences, Cousins Center for Psychoneuroimmunology, University of California, Los Angeles , Los Angeles, CA , United States |
| Author_xml | – sequence: 1 givenname: Samantha surname: Pegg fullname: Pegg, Samantha – sequence: 2 givenname: Paige surname: Ethridge fullname: Ethridge, Paige – sequence: 3 givenname: Grant S. surname: Shields fullname: Shields, Grant S. – sequence: 4 givenname: George M. surname: Slavich fullname: Slavich, George M. – sequence: 5 givenname: Anna surname: Weinberg fullname: Weinberg, Anna – sequence: 6 givenname: Autumn surname: Kujawa fullname: Kujawa, Autumn |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31447659$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.neubiorev.2007.04.016 10.1016/j.jad.2016.08.020 10.1177/1073191118790036 10.1097/CHI.0b013e3181886eab 10.1016/j.neuroscience.2012.12.010 10.1037/1040-3590.19.3.253 10.1016/j.psyneuen.2014.07.009 10.1037/0033-295X.109.4.679 10.1016/j.biopsych.2012.03.014 10.1176/ajp.156.6.837 10.1111/psyp.12370 10.1192/bjp.bp.110.080499 10.1016/j.neuroimage.2011.05.037 10.1176/appi.ajp.2018.17101124 10.1111/jcpp.12944 10.1016/0013-4694(83)90135-9 10.1176/appi.ajp.163.1.115 10.1111/psyp.12957 10.1146/annurev.clinpsy.1.102803.143938 10.1016/s0006-3223(01)01129-5 10.1016/j.ijpsycho.2017.11.001 10.1017/S0033291715000525 10.1017/S0033291719001557 10.1016/j.cortex.2007.08.013 10.1177/0098628316662768 10.1207/s15374424jccp3401_5 10.1111/j.1467-8721.2009.01636.x 10.1016/j.bpsc.2016.09.006 10.1111/psyp.12002 10.1002/da.22284 10.1016/j.dcn.2014.08.008 10.1016/j.bbi.2018.08.011 10.1111/j.1469-7610.2011.02477.x 10.1097/PSY.0000000000000534 10.1001/archpsyc.60.8.789 10.1176/appi.ajp.159.7.1133 10.1016/j.yfrne.2018.03.001 10.1017/S0033291712000207 10.1017/S0954579414001400 10.1080/15374410801955854 10.1521/jscp.2009.28.2.223 10.1111/psyp.12664 10.1016/j.ijpsycho.2018.01.011 10.1016/j.jad.2003.12.013 10.1016/j.biopsych.2015.05.010 10.1016/j.neuron.2014.12.055 10.1016/j.biopsych.2015.09.008 10.1016/j.biopsycho.2019.04.001 10.1176/appi.apj.2016.15121524 |
| ContentType | Journal Article |
| Copyright | 2019. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2019 Pegg, Ethridge, Shields, Slavich, Weinberg and Kujawa. 2019 Pegg, Ethridge, Shields, Slavich, Weinberg and Kujawa |
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| Keywords | social reward life stress depression event-related potentials neurophysiology electroencephalogram reward responsiveness |
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| References | Hayes (B16) 2017 Kendler (B21) 2006; 163 Kujawa (B31) 2019; 60 Carlson (B2) 2011; 57 Stasik-O’Brien (B49) 2018; 26 Forbes (B9) 2012; 53 Hammen (B13) 2005; 1 La Greca (B33) 2005; 34 Davey (B5) 2008; 32 Kujawa (B29) 2018; 132 Sandre (B40) 2019; 145 Hanson (B15) 2015; 78 Keren (B24) 2018; 175 Gratton (B12) 1983; 55 Watson (B51) 2007; 19 Kujawa (B27) 2014; 10 Ethridge (B8) 2018; 132 Hammen (B14) 2009; 18 Slavich (B43) 2016; 43 Ethridge (B7) 2017; 54 Kendler (B22) 2003; 60 Slavich (B46) 2018; 80 Bress (B1) 2015; 17 Goldstein (B11) 2019 Holroyd (B17) 2002; 109 Kendler (B20) 2002; 159 Slavich (B45) 2009; 28 Epel (B6) 2018; 49 Holroyd (B18) 2008; 44 Slavich (B47) 2014; 49 Kujawa (B28) 2017; 2 Kujawa (B30) 2016; 80 Swartz (B50) 2015; 85 Keenan (B19) 2008; 47 Nelson (B37) 2016; 173 Kessler (B26) 2010; 197 Starr (B48) 2008; 37 Nikolova (B38) 2012; 72 Chapman (B3) 2004; 82 McLaughlin (B34) 2014; 31 Silk (B42) 2012; 42 (B36) 2019 Kendler (B23) 1999; 156 Kessler (B25) 2001; 49 Corral-Frías (B4) 2015; 45 Meyer (B35) 2017; 54 Proudfit (B39) 2015; 50 Goff (B10) 2013; 249 Slavich (B44) 2019; 75 Kujawa (B32) 2013; 50 Setterfield (B41) 2016; 15 |
