Non-calcifying Langerhans Cell Rich Variant of Calcifying Epithelial Odontogenic Tumor and Amyloid Rich Variant of Central Odontogenic Fibroma: A Unique Entity or a Spectrum?

Overlapping clinicopathological features of non-calcifying Langerhans cell rich variant of calcifying epithelial odontogenic tumor (NCLC-CEOT) and the amyloid rich variant of the central odontogenic fibroma (AR-COF) have been recognized recently. It is still under debate whether these two diseases a...

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Published in:	Frontiers in oral health Vol. 2; p. 767201
Main Authors:	Tseng, Chih-Huang, Lu, Pei-Hsuan, Wang, Yi-Ping, Chiang, Chun-Pin, Cheng, Yi-Shing Lisa, Chang, Julia Yu Fong
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media SA 25.10.2021 Frontiers Media S.A
Subjects:	amyloid rich variant central odontogenic fibroma Calcification calcifying epithelial odontogenic tumor Case reports central odontogenic fibroma Connective tissue Disease Females non-calcifying Langerhans cell rich variant CEOT odontogenic tumor Oral Health Tumors central odontogenic fibroma non-calcifying Langerhans cell rich variant CEOT calcifying epithelial odontogenic tumor amyloid rich variant central odontogenic fibroma odontogenic tumor
ISSN:	2673-4842, 2673-4842
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Abstract	Overlapping clinicopathological features of non-calcifying Langerhans cell rich variant of calcifying epithelial odontogenic tumor (NCLC-CEOT) and the amyloid rich variant of the central odontogenic fibroma (AR-COF) have been recognized recently. It is still under debate whether these two diseases are indeed one unique disease entity or belong to CEOT and COF, respectively. To clarify this issue, we have performed a literature review to compare the similarities and differences in clinicopathological features among NCLC-CEOT, AR-COF, classic CEOT, and classic COF. We aimed to investigate whether NCLC-CEOT and AR-COF might be the same and one distinctive disease entity, or a variant (or variants) of either CEOT or COF; or whether COF, NCLC-CEOT/AR-COF, and CEOT represented a histopathological spectrum of one disease. Our results indicate that NCLC-CEOT and AR-COF cases share many similar clinicopathological features. Thus, we suggest that they are the same disease entity. Due to nearly no reported recurrence of NCLC-CEOT/AR-COF cases, the conservative surgical treatment is appropriate. The NCLC-CEOT/AR-COF cases show some overlapping clinicopathological features with COF rather than the CEOT cases. However, differences in the clinicopathological features are still recognized among the NCLC-CEOT/AR-COF, COF, and CEOT cases. Future research, particularly molecular biological studies, may further elucidate their relationships and assist proper classification of the NCLC-CEOT/AR-COF cases.
AbstractList	Overlapping clinicopathological features of non-calcifying Langerhans cell rich variant of calcifying epithelial odontogenic tumor (NCLC-CEOT) and the amyloid rich variant of the central odontogenic fibroma (AR-COF) have been recognized recently. It is still under debate whether these two diseases are indeed one unique disease entity or belong to CEOT and COF, respectively. To clarify this issue, we have performed a literature review to compare the similarities and differences in clinicopathological features among NCLC-CEOT, AR-COF, classic CEOT, and classic COF. We aimed to investigate whether NCLC-CEOT and AR-COF might be the same and one distinctive disease entity, or a variant (or variants) of either CEOT or COF; or whether COF, NCLC-CEOT/AR-COF, and CEOT represented a histopathological spectrum of one disease. Our results indicate that NCLC-CEOT and AR-COF cases share many similar clinicopathological features. Thus, we suggest that they are the same disease entity. Due to nearly no reported recurrence of NCLC-CEOT/AR-COF cases, the conservative surgical treatment is appropriate. The NCLC-CEOT/AR-COF cases show some overlapping clinicopathological features with COF rather than the CEOT cases. However, differences in the clinicopathological features are still recognized among the NCLC-CEOT/AR-COF, COF, and CEOT cases. Future research, particularly molecular biological studies, may further elucidate their relationships and assist proper classification of the NCLC-CEOT/AR-COF cases. Overlapping clinicopathological features of non-calcifying Langerhans cell rich variant of calcifying epithelial odontogenic tumor (NCLC-CEOT) and the amyloid rich variant of the central odontogenic fibroma (AR-COF) have been recognized recently. It is still under debate whether these two diseases are indeed one unique disease entity or belong to CEOT and COF, respectively. To clarify this issue, we have performed a literature review to compare the similarities and differences in clinicopathological features among NCLC-CEOT, AR-COF, classic CEOT, and classic COF. We aimed to investigate whether NCLC-CEOT and AR-COF might be the same and one distinctive disease entity, or a variant (or variants) of either CEOT or COF; or whether COF, NCLC-CEOT/AR-COF, and CEOT represented a histopathological spectrum of one disease. Our results indicate that NCLC-CEOT and AR-COF cases