Delayed Diagnosis of Hidradenitis Suppurativa and Its Effect on Patients and Healthcare System
Background: Hidradenitis suppurativa (HS) is a neglected chronic inflammatory disease with long delay in diagnosis. Besides pain, purulent discharge, and destruction of skin architecture, HS patients experience metabolic, musculoskeletal, and psychological disorders. Objectives: To determine the del...
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| Veröffentlicht in: | Dermatology (Basel) Jg. 236; H. 5; S. 421 - 430 |
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2020
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| Abstract | Background: Hidradenitis suppurativa (HS) is a neglected chronic inflammatory disease with long delay in diagnosis. Besides pain, purulent discharge, and destruction of skin architecture, HS patients experience metabolic, musculoskeletal, and psychological disorders. Objectives: To determine the delay in HS diagnosis and its consequences for patients and the healthcare system. Methods: This was a prospective, multicenter, epidemiologic, non-interventional cross-sectional trial carried out in Germany and based on self-reported questionnaires and medical examinations performed by dermatologists. In total, data of 394 adult HS patients were evaluated. Results: The average duration from manifestation of first symptoms until HS diagnosis was 10.0 ± 9.6 (mean ± SD) years. During this time, HS patients consulted on average more than 3 different physicians – most frequently general practitioners, dermatologists, surgeons, gynecologists – and faced more than 3 misdiagnoses. Diagnosis delay was longer in younger and non-smoking patients. In most cases, HS was correctly diagnosed by dermatologists. The longer the delay of diagnosis, the greater the disease severity at diagnosis. Delayed HS diagnosis was also associated with an increased number of surgically treated sites, concomitant diseases, and days of work missed. Conclusion: This study demonstrates an enormous delay in the diagnosis of HS, which results in more severe disease. It also shows for the first time that a delay in diagnosis of a chronic inflammatory disease leads to a higher number of concomitant systemic disorders. In addition to the impaired health status, delayed diagnosis of HS was associated with impairment of the professional life of affected people. |
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| AbstractList | Hidradenitis suppurativa (HS) is a neglected chronic inflammatory disease with long delay in diagnosis. Besides pain, purulent discharge, and destruction of skin architecture, HS patients experience metabolic, musculoskeletal, and psychological disorders.
To determine the delay in HS diagnosis and its consequences for patients and the healthcare system.
This was a prospective, multicenter, epidemiologic, non-interventional cross-sectional trial carried out in Germany and based on self-reported questionnaires and medical examinations performed by dermatologists. In total, data of 394 adult HS patients were evaluated.
The average duration from manifestation of first symptoms until HS diagnosis was 10.0 ± 9.6 (mean ± SD) years. During this time, HS patients consulted on average more than 3 different physicians - most frequently general practitioners, dermatologists, surgeons, gynecologists - and faced more than 3 misdiagnoses. Diagnosis delay was longer in younger and non-smoking patients. In most cases, HS was correctly diagnosed by dermatologists. The longer the delay of diagnosis, the greater the disease severity at diagnosis. Delayed HS diagnosis was also associated with an increased number of surgically treated sites, concomitant diseases, and days of work missed.