| References_xml | – volume: 32 start-page: 1 year: 2008 ident: B5 article-title: The emergence of depression in adolescence: development of the prefrontal cortex and the representation of reward. publication-title: Neurosci. Biobehav. Rev. doi: 10.1016/j.neubiorev.2007.04.016 – volume: 15 start-page: 372 year: 2016 ident: B41 article-title: Increased social anhedonia and reduced helping behaviour in young people with high depressive symptomatology. publication-title: J. Affect. Disord. doi: 10.1016/j.jad.2016.08.020 – volume: 26 start-page: 944 year: 2018 ident: B49 article-title: Clinical utility of the inventory of depression and anxiety symptoms (IDAS). publication-title: Assessment doi: 10.1177/1073191118790036 – volume: 47 start-page: 1433 year: 2008 ident: B19 article-title: Subthreshold symptoms of depression in preadolescent girls are stable and predictive of depressive disorders. publication-title: J. Am. Acad. Child Adolesc. Psychiatr. doi: 10.1097/CHI.0b013e3181886eab – volume: 249 start-page: 129 year: 2013 ident: B10 article-title: Reduced nucleus accumbens reactivity and adolescent depression following early-life stress. publication-title: Neuroscience doi: 10.1016/j.neuroscience.2012.12.010 – volume: 19 start-page: 253 year: 2007 ident: B51 article-title: Development and validation of the inventory of depression and anxiety symptoms (IDAS). publication-title: Psychol. Assess. doi: 10.1037/1040-3590.19.3.253 – volume: 49 start-page: 141 year: 2014 ident: B47 article-title: Endogenous opioid system influences depressive reactions to socially painful targeted rejection life events. publication-title: Psychoneuroendocrinology doi: 10.1016/j.psyneuen.2014.07.009 – volume: 109 start-page: 679 year: 2002 ident: B17 article-title: The neural basis of human error processing: reinforcement learning, dopamine, and error-related negativity. publication-title: Psychol. Rev. doi: 10.1037/0033-295X.109.4.679 – volume: 72 start-page: 157 year: 2012 ident: B38 article-title: Ventral striatum reactivity to reward and recent life stress interact to predict positive affect. publication-title: Biol. Psychiatr. doi: 10.1016/j.biopsych.2012.03.014 – volume: 156 start-page: 837 year: 1999 ident: B23 article-title: Causal relationship between stressful life events and the onset of major depression. publication-title: Am. J. Psychiatr. doi: 10.1176/ajp.156.6.837 – volume: 50 start-page: 449 year: 2015 ident: B39 article-title: The reward positivity: from basic research on reward to a biomarker for depression. publication-title: Psychophysiology doi: 10.1111/psyp.12370 – volume: 197 start-page: 378 year: 2010 ident: B26 article-title: Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys. publication-title: Br. J. Psychiatr. doi: 10.1192/bjp.bp.110.080499 – volume: 57 start-page: 1608 year: 2011 ident: B2 article-title: Ventral striatal and medial prefrontal BOLD activation is correlated with reward-related electrocortical activity: a combined ERP and fMRI study. publication-title: Neuroimage. doi: 10.1016/j.neuroimage.2011.05.037 – volume: 175 start-page: 1111 year: 2018 ident: B24 article-title: Reward processing in depression: a conceptual and meta-analytic review across fMRI and EEG studies. publication-title: Am. J. Psychiatr. doi: 10.1176/appi.ajp.2018.17101124 – volume: 60 start-page: 82 year: 2019 ident: B31 article-title: Reduced reward responsiveness moderates the effect of maternal depression on depressive symptoms in offspring: evidence across levels of analysis. publication-title: J. Child. Psychol. Psychiatr. doi: 10.1111/jcpp.12944 – volume: 55 start-page: 468 year: 1983 ident: B12 article-title: A new method for off-line removal of ocular artifact. publication-title: Electroencephalogr. Clin. Neurophysiol. doi: 10.1016/0013-4694(83)90135-9 – volume: 163 start-page: 115 year: 2006 ident: B21 article-title: Toward a comprehensive developmental model for major depression in men. publication-title: Am. J. Psychiatr. doi: 10.1176/appi.ajp.163.1.115 – volume: 54 start-page: 1786 year: 2017 ident: B7 article-title: Neural responses to social and monetary reward in early adolescence and emerging adulthood. publication-title: Psychophysiology doi: 10.1111/psyp.12957 – volume: 1 start-page: 293 year: 2005 ident: B13 article-title: Stress and depression. publication-title: Annu. Rev. Clin. Psychol. doi: 