Diagnosis of ischemic small bowel disease by measurement of serum intestinal fatty acid-binding protein in patients with acute abdomen : a multicenter, observer-blinded validation study
Background Intestinal fatty acid-binding protein (I-FABP) is a low-molecular-mass (15 kDa) cytosolic protein found exclusively in the epithelial cells of the small bowel mucosa. We aimed to evaluate the clinical usefulness of serum I-FABP measurement for the diagnosis of ischemic small bowel disease...
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| Vydané v: | Journal of gastroenterology Ročník 46; číslo 4; s. 492 - 500 |
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| Hlavní autori: | , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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Japan
Springer Japan
01.04.2011
Springer Springer Nature B.V |
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| ISSN: | 0944-1174, 1435-5922, 1435-5922 |
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| Abstract | Background
Intestinal fatty acid-binding protein (I-FABP) is a low-molecular-mass (15 kDa) cytosolic protein found exclusively in the epithelial cells of the small bowel mucosa. We aimed to evaluate the clinical usefulness of serum I-FABP measurement for the diagnosis of ischemic small bowel disease.
Methods
Patients with a clinical diagnosis of acute abdomen were recruited for this multicenter trial at one university hospital and nine city hospitals over a 13-month period. Serum I-FABP levels were measured in 361 eligible patients by an enzyme-linked immunosorbent assay using a specific monoclonal antibody.
Results
Of the 361 patients, 242 underwent surgery, and small bowel ischemia was diagnosed in 52 patients. The mean serum I-FABP level in the patients with small bowel ischemia was 40.7 ± 117.9 ng/ml, which was significantly higher than that in patients with non-ischemic small bowel disease (5.8 ± 15.6 ng/ml) and those with non-small bowel disease (1.8 ± 1.7 ng/ml). The serum I-FABP cutoff level for the diagnosis of small bowel ischemia was 3.1 ng/ml. Serum I-FABP was more efficient than conventional biochemical markers, in terms of sensitivity and positive and negative predictive values, in the diagnosis of small bowel ischemia. However, its specificity was slightly lower than that of creatinine phosphokinase or lactate dehydrogenase. The positive and negative likelihood ratios of serum I-FABP were 3.01 and 0.29, respectively.
Conclusion
Serum I-FABP measurement is a non-invasive method that is potentially useful for the efficient identification of patients with acute abdomen who are at risk of small bowel ischemia. |
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| AbstractList | Intestinal fatty acid-binding protein (I-FABP) is a low-molecular-mass (15 kDa) cytosolic protein found exclusively in the epithelial cells of the small bowel mucosa. We aimed to evaluate the clinical usefulness of serum I-FABP measurement for the diagnosis of ischemic small bowel disease.BACKGROUNDIntestinal fatty acid-binding protein (I-FABP) is a low-molecular-mass (15 kDa) cytosolic protein found exclusively in the epithelial cells of the small bowel mucosa. We aimed to evaluate the clinical usefulness of serum I-FABP measurement for the diagnosis of ischemic small bowel disease.Patients with a clinical diagnosis of acute abdomen were recruited for this multicenter trial at one university hospital and nine city hospitals over a 13-month period. Serum I-FABP levels were measured in 361 eligible patients by an enzyme-linked immunosorbent assay using a specific monoclonal antibody.METHODSPatients with a clinical diagnosis of acute abdomen were recruited for this multicenter trial at one university hospital and nine city hospitals over a 13-month period. Serum I-FABP levels were measured in 361 eligible patients by an enzyme-linked immunosorbent assay using a specific monoclonal antibody.Of the 361 patients, 242 underwent surgery, and small bowel ischemia was diagnosed in 52 patients. The mean serum I-FABP level in the patients with small bowel ischemia was 40.7 ± 117.9 ng/ml, which was significantly higher than that in patients with non-ischemic small bowel disease (5.8 ± 15.6 ng/ml) and those with non-small bowel disease (1.8 ± 1.7 ng/ml). The serum I-FABP cutoff level for the diagnosis of small bowel ischemia