This study demonstrates an enormous delay in the diagnosis of HS, which results in more severe disease. It also shows for the first time that a delay in diagnosis of a chronic inflammatory disease leads to a higher number of concomitant systemic disorders. In addition to the impaired health status, delayed diagnosis of HS was associated with impairment of the professional life of affected people. Background: Hidradenitis suppurativa (HS) is a neglected chronic inflammatory disease with long delay in diagnosis. Besides pain, purulent discharge, and destruction of skin architecture, HS patients experience metabolic, musculoskeletal, and psychological disorders. Objectives: To determine the delay in HS diagnosis and its consequences for patients and the healthcare system. Methods: This was a prospective, multicenter, epidemiologic, non-interventional cross-sectional trial carried out in Germany and based on self-reported questionnaires and medical examinations performed by dermatologists. In total, data of 394 adult HS patients were evaluated. Results: The average duration from manifestation of first symptoms until HS diagnosis was 10.0 ± 9.6 (mean ± SD) years. During this time, HS patients consulted on average more than 3 different physicians – most frequently general practitioners, dermatologists, surgeons, gynecologists – and faced more than 3 misdiagnoses. Diagnosis delay was longer in younger and non-smoking patients. In most cases, HS was correctly diagnosed by dermatologists. The longer the delay of diagnosis, the greater the disease severity at diagnosis. Delayed HS diagnosis was also associated with an increased number of surgically treated sites, concomitant diseases, and days of work missed. Conclusion: This study demonstrates an enormous delay in the diagnosis of HS, which results in more severe disease. It also shows for the first time that a delay in diagnosis of a chronic inflammatory disease leads to a higher number of concomitant systemic disorders. In addition to the impaired health status, delayed diagnosis of HS was associated with impairment of the professional life of affected people. Hidradenitis suppurativa (HS) is a neglected chronic inflammatory disease with long delay in diagnosis. Besides pain, purulent discharge, and destruction of skin architecture, HS patients experience metabolic, musculoskeletal, and psychological disorders.BACKGROUNDHidradenitis suppurativa (HS) is a neglected chronic inflammatory disease with long delay in diagnosis. Besides pain, purulent discharge, and destruction of skin architecture, HS patients experience metabolic, musculoskeletal, and psychological disorders.To determine the delay in HS diagnosis and its consequences for patients and the healthcare system.OBJECTIVESTo determine the delay in HS diagnosis and its consequences for patients and the healthcare system.This was a prospective, multicenter, epidemiologic, non-interventional cross-sectional trial carried out in Germany and based on self-reported questionnaires and medical examinations performed by dermatologists. In total, data of 394 adult HS patients were evaluated.METHODSThis was a prospective, multicenter, epidemiologic, non-interventional cross-sectional trial carried out in Germany and based on self-reported questionnaires and medical examinations performed by dermatologists. In total, data of 394 adult HS patients were evaluated.The average duration from manifestation of first symptoms until HS diagnosis was 10.0 ± 9.6 (mean ± SD) years. During this time, HS patients consulted on average more than 3 different physicians - most frequently general practitioners, dermatologists, surgeons, gynecologists - and faced more than 3 misdiagnoses. Diagnosis delay was longer in younger and non-smoking patients. In most cases, HS was correctly diagnosed by dermatologists. The longer the delay of diagnosis, the greater the disease