10.1146/annurev.clinpsy.1.102803.143938 – volume: 49 start-page: 1002 year: 2001 ident: B25 article-title: Mood disorders in children and adolescents: an epidemiologic perspective. publication-title: Biol. Psychiatr. doi: 10.1016/s0006-3223(01)01129-5 – volume: 132 start-page: 323 year: 2018 ident: B29 article-title: A longitudinal examination of event-related potentials sensitive to monetary reward and loss feedback from late childhood to middle adolescence. publication-title: Int. J. Psychophysiol. doi: 10.1016/j.ijpsycho.2017.11.001 – volume: 45 start-page: 2605 year: 2015 ident: B4 article-title: Stress-related anhedonia is associated with ventral striatum reactivity to reward and transdiagnostic psychiatric symptomatology. publication-title: Psychol. Med. doi: 10.1017/S0033291715000525 – year: 2019 ident: B11 article-title: Stressful life events moderate the effect of neural reward responsiveness in childhood on depressive symptoms in adolescence. publication-title: Psychol. Med. doi: 10.1017/S0033291719001557 – volume: 44 start-page: 548 year: 2008 ident: B18 article-title: Dorsal anterior cingulate cortex integrates reinforcement history to guide voluntary behavior. publication-title: Cortex. doi: 10.1016/j.cortex.2007.08.013 – volume: 43 start-page: 346 year: 2016 ident: B43 article-title: Life stress and health: a review of conceptual issues and recent findings. publication-title: Teach. Psychol. doi: 10.1177/0098628316662768 – volume: 34 start-page: 49 year: 2005 ident: B33 article-title: Adolescent peer relations, friendships, and romantic relationships: do they predict social anxiety and depression? publication-title: J. Clin. Child Adolesc. Psychol. doi: 10.1207/s15374424jccp3401_5 – volume: 18 start-page: 200 year: 2009 ident: B14 article-title: Adolescent depression: stressful interpersonal contexts and risk for recurrence. publication-title: Curr. Dir. Psychol. Sci. doi: 10.1111/j.1467-8721.2009.01636.x – year: 2017 ident: B16 publication-title: Introduction to Mediation, Moderation, and Conditional Process Analysis – volume: 2 start-page: 28 year: 2017 ident: B28 article-title: Vulnerability to depression in youth: advances from affective neuroscience. publication-title: Biol. Psychiatry. Cogn. Neurosci. Neuroimaging. doi: 10.1016/j.bpsc.2016.09.006 – volume: 50 start-page: 134 year: 2013 ident: B32 article-title: The feedback negativity reflects favorable compared to nonfavorable outcomes based on global, not local, alternatives. publication-title: Psychophyiology doi: 10.1111/psyp.12002 – volume: 31 start-page: 834 year: 2014 ident: B34 article-title: Amygdala response to negative stimuli predicts PTSD symptom onset following a terrorist attack. publication-title: Depress. Anxiety. doi: 10.1002/da.22284 – volume: 10 start-page: 140 year: 2014 ident: B27 article-title: Electrocortical reactivity to social feedback in youth: a pilot study of the Island getaway task. publication-title: Dev. Cogn. Neurosci. doi: 10.1016/j.dcn.2014.08.008 – volume: 75 start-page: 3 year: 2019 ident: B44 article-title: Stressnology: the primitive (and problematic) study of life stress exposure and pressing need for better measurement. publication-title: Brain. Behav. Immun. doi: 10.1016/j.bbi.2018.08.011 – volume: 53 start-page: 3 year: 2012 ident: B9 article-title: Altered reward function in adolescent depression: what, when, and how? publication-title: J. Child Psychol. Psychiatry. doi: 10.1111/j.1469-7610.2011.02477.x – volume: 80 start-page: 17 year: 2018 ident: B46 article-title: Assessing lifetime stress exposure using the stress and adversity inventory for adults (Adult STRAIN): an overview and initial validation. publication-title: Psychosom. Med. doi: 10.1097/PSY.0000000000000534 – volume: 60 start-page: 789 year: 2003 ident: B22 article-title: Life event dimensions of loss, humiliation, entrapment, and danger in the prediction of onsets of major depression and generalized anxiety. publication-title: Arch. Gen. Psychiatr. doi: 