was 3.1 ng/ml. Serum I-FABP was more efficient than conventional biochemical markers, in terms of sensitivity and positive and negative predictive values, in the diagnosis of small bowel ischemia. However, its specificity was slightly lower than that of creatinine phosphokinase or lactate dehydrogenase. The positive and negative likelihood ratios of serum I-FABP were 3.01 and 0.29, respectively.RESULTSOf the 361 patients, 242 underwent surgery, and small bowel ischemia was diagnosed in 52 patients. The mean serum I-FABP level in the patients with small bowel ischemia was 40.7 ± 117.9 ng/ml, which was significantly higher than that in patients with non-ischemic small bowel disease (5.8 ± 15.6 ng/ml) and those with non-small bowel disease (1.8 ± 1.7 ng/ml). The serum I-FABP cutoff level for the diagnosis of small bowel ischemia was 3.1 ng/ml. Serum I-FABP was more efficient than conventional biochemical markers, in terms of sensitivity and positive and negative predictive values, in the diagnosis of small bowel ischemia. However, its specificity was slightly lower than that of creatinine phosphokinase or lactate dehydrogenase. The positive and negative likelihood ratios of serum I-FABP were 3.01 and 0.29, respectively.Serum I-FABP measurement is a non-invasive method that is potentially useful for the efficient identification of patients with acute abdomen who are at risk of small bowel ischemia.CONCLUSIONSerum I-FABP measurement is a non-invasive method that is potentially useful for the efficient identification of patients with acute abdomen who are at risk of small bowel ischemia. Intestinal fatty acid-binding protein (I-FABP) is a low-molecular-mass (15 kDa) cytosolic protein found exclusively in the epithelial cells of the small bowel mucosa. We aimed to evaluate the clinical usefulness of serum I-FABP measurement for the diagnosis of ischemic small bowel disease. Patients with a clinical diagnosis of acute abdomen were recruited for this multicenter trial at one university hospital and nine city hospitals over a 13-month period. Serum I-FABP levels were measured in 361 eligible patients by an enzyme-linked immunosorbent assay using a specific monoclonal antibody. Of the 361 patients, 242 underwent surgery, and small bowel ischemia was diagnosed in 52 patients. The mean serum I-FABP level in the patients with small bowel ischemia was 40.7 ± 117.9 ng/ml, which was significantly higher than that in patients with non-ischemic small bowel disease (5.8 ± 15.6 ng/ml) and those with non-small bowel disease (1.8 ± 1.7 ng/ml). The serum I-FABP cutoff level for the diagnosis of small bowel ischemia was 3.1 ng/ml. Serum I-FABP was more efficient than conventional biochemical markers, in terms of sensitivity and positive and negative predictive values, in the diagnosis of small bowel ischemia. However, its specificity was slightly lower than that of creatinine phosphokinase or lactate dehydrogenase. The positive and negative likelihood ratios of serum I-FABP were 3.01 and 0.29, respectively. Serum I-FABP measurement is a non-invasive method that is potentially useful for the efficient identification of patients with acute abdomen who are at risk of small bowel ischemia.[PUBLICATION ABSTRACT] Intestinal fatty acid-binding protein (I-FABP) is a low-molecular-mass (15 kDa) cytosolic protein found exclusively in the epithelial cells of the small bowel mucosa. We aimed to evaluate the clinical usefulness of serum I-FABP measurement for the diagnosis of ischemic small bowel disease. Patients with a clinical diagnosis of acute abdomen were recruited for this multicenter trial at one university hospital and nine city hospitals over a 13-month period. Serum I-FABP levels were measured in 361 eligible patients by an enzyme-linked immunosorbent assay using a specific monoclonal antibody. Of the 361 patients, 242 underwent surgery, and small bowel ischemia was diagnosed in 52 patients. The mean serum I-FABP level in the patients with small bowel ischemia was 40.7 ± 117.9 ng/ml, which was significantly higher than that in patients with non-ischemic small bowel disease (5.8 ± 15.6 ng/ml) and those with non-small bowel disease (1.8 ± 1.7 ng/ml). The serum I-FABP cutoff level for the diagnosis of small bowel ischemia was 3.1 ng/ml. Serum I-FABP was more efficient than conventional biochemical markers, in terms of sensitivity and