severity at diagnosis. Delayed HS diagnosis was also associated with an increased number of surgically treated sites, concomitant diseases, and days of work missed.RESULTSThe average duration from manifestation of first symptoms until HS diagnosis was 10.0 ± 9.6 (mean ± SD) years. During this time, HS patients consulted on average more than 3 different physicians - most frequently general practitioners, dermatologists, surgeons, gynecologists - and faced more than 3 misdiagnoses. Diagnosis delay was longer in younger and non-smoking patients. In most cases, HS was correctly diagnosed by dermatologists. The longer the delay of diagnosis, the greater the disease severity at diagnosis. Delayed HS diagnosis was also associated with an increased number of surgically treated sites, concomitant diseases, and days of work missed.This study demonstrates an enormous delay in the diagnosis of HS, which results in more severe disease. It also shows for the first time that a delay in diagnosis of a chronic inflammatory disease leads to a higher number of concomitant systemic disorders. In addition to the impaired health status, delayed diagnosis of HS was associated with impairment of the professional life of affected people.CONCLUSIONThis study demonstrates an enormous delay in the diagnosis of HS, which results in more severe disease. It also shows for the first time that a delay in diagnosis of a chronic inflammatory disease leads to a higher number of concomitant systemic disorders. In addition to the impaired health status, delayed diagnosis of HS was associated with impairment of the professional life of affected people. |
| Author | Barbus, Sebastian Kalus, Stefanie Gomis-Kleindienst, Susana Kokolakis, Georgios Sabat, Robert Wolk, Kerstin Schneider-Burrus, Sylke |
| Author_xml | – sequence: 1 givenname: Georgios surname: Kokolakis fullname: Kokolakis, Georgios – sequence: 2 givenname: Kerstin surname: Wolk fullname: Wolk, Kerstin – sequence: 3 givenname: Sylke surname: Schneider-Burrus fullname: Schneider-Burrus, Sylke – sequence: 4 givenname: Stefanie surname: Kalus fullname: Kalus, Stefanie – sequence: 5 givenname: Sebastian surname: Barbus fullname: Barbus, Sebastian – sequence: 6 givenname: Susana surname: Gomis-Kleindienst fullname: Gomis-Kleindienst, Susana – sequence: 7 givenname: Robert surname: Sabat fullname: Sabat, Robert email: *Robert Sabat, Interdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology, Charité – Universitätsmedizin Berlin, Charitéplatz 1, DE–10117 Berlin (Germany), robert.sabat@charite.de |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32610312$$D View this record in MEDLINE/PubMed |
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| Keywords | Healthcare system Diagnosis Acne inversa Hidradenitis suppurativa Comorbidity |
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| References | Theut Riis P, Thorlacius L, Knudsen List E, Jemec GB. A pilot study of unemployment in patients with hidradenitis suppurativa in Denmark. Br J Dermatol. 2017Apr;176(4):1083–5. 10.1111/bjd.14922274806110007-0963 Miller IM, Ellervik C, Vinding GR, Zarchi K, Ibler KS, Knudsen KM, et al.. Association of metabolic syndrome and hidradenitis suppurativa. JAMA Dermatol. 2014Dec;150(12):1273–80. 10.1001/jamadermatol.2014.1165252299962168-6068 Sabat R, Jemec GB, Matusiak Ł, Kimball AB, Prens E, Wolk K. Hidradenitis suppurativa. Nat Rev Dis Primers. 2020Mar;6(1):18. 10.1038/s41572-020-0149-1321656202056-676X Schneider-Burrus S, Jost A, Peters EM, Witte-Haendel E, Sterry W, Sabat R. Association of Hidradenitis Suppurativa With Body Image. JAMA Dermatol. 2018Apr;154(4):447–51. 10.1001/jamadermatol.2017.6058294665462168-6068 Richette P, Molto A, Viguier M, Dawidowicz K, Hayem G, Nassif A, et al.. Hidradenitis suppurativa associated with spondyloarthritis— results from a multicenter national prospective study. J Rheumatol. 2014Mar;41(3):490–4. 