Pericytes and Neurovascular Function in the Healthy and Diseased Brain
Pericytes are multi-functional cells embedded within the walls of capillaries throughout the body, including the brain. Pericytes were first identified in the 1870s, but little attention was paid to them during the following century. More recently, numerous vascular functions of pericytes have been...
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| Veröffentlicht in: | Frontiers in cellular neuroscience Jg. 13; S. 282 |
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| Hauptverfasser: | , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
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Frontiers Research Foundation
28.06.2019
Frontiers Media S.A |
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| ISSN: | 1662-5102, 1662-5102 |
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| Abstract | Pericytes are multi-functional cells embedded within the walls of capillaries throughout the body, including the brain. Pericytes were first identified in the 1870s, but little attention was paid to them during the following century. More recently, numerous vascular functions of pericytes have been identified including regulation of cerebral blood flow, maintenance of the blood-brain barrier (BBB), and control of vascular development and angiogenesis. Pericytes can also facilitate neuroinflammatory processes and possess stem cell-like properties. Pericytes form part of the neurovascular unit (NVU), a collection of cells that control interactions between neurons and the cerebral vasculature to meet the energy demands of the brain. Pericyte structure, expression profile, and function in the brain differ depending on their location along the vascular bed. Until recently, it has been difficult to accurately define the sub-types of pericytes, or to specifically target pericytes with pharmaceutical agents, but emerging techniques both
and
will improve investigation of pericytes and allow for the identification of their possible roles in diseases. Pericyte dysfunction is increasingly recognized as a contributor to the progression of vascular diseases such as stroke and neurodegenerative diseases such as Alzheimer's disease. The therapeutic potential of pericytes to repair cerebral blood vessels and promote angiogenesis due to their ability to behave like stem cells has recently been brought to light. Here, we review the history of pericyte research, the present techniques used to study pericytes in the brain, and current research advancements to characterize and therapeutically target pericytes in the future. |
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| AbstractList | Pericytes are multi-functional cells embedded within the walls of capillaries throughout the body, including the brain. Pericytes were first identified in the 1870s, but little attention was paid to them during the following century. More recently, numerous vascular functions of pericytes have been identified including regulation of cerebral blood flow, maintenance of the blood-brain barrier (BBB), and control of vascular development and angiogenesis. Pericytes can also facilitate neuroinflammatory processes and possess stem cell-like properties. Pericytes form part of the neurovascular unit (NVU), a collection of cells that control interactions between neurons and the cerebral vasculature to meet the energy demands of the brain. Pericyte structure, expression profile, and function in the brain differ depending on their location along the vascular bed. Until recently, it has been difficult to accurately define the sub-types of pericytes, or to specifically target pericytes with pharmaceutical agents, but emerging techniques both in vitro and in vivo will improve investigation of pericytes and allow for the identification of their possible roles in diseases. Pericyte dysfunction is increasingly recognized as a contributor to the progression of vascular diseases such as stroke and neurodegenerative