positive and negative predictive values, in the diagnosis of small bowel ischemia. However, its specificity was slightly lower than that of creatinine phosphokinase or lactate dehydrogenase. The positive and negative likelihood ratios of serum I-FABP were 3.01 and 0.29, respectively. Serum I-FABP measurement is a non-invasive method that is potentially useful for the efficient identification of patients with acute abdomen who are at risk of small bowel ischemia. Intestinal fatty acid-binding protein (I-FABP) is a low-molecular-mass (15 kDa) cytosolic protein found exclusively in the epithelial cells of the small bowel mucosa. We aimed to evaluate the clinical usefulness of serum I-FABP measurement for the diagnosis of ischemic small bowel disease. Of the 361 patients, 242 underwent surgery, and small bowel ischemia was diagnosed in 52 patients. The mean serum I-FABP level in the patients with small bowel ischemia was 40.7 ± 117.9 ng/ml, which was significantly higher than that in patients with non-ischemic small bowel disease (5.8 ± 15.6 ng/ml) and those with non-small bowel disease (1.8 ± 1.7 ng/ml). The serum I-FABP cutoff level for the diagnosis of small bowel ischemia was 3.1 ng/ml. Serum I-FABP was more efficient than conventional biochemical markers, in terms of sensitivity and positive and negative predictive values, in the diagnosis of small bowel ischemia. However, its specificity was slightly lower than that of creatinine phosphokinase or lactate dehydrogenase. The positive and negative likelihood ratios of serum I-FABP were 3.01 and 0.29, respectively. Serum I-FABP measurement is a non-invasive method that is potentially useful for the efficient identification of patients with acute abdomen who are at risk of small bowel ischemia. Background Intestinal fatty acid-binding protein (I-FABP) is a low-molecular-mass (15 kDa) cytosolic protein found exclusively in the epithelial cells of the small bowel mucosa. We aimed to evaluate the clinical usefulness of serum I-FABP measurement for the diagnosis of ischemic small bowel disease. Methods Patients with a clinical diagnosis of acute abdomen were recruited for this multicenter trial at one university hospital and nine city hospitals over a 13-month period. Serum I-FABP levels were measured in 361 eligible patients by an enzyme-linked immunosorbent assay using a specific monoclonal antibody. Results Of the 361 patients, 242 underwent surgery, and small bowel ischemia was diagnosed in 52 patients. The mean serum I-FABP level in the patients with small bowel ischemia was 40.7 ± 117.9 ng/ml, which was significantly higher than that in patients with non-ischemic small bowel disease (5.8 ± 15.6 ng/ml) and those with non-small bowel disease (1.8 ± 1.7 ng/ml). The serum I-FABP cutoff level for the diagnosis of small bowel ischemia was 3.1 ng/ml. Serum I-FABP was more efficient than conventional biochemical markers, in terms of sensitivity and positive and negative predictive values, in the diagnosis of small bowel ischemia. However, its specificity was slightly lower than that of creatinine phosphokinase or lactate dehydrogenase. The positive and negative likelihood ratios of serum I-FABP were 3.01 and 0.29, respectively. Conclusion Serum I-FABP measurement is a non-invasive method that is potentially useful for the efficient identification of patients with acute abdomen who are at risk of small bowel ischemia. Background Intestinal fatty acid-binding protein (I-FABP) is a low-molecular-mass (15 kDa) cytosolic protein found exclusively in the epithelial cells of the small bowel mucosa. We aimed to evaluate the clinical usefulness of serum I-FABP measurement for the diagnosis of ischemic small bowel disease. Methods Patients with a clinical diagnosis of acute abdomen were recruited for this multicenter trial at one university hospital and nine city hospitals over a 13-month period. Serum I-FABP levels were measured in 361 eligible patients by an enzyme-linked immunosorbent assay using a specific monoclonal antibody. Results Of the 361 patients, 242 underwent surgery, and small bowel ischemia was diagnosed in 52 patients. The mean serum I-FABP level in the patients with small bowel ischemia was 40.7 ± 117.9 ng/ml, which was significantly higher than that in patients with non-ischemic small bowel disease (5.8 ± 15.6 ng/ml) and those with non-small bowel disease (1.8 ± 1.7 ng/ml). The serum I-FABP cutoff level for the diagnosis of small bowel ischemia was 3.1 ng/ml. Serum I-FABP was more efficient than conventional biochemical markers, in terms of sensitivity and positive and negative predictive values, in the diagnosis of small bowel ischemia. However, its specificity was slightly lower than that of creatinine phosphokinase or lactate dehydrogenase. The positive and negative likelihood ratios of serum I-FABP were 3.01 and 0.29, respectively. Conclusion Serum I-FABP measurement is a non-invasive method that is potentially useful for the efficient identification of patients with acute abdomen who are at risk of small bowel ischemia. |
| Audience | Academic |
| Author | HATAKEYAMA Katsuyoshi TSUKAHARA Akihiro YAMAZAKI Toshiyuki UEKI Kyo FUNAOKA Hiroyuki SAKAI Yasuo KANDA Tatsuo HIROTA Masaki TANI Tatsuo TADA Tetsuya NISHIMURA Atsushi HASEGAWA Jun TAMIYA Yoichi FUJII Hiroshi |
| Author_xml | – sequence: 1 givenname: Tatsuo surname: Kanda fullname: Kanda, Tatsuo email: kandat@med.niigata-u.ac.jp organization: Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences – sequence: 2 givenname: Akihiro surname: Tsukahara fullname: Tsukahara, Akihiro organization: Department of Surgery, Niigata Prefecture Shibata Hospital – sequence: 3 givenname: Kyo surname: Ueki fullname: Ueki, Kyo organization: Department of Surgery, Kariwagun General Hospital – sequence: 4 givenname: Yasuo surname: Sakai fullname: Sakai, Yasuo organization: Department of Surgery, Saiseikai Niigata Daini Hospital – sequence: 5 givenname: Tatsuo surname: Tani fullname: Tani, Tatsuo organization: Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences – sequence: 6 givenname: Atsushi surname: Nishimura fullname: Nishimura, Atsushi organization: Department of Surgery, Nagaoka Chuo General Hospital – sequence: 7 givenname: Toshiyuki surname: Yamazaki fullname: Yamazaki, Toshiyuki organization: Department of Surgery, Niigata City General Hospital – sequence: 8 givenname: Yoichi surname: Tamiya fullname: Tamiya, Yoichi organization: Department of Surgery, Niigata Prefecture Yoshida Hospital – sequence: 9 givenname: Tetsuya surname: Tada fullname: Tada, Tetsuya organization: Department of Surgery, Tachikawa General Hospital – sequence: 10 givenname: Masaki surname: Hirota fullname: Hirota, Masaki organization: Department of Surgery, Niigata Prefecture Muikamachi Hospital – sequence: 11 givenname: Jun surname: Hasegawa fullname: Hasegawa, Jun organization: Department of Surgery, Japanese Red Cross Nagaoka Hospital – sequence: 12 givenname: Hiroyuki surname: Funaoka fullname: Funaoka, Hiroyuki organization: DS Pharma Biomedical Co., Ltd – sequence: 13 givenname: Hiroshi surname: Fujii fullname: Fujii, Hiroshi organization: Department of Bioscience and Biotechnology, Shinshu University – sequence: 14 givenname: Katsuyoshi surname: Hatakeyama fullname: Hatakeyama, Katsuyoshi organization: Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences |
| BackLink | https://cir.nii.ac.jp/crid/1571417124973663872$$DView record in CiNii https://www.ncbi.nlm.nih.gov/pubmed/21298292$$D View this record in MEDLINE/PubMed |
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| Keywords | Acute abdomen I-FABP Biomarker Intestinal ischemia ELISA |
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| References_xml | – volume: 28 start-page: 63 year: 2004 end-page: 68 ident: CR21 article-title: Usefulness of known computed tomography and clinical criteria for diagnosing strangulation in small-bowel obstructions: analysis of true and false interpretation groups in computed tomography publication-title: World J Surg doi: 10.1007/s00268-003-6899-6 – volume: 110 start-page: 339 year: 1996 end-page: 343 ident: CR10 article-title: Intestinal fatty acid-binding protein is a useful diagnostic marker for mesenteric infarction in humans publication-title: Gastroenterology doi: 10.1053/gast.1996.v110.pm8566578 – volume: 114 start-page: 206 year: 1993 end-page: 210 ident: CR11 article-title: Biochemical detection of small intestinal allograft rejection by elevated circulating levels of serum intestinal fatty acid-binding protein publication-title: Surgery – volume: 33 start-page: 1374 year: 2009 end-page: 1383 ident: CR4 article-title: Systematic review and pooled estimates for the diagnostic accuracy of serological markers for