Blood Group Testing

Red blood cell (RBC) transfusion is one of the most frequently performed clinical procedures and therapies to improve tissue oxygen delivery in hospitalized patients worldwide. Generally, the cross-match is the mandatory test in place to meet the clinical needs of RBC transfusion by examining donor-...

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Bibliographic Details
Published in:Frontiers in medicine Vol. 9; p. 827619
Main Authors: Li, Hong-Yang, Guo, Kai
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media SA 11.02.2022
Frontiers Media S.A
Subjects:
ABO blood group system
Antibodies
Antigens
Blood & organ donations
blood group antigen
blood group testing
blood group typing
Blood groups
Blood transfusions
Genes
Immune response
Immunoglobulins
Leukemia
Medicine
Patient safety
Reagents
red blood cell
RH blood group system
Serology
Terminology
ABO blood group system
blood group antigen
blood group typing
blood group testing
RH blood group system
red blood cell
ISSN:2296-858X, 2296-858X
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Summary:Red blood cell (RBC) transfusion is one of the most frequently performed clinical procedures and therapies to improve tissue oxygen delivery in hospitalized patients worldwide. Generally, the cross-match is the mandatory test in place to meet the clinical needs of RBC transfusion by examining donor-recipient compatibility with antigens and antibodies of blood groups. Blood groups are usually an individual's combination of antigens on the surface of RBCs, typically of the ABO blood group system and the RH blood group system. Accurate and reliable blood group typing is critical before blood transfusion. Serological testing is the routine method for blood group typing based on hemagglutination reactions with RBC antigens against specific antibodies. Nevertheless, emerging technologies for blood group testing may be alternative and supplemental approaches when serological methods cannot determine blood groups. Moreover, some new technologies, such as the evolving applications of blood group genotyping, can precisely identify variant antigens for clinical significance. Therefore, this review mainly presents a clinical overview and perspective of emerging technologies in blood group testing based on the literature. Collectively, this may highlight the most promising strategies and promote blood group typing development to ensure blood transfusion safety.
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This article was submitted to Hematology, a section of the journal Frontiers in Medicine
Reviewed by: Massimo Franchini, Azienda Ospedaliera Carlo Poma, Italy; Anastasios G. Kriebardis, University of West Attica, Greece
Edited by: Thierry Burnouf, Taipei Medical University, Taiwan
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2022.827619