diseases such as Alzheimer’s disease. The therapeutic potential of pericytes to repair cerebral blood vessels and promote angiogenesis due to their ability to behave like stem cells has recently been brought to light. Here, we review the history of pericyte research, the present techniques used to study pericytes in the brain, and current research advancements to characterize and therapeutically target pericytes in the future. Pericytes are multi-functional cells embedded within the walls of capillaries throughout the body, including the brain. Pericytes were first identified in the 1870s, but little attention was paid to them during the following century. More recently, numerous vascular functions of pericytes have been identified including regulation of cerebral blood flow, maintenance of the blood-brain barrier, and control of vascular development and angiogenesis. Pericytes can also facilitate neuroinflammatory processes and possess stem cell-like properties. Pericytes form part of the neurovascular unit, a collection of cells that control interactions between neurons and the cerebral vasculature to meet the energy demands of the brain. Pericyte structure, expression profile, and function in the brain differ depending on their location along the vascular bed. Until recently, it has been difficult to accurately define the sub-types of pericytes, or to specifically target pericytes with pharmaceutical agents, but emerging techniques both in vitro and in vivo will improve investigation of pericytes and allow for the identification of their possible roles in diseases. Pericyte dysfunction is increasingly recognized as a contributor to the progression of vascular diseases such as stroke and neurodegenerative diseases such as Alzheimer’s disease. The therapeutic potential of pericytes to repair cerebral blood vessels and promote angiogenesis due to their ability to behave like stem cells has recently been brought to light. Here, we review the history of pericyte research, the present techniques used to study pericytes in the brain, and current research advancements to characterize and therapeutically target pericytes in the future. Pericytes are multi-functional cells embedded within the walls of capillaries throughout the body, including the brain. Pericytes were first identified in the 1870s, but little attention was paid to them during the following century. More recently, numerous vascular functions of pericytes have been identified including regulation of cerebral blood flow, maintenance of the blood-brain barrier (BBB), and control of vascular development and angiogenesis. Pericytes can also facilitate neuroinflammatory processes and possess stem cell-like properties. Pericytes form part of the neurovascular unit (NVU), a collection of cells that control interactions between neurons and the cerebral vasculature to meet the energy demands of the brain. Pericyte structure, expression profile, and function in the brain differ depending on their location along the vascular bed. Until recently, it has been difficult to accurately define the sub-types of pericytes, or to specifically target pericytes with pharmaceutical agents, but emerging techniques both and will improve investigation of pericytes and allow for the identification of their possible roles in diseases. Pericyte dysfunction is increasingly recognized as a contributor to the progression of vascular diseases such as stroke and neurodegenerative diseases such as Alzheimer's disease. The therapeutic potential of pericytes to repair cerebral blood vessels and promote angiogenesis due to their ability to behave like stem cells has recently been brought to light. Here, we review the history of pericyte research, the present techniques used to study pericytes in the brain, and current research advancements to characterize and therapeutically target pericytes in the future. Pericytes are multi-functional cells embedded within the walls of capillaries throughout the body, including