Mechanical Unloading in Heart Failure
Myocardial injury induces significant changes in ventricular structure and function at both the cellular and anatomic level, leading to ventricular remodeling and subsequent heart failure. Unloading left ventricular pressure has been studied in both the short-term and long-term settings, as a means...
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| Vydáno v: | Journal of the American College of Cardiology Ročník 72; číslo 5; s. 569 |
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| Hlavní autoři: | , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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United States
31.07.2018
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| ISSN: | 1558-3597, 1558-3597 |
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| Abstract | Myocardial injury induces significant changes in ventricular structure and function at both the cellular and anatomic level, leading to ventricular remodeling and subsequent heart failure. Unloading left ventricular pressure has been studied in both the short-term and long-term settings, as a means of preventing or reversing cardiac remodeling. In acute myocardial infarction, cardiac unloading is used to reduce oxygen demand and limit infarct size. Research has demonstrated the benefits of short-term unloading with mechanical circulatory support devices before reperfusion in the context of acute myocardial infarction with cardiogenic shock, and a confirmatory trial is ongoing. In chronic heart failure, ventricular unloading using mechanical circulatory support can reverse many of the cellular and anatomic changes that accompany ventricular remodeling. Ongoing research is evaluating the ability of left ventricular assist devices to promote myocardial recovery and remission from clinical heart failure. |
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| AbstractList | Myocardial injury induces significant changes in ventricular structure and function at both the cellular and anatomic level, leading to ventricular remodeling and subsequent heart failure. Unloading left ventricular pressure has been studied in both the short-term and long-term settings, as a means of preventing or reversing cardiac remodeling. In acute myocardial infarction, cardiac unloading is used to reduce oxygen demand and limit infarct size. Research has demonstrated the benefits of short-term unloading with mechanical circulatory support devices before reperfusion in the context of acute myocardial infarction with cardiogenic shock, and a confirmatory trial is ongoing. In chronic heart failure, ventricular unloading using mechanical circulatory support can reverse many of the cellular and anatomic changes that accompany ventricular remodeling. Ongoing research is evaluating the ability of left ventricular assist devices to promote myocardial recovery and remission from clinical heart failure.Myocardial injury induces significant changes in ventricular structure and function at both the cellular and anatomic level, leading to ventricular remodeling and subsequent heart failure. Unloading left ventricular pressure has been studied in both the short-term and long-term settings, as a means of preventing or reversing cardiac remodeling. In acute myocardial infarction, cardiac unloading is used to reduce oxygen demand and limit infarct size. Research has demonstrated the benefits of short-term unloading with mechanical circulatory support devices before reperfusion in the context of acute myocardial infarction with cardiogenic shock, and a confirmatory trial is ongoing. In chronic heart failure, ventricular unloading using mechanical circulatory support can reverse many of the cellular and anatomic changes that accompany ventricular remodeling. Ongoing research is evaluating the ability of left ventricular assist devices to promote myocardial recovery and remission from clinical heart failure. Myocardial injury induces significant changes in ventricular structure and function at both the cellular and anatomic level, leading to ventricular remodeling and subsequent heart failure. Unloading left ventricular pressure has been studied in both the short-term and long-term settings, as a means of preventing or reversing cardiac remodeling. In acute myocardial infarction, cardiac unloading is used to reduce oxygen demand and limit infarct size. Research has demonstrated the benefits of short-term unloading with mechanical circulatory support devices before reperfusion in the context of acute myocardial infarction with cardiogenic shock, and a confirmatory trial is ongoing. In chronic heart failure, ventricular unloading using mechanical circulatory support can reverse many of the cellular and anatomic changes that accompany ventricular remodeling. Ongoing research is evaluating the ability of left ventricular assist devices to promote myocardial recovery and remission from clinical heart failure. |
| Author | Annamalai, Shiva Uriel, Nir Burkhoff, Daniel Sayer, Gabriel Kapur, Navin K |
| Author_xml | – sequence: 1 givenname: Nir surname: Uriel fullname: Uriel, Nir email: nuriel@medicine.bsd.uchicago.edu organization: Section of Cardiology, University of Chicago, Chicago, Illinois. Electronic address: nuriel@medicine.bsd.uchicago.edu – sequence: 2 givenname: Gabriel surname: Sayer fullname: Sayer, Gabriel organization: Section of Cardiology, University of Chicago, Chicago, Illinois – sequence: 3 givenname: Shiva surname: Annamalai fullname: Annamalai, Shiva organization: The Cardiovascular Center, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts – sequence: 4 givenname: Navin K surname: Kapur fullname: Kapur, Navin K organization: The Cardiovascular Center, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts – sequence: 5 givenname: Daniel surname: Burkhoff fullname: Burkhoff, Daniel organization: Columbia University Medical Center, and Cardiovascular Research Foundation, New York, New York |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30056830$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Heart Failure - diagnosis Heart Failure - physiopathology Heart Failure - therapy Hemodynamics - physiology Humans Myocardial Infarction - diagnosis Myocardial Infarction - physiopathology Myocardial Infarction - therapy Ventricular Function, Left - physiology Ventricular Remodeling - physiology |
| Title | Mechanical Unloading in Heart Failure |
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