Clinical Characteristics and Prognostic Risk Factors of Parasellar Chondrosarcoma

Background: Parasellar chondrosarcomas are extremely rare. This study describes the characteristics of parasellar chondrosarcoma and analyzes the risk factors and prognosis based on the resection degree. Methods: Fifteen patients with pathologically diagnosed parasellar chondrosarcoma were retrospec...

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Published in:Brain sciences Vol. 12; no. 10; p. 1353
Main Authors: Zhang, Linpeng, Wang, Chen, Qi, Xueling, Zhang, Xufei, Yan, Changxiang, Liu, Ning, Yang, Yakun, Ren, Ming, Liu, Yabo, Fu, Xiaojun, Han, Song, Zeng, Xianwei
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 06.10.2022
MDPI
Subjects:
Alcohol
Antibodies
Antigens
Brain cancer
Calcification
Chondrosarcoma
clinical features
Correlation analysis
Diplopia
imaging features
Magnetic resonance imaging
Medical prognosis
Metastasis
parasellar chondrosarcoma
pathology
Patients
Prognosis
Quality of life
Risk factors
Software
Tumors
Beijing China
United Kingdom > UK
United States > US
China
Germany
parasellar chondrosarcoma
pathology
prognosis
clinical features
imaging features
ISSN:2076-3425, 2076-3425
Online Access:Get full text
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Summary:Background: Parasellar chondrosarcomas are extremely rare. This study describes the characteristics of parasellar chondrosarcoma and analyzes the risk factors and prognosis based on the resection degree. Methods: Fifteen patients with pathologically diagnosed parasellar chondrosarcoma were retrospectively analyzed for the clinical data, surgical methods, and prognosis to identify relationships between the surgical resection degree, tumor recurrence, and imaging characteristics. Results: Twelve patients had eye dysfunction and ptosis. Differentiation from other parasellar tumors by imaging is difficult. The preoperative Karnofsky Performance Scale (KPS) score positively correlated with the tumor resection degree (p = 0.026) and negatively correlated with the maximum tumor diameter (p = 0.001). Tumor recurrence negatively correlated with the resection degree (p = 0.009). The postoperative KPS score positively correlated with the preoperative KPS score (p < 0.001) and tumor resection degree (p = 0.026), and negatively correlated with the maximum tumor diameter (p = 0.016) and age (p = 0.047). An improved KPS score positively correlated with the tumor resection degree (p = 0.039). Patients who underwent total resection of the chondrosarcoma had longer progression-free survival than those who underwent partial resection (p = 0.0322). Conclusion: Parasellar chondrosarcomas are difficult to resect completely. Preoperative KPS score is an important factor for the degree of resection. KPS score, age, maximum tumor diameter, and resection degree may be important prognostic factors.
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These authors contributed equally to this work.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci12101353