Proteostasis During Cerebral Ischemia

Cerebral ischemia is a complex pathology involving a cascade of cellular mechanisms, which deregulate proteostasis and lead to neuronal death. Proteostasis refers to the equilibrium between protein synthesis, folding, transport, and protein degradation. Within the brain proteostasis plays key roles...

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Veröffentlicht in:Frontiers in neuroscience Jg. 13; S. 637
Hauptverfasser: Thiebaut, Audrey M., Hedou, Elodie, Marciniak, Stefan J., Vivien, Denis, Roussel, Benoit D.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland Frontiers Research Foundation 19.06.2019
Frontiers Media S.A
Schlagworte:
Apoptosis
Autophagy
Brain research
Cell death
Cell survival
Diabetes
Endoplasmic reticulum
ER stress
Homeostasis
Hypoxia
Ischemia
Kinases
mTOR
Neurological disorders
Neuroscience
Phagocytosis
Protein biosynthesis
Protein folding
Protein synthesis
Protein transport
Proteins
proteostasis
Stroke
United Kingdom > UK
France
ER stress
mTOR
autophagy
proteostasis
stroke
ISSN:1662-453X, 1662-4548, 1662-453X
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Zusammenfassung:Cerebral ischemia is a complex pathology involving a cascade of cellular mechanisms, which deregulate proteostasis and lead to neuronal death. Proteostasis refers to the equilibrium between protein synthesis, folding, transport, and protein degradation. Within the brain proteostasis plays key roles in learning and memory by controlling protein synthesis and degradation. Two important pathways are implicated in the regulation of proteostasis: the unfolded protein response (UPR) and macroautophagy (called hereafter autophagy). Both are necessary for cell survival, however, their over-activation in duration or intensity can lead to cell death. Moreover, UPR and autophagy can activate and potentiate each other to worsen the issue of cerebral ischemia. A better understanding of autophagy and ER stress will allow the development of therapeutic strategies for stroke, both at the acute phase and during recovery. This review summarizes the latest therapeutic advances implicating ER stress or autophagy in cerebral ischemia. We argue that the processes governing proteostasis should be considered together in stroke, rather than focusing either on ER stress or autophagy in isolation.
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Edited by: Mathias Gelderblom, University Medical Center Hamburg-Eppendorf, Germany
This article was submitted to Neurodegeneration, a section of the journal Frontiers in Neuroscience
These authors have contributed equally to this work
Reviewed by: Pedro Domingos, Institute of Chemical and Biological Technology, New University of Lisbon, Portugal; Maria Xilouri, Biomedical Research Foundation of the Academy of Athens, Greece
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2019.00637