10.3899/jrheum.130977244291660315-162X Boehncke WH. Systemic Inflammation and Cardiovascular Comorbidity in Psoriasis Patients: causes and Consequences. Front Immunol. 2018Apr;9:579. 10.3389/fimmu.2018.00579296750201664-3224 Kromann CB, Deckers IE, Esmann S, Boer J, Prens EP, Jemec GB. Risk factors, clinical course and long-term prognosis in hidradenitis suppurativa: a cross-sectional study. Br J Dermatol. 2014Oct;171(4):819–24. 10.1111/bjd.13090248046040007-0963 Ritz JP, Runkel N, Haier J, Buhr HJ. Extent of surgery and recurrence rate of hidradenitis suppurativa. Int J Colorectal Dis. 1998;13(4):164–8. 10.1007/s00384005015998105200179-1958 Garg A, Papagermanos V, Midura M, Strunk A. Incidence of hidradenitis suppurativa among tobacco smokers: a population-based retrospective analysis in the U.S.A. Br J Dermatol. 2018Mar;178(3):709–14. 10.1111/bjd.15939289602350007-0963 Taams LS, Steel KJ, Srenathan U, Burns LA, Kirkham BW. IL-17 in the immunopathogenesis of spondyloarthritis. Nat Rev Rheumatol. 2018Aug;14(8):453–66. 10.1038/s41584-018-0044-2300066011759-4790 Saunte DM, Boer J, Stratigos A, Szepietowski JC, Hamzavi I, Kim KH, et al.. Diagnostic delay in hidradenitis suppurativa is a global problem. Br J Dermatol. 2015Dec;173(6):1546–9. 10.1111/bjd.14038261981910007-0963 Ingram JR, Jenkins-Jones S, Knipe DW, Morgan CL, Cannings-John R, Piguet V. Population-based Clinical Practice Research Datalink study using algorithm modelling to identify the true burden of hidradenitis suppurativa. Br J Dermatol. 2018Apr;178(4):917–24. 10.1111/bjd.16101290943460007-0963 Karagiannidis I, Nikolakis G, Sabat R, Zouboulis CC. Hidradenitis suppurativa/Acne inversa: an endocrine skin disorder. Rev Endocr Metab Disord. 2016Sep;17(3):335–41. 10.1007/s11154-016-9366-z272945931389-9155 Wolk K, Wenzel J, Tsaousi A, Witte-Händel E, Babel N, Zelenak C, et al.. Lipocalin-2 is expressed by activated granulocytes and keratinocytes in affected skin and reflects disease activity in acne inversa/hidradenitis suppurativa. Br J Dermatol. 2017Nov;177(5):1385–93. 10.1111/bjd.15424282567180007-0963 Khalsa A, Liu G, Kirby JS. Increased utilization of emergency department and inpatient care by patients with hidradenitis suppurativa. J Am Acad Dermatol. 2015Oct;73(4):609–14. 10.1016/j.jaad.2015.06.053261902410190-9622 Kurek A, Peters EM, Chanwangpong A, Sabat R, Sterry W, Schneider-Burrus S. Profound disturbances of sexual health in patients with acne inversa. J Am Acad Dermatol. 2012;67(3):422-8, 8 e1. Matusiak L, Bieniek A, Szepietowski JC. Hidradenitis suppurativa markedly decreases quality of life and professional activity. J Am Acad Dermatol. 2010;62(4):706-8, 8 e1. Hessam S, Sand M, Gambichler T, Skrygan M, Rüddel I, Bechara FG. Interleukin-36 in hidradenitis suppurativa: evidence for a distinctive proinflammatory role and a key factor in the development of an inflammatory loop. Br J Dermatol. 2018Mar;178(3):761–7. 10.1111/bjd.16019289756260007-0963 Schneider-Burrus S, Witte-Haendel E, Christou D, Rigoni B, Sabat R, Diederichs G. High Prevalence of Back Pain and Axial Spondyloarthropathy in Patients with Hidradenitis Suppurativa. Dermatology. 2016;232(5):606–12. 10.1159/000448838276494171018-8665 Tsaousi A, Witte E, Witte K, Röwert-Huber HJ, Volk HD, Sterry W, et al.. MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations. Mediators Inflamm. 2016;2016:4097574. 10.1155/2016/4097574278432000962-9351 van der Zee HH, de Ruiter L, van den Broecke DG, Dik WA, Laman JD, Prens EP. Elevated levels of tumour necrosis factor (TNF)-α, interleukin (IL)-1β and IL-10 in hidradenitis suppurativa skin: a rationale for targeting TNF-α and IL-1β. Br J Dermatol. 2011Jun;164(6):1292–8. 10.1111/j.1365-2133.2011.10254.x213324640007-0963 Lima AL, Karl I, Giner T, Poppe H, Schmidt M, Presser D, et al.. Keratinocytes and neutrophils are important sources of proinflammatory molecules in hidradenitis suppurativa. Br J Dermatol. 