the brain. Pericytes were first identified in the 1870s, but little attention was paid to them during the following century. More recently, numerous vascular functions of pericytes have been identified including regulation of cerebral blood flow, maintenance of the blood-brain barrier (BBB), and control of vascular development and angiogenesis. Pericytes can also facilitate neuroinflammatory processes and possess stem cell-like properties. Pericytes form part of the neurovascular unit (NVU), a collection of cells that control interactions between neurons and the cerebral vasculature to meet the energy demands of the brain. Pericyte structure, expression profile, and function in the brain differ depending on their location along the vascular bed. Until recently, it has been difficult to accurately define the sub-types of pericytes, or to specifically target pericytes with pharmaceutical agents, but emerging techniques both in vitro and in vivo will improve investigation of pericytes and allow for the identification of their possible roles in diseases. Pericyte dysfunction is increasingly recognized as a contributor to the progression of vascular diseases such as stroke and neurodegenerative diseases such as Alzheimer's disease. The therapeutic potential of pericytes to repair cerebral blood vessels and promote angiogenesis due to their ability to behave like stem cells has recently been brought to light. Here, we review the history of pericyte research, the present techniques used to study pericytes in the brain, and current research advancements to characterize and therapeutically target pericytes in the future.Pericytes are multi-functional cells embedded within the walls of capillaries throughout the body, including the brain. Pericytes were first identified in the 1870s, but little attention was paid to them during the following century. More recently, numerous vascular functions of pericytes have been identified including regulation of cerebral blood flow, maintenance of the blood-brain barrier (BBB), and control of vascular development and angiogenesis. Pericytes can also facilitate neuroinflammatory processes and possess stem cell-like properties. Pericytes form part of the neurovascular unit (NVU), a collection of cells that control interactions between neurons and the cerebral vasculature to meet the energy demands of the brain. Pericyte structure, expression profile, and function in the brain differ depending on their location along the vascular bed. Until recently, it has been difficult to accurately define the sub-types of pericytes, or to specifically target pericytes with pharmaceutical agents, but emerging techniques both in vitro and in vivo will improve investigation of pericytes and allow for the identification of their possible roles in diseases. Pericyte dysfunction is increasingly recognized as a contributor to the progression of vascular diseases such as stroke and neurodegenerative diseases such as Alzheimer's disease. The therapeutic potential of pericytes to repair cerebral blood vessels and promote angiogenesis due to their ability to behave like stem cells has recently been brought to light. Here, we review the history of pericyte research, the present techniques used to study pericytes in the brain, and current research advancements to characterize and therapeutically target pericytes in the future. |
| Author | Howells, David W. Brown, Lachlan S. Foster, Catherine G. Courtney, Jo-Maree King, Natalie E. Sutherland, Brad A. |
| AuthorAffiliation | School of Medicine, College of Health and Medicine, University of Tasmania , Hobart, TAS , Australia |
| AuthorAffiliation_xml | – name: School of Medicine, College of Health and Medicine, University of Tasmania , Hobart, TAS , Australia |