10.1001/archpsyc.60.8.789 – volume: 159 start-page: 1133 year: 2002 ident: B20 article-title: Toward a comprehensive developmental model for major depression in women. publication-title: Am. J. Psychiatr. doi: 10.1176/appi.ajp.159.7.1133 – volume: 49 start-page: 146 year: 2018 ident: B6 article-title: More than a feeling: a unified view of stress measurement for population science. publication-title: Front. Neuroendocrinol. doi: 10.1016/j.yfrne.2018.03.001 – volume: 42 start-page: 2095 year: 2012 ident: B42 article-title: Why do anxious children become depressed teenagers? the role of social evaluative threat and reward processing. publication-title: Psychol. Med. doi: 10.1017/S0033291712000207 – volume: 17 start-page: 1285 year: 2015 ident: B1 article-title: The stability of the feedback negativity and its relationship with depression during childhood and adolescence. publication-title: Dev. Psychopathol. doi: 10.1017/S0954579414001400 – volume: 37 start-page: 337 year: 2008 ident: B48 article-title: Differentiating interpersonal correlates of depressive symptoms and social anxiety in adolescence: implications for models of comorbidity. publication-title: J. Clin. Child. Adolesc. Psychol. doi: 10.1080/15374410801955854 – volume: 28 start-page: 223 year: 2009 ident: B45 article-title: Targeted rejection predicts hastened onset of major depression. publication-title: J. Soc. Clin. Psychol. doi: 10.1521/jscp.2009.28.2.223 – volume: 54 start-page: 114 year: 2017 ident: B35 article-title: Considering ERP difference scores as individual difference measures: issues with subtraction and alternative approaches. publication-title: Psychophysiology doi: 10.1111/psyp.12664 – volume: 132 start-page: 311 year: 2018 ident: B8 article-title: Psychometric properties of neural responses to monetary and social rewards across development. publication-title: Int. J. Psychophysiol. doi: 10.1016/j.ijpsycho.2018.01.011 – volume: 82 start-page: 217 year: 2004 ident: B3 article-title: Adverse childhood experiences and the risk of depressive disorders in adulthood. publication-title: J. Affect. Disord. doi: 10.1016/j.jad.2003.12.013 – volume: 78 start-page: 598 year: 2015 ident: B15 article-title: Blunted ventral striatum development in adolescence reflects emotional neglect and predicts depressive symptoms. publication-title: Biol. Psychiatr. doi: 10.1016/j.biopsych.2015.05.010 – volume: 85 start-page: 505 year: 2015 ident: B50 article-title: A neural biomarker of psychological vulnerability to future life stress. publication-title: Neuron doi: 10.1016/j.neuron.2014.12.055 – volume: 80 start-page: 381 year: 2016 ident: B30 article-title: Neural reactivity to emotional stimuli prospectively predicts the impact of a natural disaster on psychiatric symptoms in children. publication-title: Biol. Psychiatry. doi: 10.1016/j.biopsych.2015.09.008 – volume: 145 start-page: 31 year: 2019 ident: B40 article-title: Blunted neural response to appetitive images prospectively predicts symptoms of depression, and not anxiety, during the transition to university. publication-title: Biol. Psychol. doi: 10.1016/j.biopsycho.2019.04.001 – volume: 173 start-page: 1223 year: 2016 ident: B37 article-title: Blunted neural response to rewards as a prospective predictor of the development of depression in adolescent girls. publication-title: Am. J. Psychiatr. doi: 10.1176/appi.apj.2016.15121524 – year: 2019 ident: B36 publication-title: RDoC Matrix. |
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| SubjectTerms | Anxiety Biomarkers Brain research Child development electroencephalogram Event-related potentials life stress Mental depression neurophysiology Neuroscience Reinforcement reward responsiveness Risk factors Social interactions Social research social reward Stress |
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| Title | Blunted Social Reward Responsiveness Moderates the Effect of Lifetime Social Stress Exposure on Depressive Symptoms |
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