2016Mar;174(3):514–21. 10.1111/bjd.14214264365220007-0963 Elnabawi YA, Dey AK, Goyal A, Groenendyk JW, Chung JH, Belur AD, et al.. Coronary artery plaque characteristics and treatment with biologic therapy in severe psoriasis: results from a prospective observational study. Cardiovasc Res. 2019Mar;115(4):721–8. 10.1093/cvr/cvz009307219330008-6363 Wolkenstein P, Loundou A, Barrau K, Auquier P, Revuz J; Quality of Life Group of the French Society of Dermatology. Quality of life impairment in hidradenitis suppurativa: a study of 61 cases. J Am Acad Dermatol. 2007Apr;56(4):621–3. 10.1016/j.jaad.2006.08.061170973660190-9622 Sabat R, Chanwangpong A, Schneider-Burrus S, Metternich D, Kokolakis G, Kurek A, et al.. Increased prevalence of metabolic syndrome in patients with acne inversa. PLoS One. 2012;7(2):e31810. 10.1371/journal.pone.0031810223596341932-6203 Deckers IE, Janse IC, van der Zee HH, Nijsten T, Boer J, Horvath B, et al. Hidradenitis suppurativa (HS) is associated with low socioeconomic status (SES): A cross-sectional reference study. J Am Acad Dermatol. 2016;75(4):755-9 e1. Piaserico S, Osto E, Famoso G, Zanetti I, Gregori D, Poretto A, et al.. Treatment with tumor necrosis factor inhibitors restores coronary microvascular function in young patients with severe psoriasis. Atherosclerosis. 2016Aug;251:25–30. 10.1016/j.atherosclerosis.2016.05.036272363530021-9150 Loget J, Saint-Martin C, Guillem P, Kanagaratnam L, Becherel PA, Nassif A, et al.; sous l’égide de « ResoVerneil ». [Misdiagnosis of hidradenitis suppurativa continues to be a major issue. The R-ENS Verneuil study]. Ann Dermatol Venereol. 2018May;145(5):331–8. 10.1016/j.annder.2018.01.043297049580151-9638 Egeberg A, Gislason GH, Hansen PR. Risk of Major Adverse Cardiovascular Events and All-Cause Mortality in Patients With Hidradenitis Suppurativa. JAMA Dermatol. 2016Apr;152(4):429–34. 10.1001/jamadermatol.2015.6264268857282168-6068 Wolk K, Warszawska K, Hoeflich C, Witte E, Schneider-Burrus S, Witte K, et al.. Deficiency of IL-22 contributes to a chronic inflammatory disease: pathogenetic mechanisms in acne inversa. J Immunol. 2011Jan;186(2):1228–39. 10.4049/jimmunol.0903907211480410022-1767 Witte-Händel E, Wolk K, Tsaousi A, Irmer ML, Mößner R, Shomroni O, et al.. The IL-1 Pathway Is Hyperactive in Hidradenitis Suppurativa and Contributes to Skin Infiltration and Destruction. J Invest Dermatol. 2019Jun;139(6):1294–305. 10.1016/j.jid.2018.11.018305288240022-202X Horváth B, Janse IC, Sibbald GR. Pain management in patients with hidradenitis suppurativa. J Am Acad Dermatol. 2015Nov;73(5Suppl 1):S47–51. 10.1016/j.jaad.2015.07.046264706160190-9622 Sabat R, Wolk K, Loyal L, Döcke WD, Ghoreschi K. T cell pathology in skin inflammation. Semin Immunopathol. 2019May;41(3):359–77. 10.1007/s00281-019-00742-7310284341863-2297 |
| References_xml | – reference: Schneider-Burrus S, Jost A, Peters EM, Witte-Haendel E, Sterry W, Sabat R. Association of Hidradenitis Suppurativa With Body Image. JAMA Dermatol. 2018Apr;154(4):447–51. 10.1001/jamadermatol.2017.6058294665462168-6068 – reference: Ritz JP, Runkel N, Haier J, Buhr HJ. Extent of surgery and recurrence rate of hidradenitis suppurativa. Int J Colorectal Dis. 1998;13(4):164–8. 10.1007/s00384005015998105200179-1958 – reference: Wolk K, Wenzel J, Tsaousi A, Witte-Händel E, Babel N, Zelenak C, et al.. Lipocalin-2 is expressed by activated granulocytes and keratinocytes in affected skin and reflects disease activity in acne inversa/hidradenitis suppurativa. Br J Dermatol. 2017Nov;177(5):1385–93. 10.1111/bjd.15424282567180007-0963 – reference: Kromann CB, Deckers IE, Esmann S, Boer J, Prens EP, Jemec GB. Risk factors, clinical course and long-term prognosis in hidradenitis suppurativa: a cross-sectional study. Br J Dermatol. 2014Oct;171(4):819–24. 