Tight regulation of memory CD8(+) T cells limits their effectiveness during sustained high viral load

To design successful vaccines for chronic diseases, an understanding of memory CD8(+) T cell responses to persistent antigen restimulation is critical. However, most studies comparing memory and naive cell responses have been performed only in rapidly cleared acute infections. Herein, by comparing t...

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Bibliographic Details
Published in:	Immunity (Cambridge, Mass.) Vol. 35; no. 2; p. 285
Main Authors:	West, Erin E, Youngblood, Ben, Tan, Wendy G, Jin, Hyun-Tak, Araki, Koichi, Alexe, Gabriela, Konieczny, Bogumila T, Calpe, Silvia, Freeman, Gordon J, Terhorst, Cox, Haining, W Nicholas, Ahmed, Rafi
Format:	Journal Article
Language:	English
Published:	United States 26.08.2011
Subjects:	Acute Disease Adoptive Transfer Animals Antigens, CD - immunology Antigens, CD - metabolism Arenaviridae Infections - immunology Arenaviridae Infections - virology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - pathology CD8-Positive T-Lymphocytes - virology Cell Proliferation Cells, Cultured Chronic Disease Cytokines - immunology Cytokines - metabolism Immunologic Memory Lymphocytic choriomeningitis virus - pathogenicity Lymphocytic choriomeningitis virus - physiology Mice Mice, Inbred C57BL Mice, Transgenic Paracrine Communication Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Immunologic - immunology Receptors, Immunologic - metabolism Signaling Lymphocytic Activation Molecule Family T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - pathology T-Lymphocyte Subsets - virology Viral Load Viral Vaccines
ISSN:	1097-4180, 1097-4180
Online Access:	Get more information
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