| Author_xml | – sequence: 1 givenname: Lachlan S. surname: Brown fullname: Brown, Lachlan S. – sequence: 2 givenname: Catherine G. surname: Foster fullname: Foster, Catherine G. – sequence: 3 givenname: Jo-Maree surname: Courtney fullname: Courtney, Jo-Maree – sequence: 4 givenname: Natalie E. surname: King fullname: King, Natalie E. – sequence: 5 givenname: David W. surname: Howells fullname: Howells, David W. – sequence: 6 givenname: Brad A. surname: Sutherland fullname: Sutherland, Brad A. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31316352$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1007/s11064-011-0626-8 10.1038/s41591-018-0297-y 10.1007/s00401-018-1893-0 10.1177/0271678X16676826 10.1038/nn.4489 10.7150/thno.21254 10.1074/jbc.R116.760215 10.1038/nn.4288 10.1016/j.expneurol.2017.10.023 10.7554/eLife.34861 10.1186/s13024-018-0286-0 10.1007/s00401-014-1295-x 10.1016/j.stemcr.2019.01.005 10.1038/nature05193 10.1016/j.neuron.2015.06.001 10.1016/j.mvr.2006.02.006 10.1215/s1152851705000232 10.1016/j.biomaterials.2018.07.014 10.2353/ajpath.2007.070050 10.1073/pnas.1707702115 10.1007/bf02593544 10.1016/j.neuron.2009.06.026 10.1038/nrn.2017.48 10.1002/cne.24565 10.1038/nature13165 10.1177/0271678X16659495 10.1016/j.jconrel.2010.03.015 10.1111/bpa.12004 10.1038/nm.2022 10.1016/j.vph.2016.05.009 10.1177/0271678X17732229 10.1007/s00418-014-1301-3 10.1084/jem.20051210 10.1387/ijdb.103167dr 10.1182/blood-2013-03-490763 10.1152/physrev.00050.2017 10.2147/IJN.S105274 10.2217/fon.14.123 10.1126/sciadv.aau7375 10.1002/stem.1977 10.1016/s0361-9230(99)00260-9 10.1111/bpa.12152 10.1523/JNEUROSCI.2891-16.2016 10.1038/nn.4428 10.1371/journal.pone.0150360 10.1038/nn.4564 10.1038/nature09522 10.1016/j.neuron.2010.09.043 10.1016/j.tips.2016.12.001 10.1007/s12307-012-0102-2 10.1038/nature11087 10.1016/j.devcel.2011.07.001 10.1016/j.biomaterials.2013.12.027 10.1117/1.NPh.2.4.041402 10.1186/1742-2094-11-104 10.1038/nature09613 10.1038/ncomms3932 10.1083/jcb.153.3.543 10.3389/fnene.2010.00005 10.1177/0271678X15610340 10.1177/0271678X17697720 10.3389/fnagi.2018.00210 |
| ContentType | Journal Article |
| Copyright | 2019. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2019 Brown, Foster, Courtney, King, Howells and Sutherland. 2019 Brown, Foster, Courtney, King, Howells and Sutherland |
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| Keywords | blood brain barrier cerebral blood flow neurovascular brain neurological disease pericytes |
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| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| References | Berthiaume (B11) 2018; 10 Kim (B31) 2009; 63 Rustenhoven (B48) 2017; 38 Rucker (B47) 2000; 51 Jung (B29) 2017; 38 Mishra (B38) 2016; 19 Tachibana (B55) 2018; 300 Wilhelmus (B59) 2007; 171 Vanlandewijck (B57) 2018; 14 Alarcon-Martinez (B1) 2018; 7 Jeong (B28) 2006; 71 Hamilton (B22) 2010; 2 Cheng (B14) 2018; 136 Armulik (B3) 2010; 468 Barlow (B7) 2012; 6 Hill (B26) 2015; 87 Underly (B56) 2017; 37 Attwell (B5) 2016; 36 Ozen (B42) 2014; 128 Sengillo (B50) 2013; 23 Xing (B61) 2017; 37 Kisler (B32); 18 Robertson (B45) 2015; 143 Jansson (B27) 2014; 11 Ma (B35) 2018; 13 Wang (B58) 2006; 203 Nakagomi (B39) 2015; 33 Avolio (B6) 2016; 86 Armulik (B2) 2011; 21 Farahani (B18) 2019; 527 Sagare (B49) 2013; 4 Campisi (B13) 2018; 180 Yemisci (B62) 2009; 15 Guan (B20) 2014; 5 Neuhaus (B41) 2017; 37 Bell (B9) 2012; 485 Ruan (B46) 2013; 121 Nation (B40) 2019; 25 Sweeney (B53) 2016; 19 Bell (B8) 2010; 68 Herland (B25) 2016; 11 Kang (B30) 2016; 11 Hellstrom (B24) 2001; 153 Hartmann (B23) 2015; 2 Peppiatt (B43) 2006; 443 Winkler (B60) 2014; 24 Meng (B37) 2015; 11 Shimizu (B51) 2012; 37 Loi (B34) 2010; 145 Attwell (B4) 2010; 468 Dong (B16) 2018; 8 McConnell (B36) 2017; 292 Stebbins (B52) 2019; 5 Damisah (B15) 2017; 20 Ribatti (B44) 2011; 55 Sweeney (B54) 2019; 99 Kisler (B33); 20 Bergers (B10) 2005; 7 Faal (B17) 2019; 12 Zimmermann (B63) 1923; 68 Cai (B12) 2018; 115 Hall (B21) 2014; 508 Grant (B19) 2019; 39 |