intestinal ischemia publication-title: World J Surg doi: 10.1007/s00268-009-0074-7 – volume: 21 start-page: 201 year: 2005 end-page: 215 ident: CR3 article-title: Review article: diagnosis and management of mesenteric ischemia with an emphasis on pharmacotherapy publication-title: Aliment Pharmacol Ther doi: 10.1111/j.1365-2036.2005.02269.x – volume: 248 start-page: 117 year: 2008 end-page: 125 ident: CR20 article-title: Visceral injury and systemic inflammation in patients undergoing extracorporeal circulation during aortic surgery publication-title: Ann Surg doi: 10.1097/SLA.0b013e3181784cc5 – volume: 37 start-page: 1362 year: 1992 end-page: 1367 ident: CR8 article-title: Intestinal fatty acid-binding protein as a sensitive marker of intestinal ischemia publication-title: Dig Dis Sci doi: 10.1007/BF01296004 – volume: 28 start-page: 367 year: 1993 end-page: 370 ident: CR13 article-title: Elevation of circulating intestinal fatty acid-binding protein in a luminal contents-initiated model of NEC publication-title: J Pediatr Surg doi: 10.1016/0022-3468(93)90233-B – volume: 14 start-page: 2347 year: 2004 end-page: 2356 ident: CR22 article-title: Accuracy of multidetector row computed tomography for the diagnosis of acute bowel ischemia in a non-selected study population publication-title: Eur Radiol doi: 10.1007/s00330-004-2462-6 – volume: 147 start-page: 25 year: 2008 end-page: 28 ident: CR15 article-title: Intestinal fatty acid-binding protein (I-FABP) as a possible biomarker of ileitis in patients with ulcerative colitis publication-title: Regul Pept doi: 10.1016/j.regpep.2007.12.002 – volume: 44 start-page: 763 year: 1991 end-page: 770 ident: CR19 article-title: Likelihood ratios with confidence: sample size estimation for diagnostic test studies publication-title: J Clin Epidemiol doi: 10.1016/0895-4356(91)90128-V – volume: 37 start-page: 1 year: 2007 end-page: 332 ident: CR24 publication-title: Ann ICRP – volume: 61 start-page: 1451 year: 1996 end-page: 1455 ident: CR12 article-title: Small bowel allograft rejection detected by serum intestinal fatty acid-binding protein is reversible publication-title: Transplantation doi: 10.1097/00007890-199605270-00006 – volume: 40 start-page: 1 year: 2011 end-page: 20 ident: CR17 article-title: Development of a high-specificity sandwich ELISA system for the quantification of human intestinal fatty acid-binding protein (I-FABP) concentrations publication-title: Immunol Invest doi: 10.3109/08820139.2010.534216 – ident: CR25 – volume: 36 start-page: 788 year: 1995 end-page: 791 ident: CR9 article-title: Intestinal fatty acid-binding protein is available for diagnosis of intestinal ischaemia: immunochemical analysis of two patients with ischaemic intestinal diseases publication-title: Gut doi: 10.1136/gut.36.5.788 – volume: 169 start-page: 2071 year: 2009 end-page: 2077 ident: CR23 article-title: Projected cancer risks from computed tomographic scans performed in the United States in 2007 publication-title: Arch Intern Med doi: 10.1001/archinternmed.2009.440 – volume: 17 start-page: 2635 year: 1998 end-page: 2650 ident: CR18 article-title: Improved confidence intervals for the difference between binomial proportions based on paired data publication-title: Stat Med doi: 10.1002/(SICI)1097-0258(19981130)17:22<2635::AID-SIM954>3.0.CO;2-C – volume: 239 start-page: 227 year: 2002 end-page: 234 ident: CR14 article-title: Plasma concentration of intestinal- and liver-FABP in neonates suffering from necrotizing enterocolitis and in healthy preterm neonates publication-title: Mol Cell Biochem doi: 10.1023/A:1020508420058 – volume: 36 start-page: 529 year: 2003 end-page: 535 ident: CR7 article-title: Intestinal-type and liver-type fatty acid-binding protein in the intestine. Tissue distribution and clinical utility publication-title: Clin Biochem doi: 10.1016/S0009-9120(03)00096-1 – volume: 18 start-page: 158 year: 2007 end-page: 166 ident: CR1 article-title: Prevention of gastrointestinal complications in the critically ill patients publication-title: AACN Adv Crit Care doi: 10.1097/01.AACN.0000269259.91546.d8 – volume: 81 start-page: 313 year: 1984 end-page: 317 ident: CR5 article-title: Cloning of a cDNA encoding rat intestinal fatty acid-binding protein publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.81.2.313 – volume: 29 start-page: 19 year: 2008 end-page: 41 ident: CR16 article-title: Establishment and characterization of monoclonal and polyclonal antibodies against human intestinal fatty acid-binding protein (I-FABP) using synthetic regional peptides and recombinant I-FABP publication-title: J Immunoassay Immunochem doi: 10.1080/15321810701735005 – volume: 50 start-page: 37 year: 2004 end-page: 47 ident: CR2 article-title: Acute bowel ischemia: CT findings publication-title: Eur J Radiol doi: 10.1016/j.ejrad.2003.11.013 – volume: 239 start-page: 79 year: 2002 end-page: 82 ident: CR6 article-title: Intracellular lipid binding proteins of the small intestine publication-title: Mol Cell Biochem doi: 10.1023/A:1020520521025 – volume: 248 start-page: 117 year: 2008 ident: 373_CR20 publication-title: Ann Surg doi: 10.1097/SLA.0b013e3181784cc5 – volume: 44 start-page: 763 year: 1991 ident: 373_CR19 publication-title: J Clin Epidemiol doi: 10.1016/0895-4356(91)90128-V – volume: 37 start-page: 1362 year: 1992 ident: 373_CR8 publication-title: Dig Dis Sci doi: 10.1007/BF01296004 – volume: 169 start-page: 2071 year: 2009 ident: 373_CR23 publication-title: Arch Intern Med doi: 10.1001/archinternmed.2009.440 – volume: 239 start-page: 227 year: 2002 ident: 373_CR14 publication-title: Mol Cell Biochem doi: 10.1023/A:1020508420058 – ident: 373_CR25 – volume: 81 start-page: 313 year: 1984 ident: 373_CR5 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.81.2.313 – volume: 114 start-page: 206 year: 1993 ident: 373_CR11 publication-title: Surgery – volume: 61 start-page: 1451 year: 1996 ident: 373_CR12 publication-title: Transplantation doi: 10.1097/00007890-199605270-00006 – volume: 18 start-page: 158 year: 2007 ident: 373_CR1 publication-title: AACN Adv Crit Care doi: 10.1097/01.AACN.0000269259.91546.d8 – volume: 36 start-page: 529 year: 2003 ident: 373_CR7 publication-title: Clin Biochem doi: 10.1016/S0009-9120(03)00096-1 – volume: 17 start-page: 2635 year: 1998 ident: 373_CR18 publication-title: Stat Med doi: 10.1002/(SICI)1097-0258(19981130)17:22<2635::AID-SIM954>3.0.CO;2-C – volume: 239 start-page: 79 year: 2002 ident: 373_CR6 publication-title: Mol Cell Biochem doi: 10.1023/A:1020520521025 – volume: 28 start-page: 63 year: 2004 ident: 373_CR21 publication-title: World J Surg doi: 10.1007/s00268-003-6899-6 – volume: 40 start-page: 1 year: 2011 ident: 373_CR17 publication-title: Immunol Invest doi: 10.3109/08820139.2010.504803 – ident: 373_CR24 doi: 10.1016/j.icrp.2008.07.001 – volume: 28 start-page: 367 year: 1993 ident: 373_CR13 publication-title: J Pediatr Surg doi: 10.1016/0022-3468(93)90233-B – volume: 147 start-page: 25 year: 2008 ident: 373_CR15 publication-title: Regul Pept doi: 10.1016/j.regpep.2007.12.002 – volume: 14 start-page: 2347 year: 2004 ident: 373_CR22 publication-title: Eur Radiol doi: 10.1007/s00330-004-2462-6 – volume: 110 start-page: 339 year: 1996 ident: 373_CR10 publication-title: Gastroenterology doi: 10.1053/gast.1996.v110.pm8566578 – volume: 21 start-page: 201 year: 2005 ident: 373_CR3 publication-title: Aliment Pharmacol Ther doi: 10.1111/j.1365-2036.2005.02269.x – volume: 33 start-page: 1374 year: 2009 ident: 373_CR4 publication-title: World J Surg doi: 10.1007/s00268-009-0074-7 – volume: 29 start-page: 19 year: 2008 ident: 373_CR16 publication-title: J Immunoassay Immunochem doi: 10.1080/15321810701735005 – volume: 50 start-page: 37 year: 2004 ident: 373_CR2 publication-title: Eur J Radiol doi: 10.1016/j.ejrad.2003.11.013 – volume: 36 start-page: 788 year: 1995 ident: 373_CR9 publication-title: Gut doi: 10.1136/gut.36.5.788 |
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Intestinal fatty acid-binding protein (I-FABP) is a low-molecular-mass (15 kDa) cytosolic protein found exclusively in the epithelial cells of the... Intestinal fatty acid-binding protein (I-FABP) is a low-molecular-mass (15 kDa) cytosolic protein found exclusively in the epithelial cells of the small bowel... Background Intestinal fatty acid-binding protein (I-FABP) is a low-molecular-mass (15 kDa) cytosolic protein found exclusively in the epithelial cells of the... |
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| Title | Diagnosis of ischemic small bowel disease by measurement of serum intestinal fatty acid-binding protein in patients with acute abdomen : a multicenter, observer-blinded validation study |
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