10.1111/bjd.13090248046040007-0963 – reference: Hessam S, Sand M, Gambichler T, Skrygan M, Rüddel I, Bechara FG. Interleukin-36 in hidradenitis suppurativa: evidence for a distinctive proinflammatory role and a key factor in the development of an inflammatory loop. Br J Dermatol. 2018Mar;178(3):761–7. 10.1111/bjd.16019289756260007-0963 – reference: Kurek A, Peters EM, Chanwangpong A, Sabat R, Sterry W, Schneider-Burrus S. Profound disturbances of sexual health in patients with acne inversa. J Am Acad Dermatol. 2012;67(3):422-8, 8 e1. – reference: Karagiannidis I, Nikolakis G, Sabat R, Zouboulis CC. Hidradenitis suppurativa/Acne inversa: an endocrine skin disorder. Rev Endocr Metab Disord. 2016Sep;17(3):335–41. 10.1007/s11154-016-9366-z272945931389-9155 – reference: Ingram JR, Jenkins-Jones S, Knipe DW, Morgan CL, Cannings-John R, Piguet V. Population-based Clinical Practice Research Datalink study using algorithm modelling to identify the true burden of hidradenitis suppurativa. Br J Dermatol. 2018Apr;178(4):917–24. 10.1111/bjd.16101290943460007-0963 – reference: Tsaousi A, Witte E, Witte K, Röwert-Huber HJ, Volk HD, Sterry W, et al.. MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations. Mediators Inflamm. 2016;2016:4097574. 10.1155/2016/4097574278432000962-9351 – reference: Miller IM, Ellervik C, Vinding GR, Zarchi K, Ibler KS, Knudsen KM, et al.. Association of metabolic syndrome and hidradenitis suppurativa. JAMA Dermatol. 2014Dec;150(12):1273–80. 10.1001/jamadermatol.2014.1165252299962168-6068 – reference: Boehncke WH. Systemic Inflammation and Cardiovascular Comorbidity in Psoriasis Patients: causes and Consequences. Front Immunol. 2018Apr;9:579. 10.3389/fimmu.2018.00579296750201664-3224 – reference: Elnabawi YA, Dey AK, Goyal A, Groenendyk JW, Chung JH, Belur AD, et al.. Coronary artery plaque characteristics and treatment with biologic therapy in severe psoriasis: results from a prospective observational study. Cardiovasc Res. 2019Mar;115(4):721–8. 10.1093/cvr/cvz009307219330008-6363 – reference: Wolkenstein P, Loundou A, Barrau K, Auquier P, Revuz J; Quality of Life Group of the French Society of Dermatology. Quality of life impairment in hidradenitis suppurativa: a study of 61 cases. J Am Acad Dermatol. 2007Apr;56(4):621–3. 10.1016/j.jaad.2006.08.061170973660190-9622 – reference: Schneider-Burrus S, Witte-Haendel E, Christou D, Rigoni B, Sabat R, Diederichs G. High Prevalence of Back Pain and Axial Spondyloarthropathy in Patients with Hidradenitis Suppurativa. Dermatology. 2016;232(5):606–12. 10.1159/000448838276494171018-8665 – reference: Horváth B, Janse IC, Sibbald GR. Pain management in patients with hidradenitis suppurativa. J Am Acad Dermatol. 2015Nov;73(5Suppl 1):S47–51. 10.1016/j.jaad.2015.07.046264706160190-9622 – reference: Wolk K, Warszawska K, Hoeflich C, Witte E, Schneider-Burrus S, Witte K, et al.. Deficiency of IL-22 contributes to a chronic inflammatory disease: pathogenetic mechanisms in acne inversa. J Immunol. 2011Jan;186(2):1228–39. 10.4049/jimmunol.0903907211480410022-1767 – reference: Loget J, Saint-Martin C, Guillem P, Kanagaratnam L, Becherel PA, Nassif A, et al.; sous l’égide de « ResoVerneil ». [Misdiagnosis of hidradenitis suppurativa continues to be a major issue. The R-ENS Verneuil study]. Ann Dermatol Venereol. 2018May;145(5):331–8. 10.1016/j.annder.2018.01.043297049580151-9638 – reference: van der Zee HH, de Ruiter L, van den Broecke DG, Dik WA, Laman JD, Prens EP. Elevated levels of tumour necrosis factor (TNF)-α, interleukin (IL)-1β and IL-10 in hidradenitis suppurativa skin: a rationale for targeting TNF-α and IL-1β. Br J Dermatol. 2011Jun;164(6):1292–8. 10.1111/j.1365-2133.2011.10254.x213324640007-0963 – reference: Lima AL, Karl I, Giner T, Poppe H, Schmidt M, Presser D, et al.. Keratinocytes and neutrophils are important sources of proinflammatory molecules in hidradenitis suppurativa. Br J Dermatol. 2016Mar;174(3):514–21. 