share many similar clinicopathological features. Thus, we suggest that they are the same disease entity. Due to nearly no reported recurrence of NCLC-CEOT/AR-COF cases, the conservative surgical treatment is appropriate. The NCLC-CEOT/AR-COF cases show some overlapping clinicopathological features with COF rather than the CEOT cases. However, differences in the clinicopathological features are still recognized among the NCLC-CEOT/AR-COF, COF, and CEOT cases. Future research, particularly molecular biological studies, may further elucidate their relationships and assist proper classification of the NCLC-CEOT/AR-COF cases.Overlapping clinicopathological features of non-calcifying Langerhans cell rich variant of calcifying epithelial odontogenic tumor (NCLC-CEOT) and the amyloid rich variant of the central odontogenic fibroma (AR-COF) have been recognized recently. It is still under debate whether these two diseases are indeed one unique disease entity or belong to CEOT and COF, respectively. To clarify this issue, we have performed a literature review to compare the similarities and differences in clinicopathological features among NCLC-CEOT, AR-COF, classic CEOT, and classic COF. We aimed to investigate whether NCLC-CEOT and AR-COF might be the same and one distinctive disease entity, or a variant (or variants) of either CEOT or COF; or whether COF, NCLC-CEOT/AR-COF, and CEOT represented a histopathological spectrum of one disease. Our results indicate that NCLC-CEOT and AR-COF cases share many similar clinicopathological features. Thus, we suggest that they are the same disease entity. Due to nearly no reported recurrence of NCLC-CEOT/AR-COF cases, the conservative surgical treatment is appropriate. The NCLC-CEOT/AR-COF cases show some overlapping clinicopathological features with COF rather than the CEOT cases. However, differences in the clinicopathological features are still recognized among the NCLC-CEOT/AR-COF, COF, and CEOT cases. Future research, particularly molecular biological studies, may further elucidate their relationships and assist proper classification of the NCLC-CEOT/AR-COF cases.
Author	Tseng, Chih-Huang Lu, Pei-Hsuan Wang, Yi-Ping Chiang, Chun-Pin Cheng, Yi-Shing Lisa Chang, Julia Yu Fong
AuthorAffiliation	1 Division of Oral Pathology and Maxillofacial Radiology, Kaohsiung Medical University Hospital , Kaohsiung , Taiwan 4 Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University , Taipei , Taiwan 3 Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University , Taipei , Taiwan 7 Department of Diagnostic Sciences, Texas A&M University College of Dentistry , Dallas, TX , United States 5 Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University , Taipei , Taiwan 2 Oral and Maxillofacial Imaging Center, College of Dental Medicine, Kaohsiung Medical University , Kaohsiung , Taiwan 6 Department of Dentistry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation , Hualien , Taiwan
AuthorAffiliation_xml	– name: 2 Oral and Maxillofacial Imaging Center, College of Dental Medicine, Kaohsiung Medical University , Kaohsiung , Taiwan – name: 7 Department of Diagnostic Sciences, Texas A&M University College of Dentistry , Dallas, TX , United States – name: 6 Department of Dentistry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation , Hualien , Taiwan – name: 1 Division of Oral Pathology and Maxillofacial Radiology, Kaohsiung Medical University Hospital , Kaohsiung , Taiwan – name: 3 Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University , Taipei , Taiwan – name: 5 Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University , Taipei , Taiwan – name: 4 Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University , Taipei , Taiwan
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Keywords	central odontogenic fibroma non-calcifying Langerhans cell rich variant CEOT calcifying epithelial odontogenic tumor amyloid rich variant central odontogenic fibroma odontogenic tumor
Language	English
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 This article was submitted to Oral Cancers, a section of the journal Frontiers in Oral Health These authors have contributed equally to this work Reviewed by: Mário José Romañach, Federal University of Rio de Janeiro, Brazil; Celeste Sanchez-Romero, University of the Republic, Uruguay Edited by: Ricardo Santiago Gomez, Federal University of Minas Gerais, Brazil
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Snippet	Overlapping clinicopathological features of non-calcifying Langerhans cell rich variant of calcifying epithelial odontogenic tumor (NCLC-CEOT) and the amyloid...
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SubjectTerms	amyloid rich variant central odontogenic fibroma Calcification calcifying epithelial odontogenic tumor Case reports central odontogenic fibroma Connective tissue Disease Females non-calcifying Langerhans cell rich variant CEOT odontogenic tumor Oral Health Tumors
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Title	Non-calcifying Langerhans Cell Rich Variant of Calcifying Epithelial Odontogenic Tumor and Amyloid Rich Variant of Central Odontogenic Fibroma: A Unique Entity or a Spectrum?
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