10.1111/bjd.14214264365220007-0963 – reference: Piaserico S, Osto E, Famoso G, Zanetti I, Gregori D, Poretto A, et al.. Treatment with tumor necrosis factor inhibitors restores coronary microvascular function in young patients with severe psoriasis. Atherosclerosis. 2016Aug;251:25–30. 10.1016/j.atherosclerosis.2016.05.036272363530021-9150 – reference: Deckers IE, Janse IC, van der Zee HH, Nijsten T, Boer J, Horvath B, et al. Hidradenitis suppurativa (HS) is associated with low socioeconomic status (SES): A cross-sectional reference study. J Am Acad Dermatol. 2016;75(4):755-9 e1. – reference: Sabat R, Wolk K, Loyal L, Döcke WD, Ghoreschi K. T cell pathology in skin inflammation. Semin Immunopathol. 2019May;41(3):359–77. 10.1007/s00281-019-00742-7310284341863-2297 – reference: Theut Riis P, Thorlacius L, Knudsen List E, Jemec GB. A pilot study of unemployment in patients with hidradenitis suppurativa in Denmark. Br J Dermatol. 2017Apr;176(4):1083–5. 10.1111/bjd.14922274806110007-0963 – reference: Khalsa A, Liu G, Kirby JS. Increased utilization of emergency department and inpatient care by patients with hidradenitis suppurativa. J Am Acad Dermatol. 2015Oct;73(4):609–14. 10.1016/j.jaad.2015.06.053261902410190-9622 – reference: Garg A, Papagermanos V, Midura M, Strunk A. Incidence of hidradenitis suppurativa among tobacco smokers: a population-based retrospective analysis in the U.S.A. Br J Dermatol. 2018Mar;178(3):709–14. 10.1111/bjd.15939289602350007-0963 – reference: Matusiak L, Bieniek A, Szepietowski JC. Hidradenitis suppurativa markedly decreases quality of life and professional activity. J Am Acad Dermatol. 2010;62(4):706-8, 8 e1. – reference: Witte-Händel E, Wolk K, Tsaousi A, Irmer ML, Mößner R, Shomroni O, et al.. The IL-1 Pathway Is Hyperactive in Hidradenitis Suppurativa and Contributes to Skin Infiltration and Destruction. J Invest Dermatol. 2019Jun;139(6):1294–305. 10.1016/j.jid.2018.11.018305288240022-202X – reference: Egeberg A, Gislason GH, Hansen PR. Risk of Major Adverse Cardiovascular Events and All-Cause Mortality in Patients With Hidradenitis Suppurativa. JAMA Dermatol. 2016Apr;152(4):429–34. 10.1001/jamadermatol.2015.6264268857282168-6068 – reference: Sabat R, Chanwangpong A, Schneider-Burrus S, Metternich D, Kokolakis G, Kurek A, et al.. Increased prevalence of metabolic syndrome in patients with acne inversa. PLoS One. 2012;7(2):e31810. 10.1371/journal.pone.0031810223596341932-6203 – reference: Saunte DM, Boer J, Stratigos A, Szepietowski JC, Hamzavi I, Kim KH, et al.. Diagnostic delay in hidradenitis suppurativa is a global problem. Br J Dermatol. 2015Dec;173(6):1546–9. 10.1111/bjd.14038261981910007-0963 – reference: Richette P, Molto A, Viguier M, Dawidowicz K, Hayem G, Nassif A, et al.. Hidradenitis suppurativa associated with spondyloarthritis— results from a multicenter national prospective study. J Rheumatol. 2014Mar;41(3):490–4. 10.3899/jrheum.130977244291660315-162X – reference: Sabat R, Jemec GB, Matusiak Ł, Kimball AB, Prens E, Wolk K. Hidradenitis suppurativa. Nat Rev Dis Primers. 2020Mar;6(1):18. 10.1038/s41572-020-0149-1321656202056-676X – reference: Taams LS, Steel KJ, Srenathan U, Burns LA, Kirkham BW. IL-17 in the immunopathogenesis of spondyloarthritis. Nat Rev Rheumatol. 2018Aug;14(8):453–66. 10.1038/s41584-018-0044-2300066011759-4790 |
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| Snippet | Background: Hidradenitis suppurativa (HS) is a neglected chronic inflammatory disease with long delay in diagnosis. Besides pain, purulent discharge, and... Hidradenitis suppurativa (HS) is a neglected chronic inflammatory disease with long delay in diagnosis. Besides pain, purulent discharge, and destruction of... |
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| Title | Delayed Diagnosis of Hidradenitis Suppurativa and Its Effect on Patients and Healthcare System |
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