| References_xml | – volume: 37 start-page: 401 year: 2012 ident: B51 article-title: Pericyte-derived glial cell line-derived neurotrophic factor increase the expression of claudin-5 in the blood-brain barrier and the blood-nerve barrier. publication-title: Neurochem. Res. doi: 10.1007/s11064-011-0626-8 – volume: 25 start-page: 270 year: 2019 ident: B40 article-title: Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction. publication-title: Nat. Med. doi: 10.1038/s41591-018-0297-y – volume: 136 start-page: 507 year: 2018 ident: B14 article-title: Targeting pericytes for therapeutic approaches to neurological disorders. publication-title: Acta Neuropathol. doi: 10.1007/s00401-018-1893-0 – volume: 37 start-page: 2848 year: 2017 ident: B61 article-title: Distribution of cardiac output to the brain across the adult lifespan. publication-title: J. Cereb. Blood Flow Metab. doi: 10.1177/0271678X16676826 – volume: 20 start-page: 406 ident: B33 article-title: Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain. publication-title: Nat. Neurosci. doi: 10.1038/nn.4489 – volume: 8 start-page: 1481 year: 2018 ident: B16 article-title: Current strategies for brain drug delivery. publication-title: Theranostics doi: 10.7150/thno.21254 – volume: 292 start-page: 762 year: 2017 ident: B36 article-title: The translational significance of the neurovascular unit. publication-title: J. Biol. Chem. doi: 10.1074/jbc.R116.760215 – volume: 19 start-page: 771 year: 2016 ident: B53 article-title: Pericytes of the neurovascular unit: key functions and signaling pathways. publication-title: Nat. Rev. Neurosci. doi: 10.1038/nn.4288 – volume: 300 start-page: 13 year: 2018 ident: B55 article-title: Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-beta pathology in amyloid model mice. publication-title: Exp. Neurol. doi: 10.1016/j.expneurol.2017.10.023 – volume: 7 year: 2018 ident: B1 article-title: Capillary pericytes express alpha-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection. publication-title: eLife doi: 10.7554/eLife.34861 – volume: 13 year: 2018 ident: B35 article-title: Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism. publication-title: Mol. Neurodegener. doi: 10.1186/s13024-018-0286-0 – volume: 128 start-page: 381 year: 2014 ident: B42 article-title: Brain pericytes acquire a microglial phenotype after stroke. publication-title: Acta Neuropathol. doi: 10.1007/s00401-014-1295-x – volume: 12 start-page: 451 year: 2019 ident: B17 article-title: Induction of mesoderm and neural crest-derived pericytes from human pluripotent stem cells to study blood-brain barrier interactions. publication-title: Stem Cell Rep. doi: 10.1016/j.stemcr.2019.01.005 – volume: 443 start-page: 700 year: 2006 ident: B43 article-title: Bidirectional control of CNS capillary diameter by pericytes. publication-title: Nature doi: 10.1038/nature05193 – volume: 87 start-page: 95 year: 2015 ident: B26 article-title: Regional blood flow in the normal and ischemic brain is controlled by arteriolar smooth muscle cell contractility and not by capillary pericytes. publication-title: Neuron doi: 10.1016/j.neuron.2015.06.001 – volume: 71 start-page: 212 year: 2006 ident: B28 article-title: Measurement of RBC deformation and velocity in capillaries in vivo. publication-title: Microvasc. Res. doi: 10.1016/j.mvr.2006.02.006 – volume: 7 start-page: 452 year: 2005 ident: B10 article-title: The role of pericytes in blood-vessel formation, and. maintenance. publication-title: Neuro Oncol. doi: 10.1215/s1152851705000232 – volume: 180 start-page: 117 year: 2018 ident: B13 article-title: 3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes. publication-title: Biomaterials doi: 10.1016/j.biomaterials.2018.07.014 – volume: 171 start-page: 1989 year: 2007 ident: B59 article-title: Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells. publication-title: Am. J. Pathol. doi: 10.2353/ajpath.2007.070050 – volume: 115 start-page: E5796 year: 2018 ident: B12 article-title: Stimulation-induced increases in cerebral blood flow and local capillary vasoconstriction depend on conducted vascular responses. publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.1707702115 – volume: 68 start-page: 29 year: 1923 ident: B63 article-title: Der feinere bau der blutcapillaren. publication-title: Z. Anat. Entwicklungsgesch. doi: 10.1007/bf02593544 – volume: 63 start-page: 287 year: 2009 ident: B31 article-title: The role of apolipoprotein E in Alzheimer’s disease. publication-title: Neuron doi: 10.1016/j.neuron.2009.06.026 – volume: 18 start-page: 419 ident: B32 article-title: Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease. publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn.2017.48 – volume: 527 start-page: 780 year: 2019 ident: B18 article-title: Neural microvascular pericytes contribute to human adult neurogenesis. publication-title: J. Comp. Neurol. doi: 10.1002/cne.24565 – volume: 508 start-page: 55 year: 2014 ident: B21 article-title: Capillary pericytes regulate cerebral blood flow in health and disease. publication-title: Nature doi: 10.1038/nature13165 – volume: 37 start-page: 2013 year: 2017 ident: B41 article-title: Novel method to study pericyte contractility and responses to ischaemia in vitrousing electrical impedance. publication-title: J. Cereb. Blood Flow Metab. doi: 10.1177/0271678X16659495 – volume: 145 start-page: 66 year: 2010 ident: B34 article-title: Combined targeting of perivascular and endothelial tumor cells enhances anti-tumor efficacy of liposomal chemotherapy in neuroblastoma. publication-title: J. Control Release doi: 10.1016/j.jconrel.2010.03.015 – volume: 23 start-page: 303 year: 2013 ident: B50 article-title: Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer’s disease. publication-title: Brain Pathol. doi: 10.1111/bpa.12004 – volume: 15 start-page: 1031 year: 2009 ident: B62 article-title: Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery. publication-title: Nat. Med. doi: 10.1038/nm.2022 – volume: 86 start-page: 53 year: 2016 ident: B6 article-title: Discovering cardiac pericyte biology: from physiopathological mechanisms to potential therapeutic applications in ischemic heart disease. publication-title: Vascul. Pharmacol. doi: 10.1016/j.vph.2016.05.009 – volume: 39 start-page: 411 year: 2019 ident: B19 article-title: Organizational hierarchy and structural diversity of microvascular pericytes in adult mouse cortex. publication-title: J. Cereb. Blood Flow Metab. doi: 10.1177/0271678X17732229 – volume: 143 start-page: 225 year: 2015 ident: B45 article-title: Use of labeled tomato lectin for imaging vasculature structures. publication-title: Histochem. Cell Biol. doi: 10.1007/s00418-014-1301-3 – volume: 203 start-page: 1519 year: 2006 ident: B58 article-title: Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils. publication-title: J. Exp. Med. doi: 10.1084/jem.20051210 – volume: 55 start-page: 261 year: 2011 ident: B44 article-title: The role of pericytes in angiogenesis. publication-title: Int. J. Dev. Biol. doi: 10.1387/ijdb.103167dr – volume: 121 start-page: 5192 year: 2013 ident: B46 article-title: Imatinib disrupts lymphoma angiogenesis by targeting vascular pericytes. publication-title: Blood doi: 10.1182/blood-2013-03-490763 – volume: 99 start-page: 21 year: 2019 ident: B54 article-title: Blood-brain barrier: from physiology to disease and back. publication-title: Physiol. Rev. doi: 10.1152/physrev.00050.2017 – volume: 11 start-page: 2397 year: 2016 ident: B30 article-title: Pericyte-targeting drug delivery and tissue engineering. publication-title: Int. J. Nanomed. doi: 10.2147/IJN.S105274 – volume: 11 start-page: 169 year: 2015 ident: B37 article-title: Pericytes: a double-edged sword in cancer therapy. publication-title: Future Oncol. doi: 10.2217/fon.14.123 – volume: 5 year: 2019 ident: B52 article-title: Human pluripotent stem cell-derived brain pericyte-like cells induce blood-brain barrier properties. publication-title: Sci. Adv. doi: 10.1126/sciadv.aau7375 – volume: 33 start-page: 1962 year: 2015 ident: B39 article-title: Brain vascular pericytes following ischemia have multipotential stem cell activity to differentiate into neural and vascular lineage cells. publication-title: Stem Cells doi: 10.1002/stem.1977 – volume: 51 start-page: 363 year: 2000 ident: B47 article-title: Cellular mechanisms of CNS pericytes. publication-title: Brain Res. Bull. doi: 10.1016/s0361-9230(99)00260-9 – volume: 24 start-page: 371 year: 2014 ident: B60 article-title: The pericyte: a forgotten cell type with important implications for Alzheimer’s disease? publication-title: Brain Pathol. doi: 10.1111/bpa.12152 – volume: 37 start-page: 129 year: 2017 ident: B56 article-title: Pericytes as inducers of rapid, matrix metalloproteinase-9-dependent capillary damage during ischemia. publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2891-16.2016 – volume: 19 start-page: 1619 year: 2016 ident: B38 article-title: Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles. publication-title: Nat. Rev. Neurosci. doi: 10.1038/nn.4428 – volume: 11 year: 2016 ident: B25 article-title: Distinct contributions of astrocytes and pericytes to neuroinflammation identified in a 3D human blood-brain barrier on a chip. publication-title: PLoS One doi: 10.1371/journal.pone.0150360 – volume: 20 start-page: 1023 year: 2017 ident: B15 article-title: A fluoro-Nissl dye identifies pericytes as distinct vascular mural cells during in vivo brain imaging. publication-title: Nat. Rev. Neurosci. doi: 10.1038/nn.4564 – volume: 468 start-page: 557 year: 2010 ident: B3 article-title: Pericytes regulate the blood-brain barrier. publication-title: Nature doi: 10.1038/nature09522 – volume: 68 start-page: 409 year: 2010 ident: B8 article-title: Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. publication-title: Neuron doi: 10.1016/j.neuron.2010.09.043 – volume: 38 start-page: 291 year: 2017 ident: B48 article-title: Brain pericytes as mediators of neuroinflammation. publication-title: Trends Pharmacol. Sci. doi: 10.1016/j.tips.2016.12.001 – volume: 6 start-page: 1 year: 2012 ident: B7 article-title: Pericytes on the tumor vasculature: jekyll or hyde? publication-title: Cancer Microenviron. doi: 10.1007/s12307-012-0102-2 – volume: 485 start-page: 512 year: 2012 ident: B9 article-title: Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. publication-title: Nature doi: 10.1038/nature11087 – volume: 21 start-page: 193 year: 2011 ident: B2 article-title: Pericytes: developmental, physiological and. pathological perspectives, problems, and promises. publication-title: Dev. Cell doi: 10.1016/j.devcel.2011.07.001 – volume: 5 start-page: 3060 year: 2014 ident: B20 article-title: Selective eradication of tumor vascular pericytes by peptide-conjugated nanoparticles for antiangiogenic therapy of melanoma lung metastasis. publication-title: Biomaterials doi: 10.1016/j.biomaterials.2013.12.027 – volume: 2 year: 2015 ident: B23 article-title: Pericyte structure and distribution in the cerebral cortex revealed by high-resolution imaging of transgenic mice. publication-title: Neurophoton doi: 10.1117/1.NPh.2.4.041402 – volume: 11 year: 2014 ident: B27 article-title: A role for human brain pericytes in neuroinflammation. publication-title: J. Neuroinflamm. doi: 10.1186/1742-2094-11-104 – volume: 468 start-page: 232 year: 2010 ident: B4 article-title: Glial and. neuronal control of brain blood flow. publication-title: Nature doi: 10.1038/nature09613 – volume: 4 year: 2013 ident: B49 article-title: Pericyte loss influences Alzheimer-like neurodegeneration in mice. publication-title: Nat. Commun. doi: 10.1038/ncomms3932 – volume: 153 start-page: 543 year: 2001 ident: B24 article-title: Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. publication-title: J. Cell Biol. doi: 10.1083/jcb.153.3.543 – volume: 2 year: 2010 ident: B22 article-title: Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease. publication-title: Front. Neuroenergetics doi: 10.3389/fnene.2010.00005 – volume: 36 start-page: 451 year: 2016 ident: B5 article-title: What is a pericyte? publication-title: J. Cereb. Blood Flow Metab. doi: 10.1177/0271678X15610340 – volume: 38 start-page: 456 year: 2017 ident: B29 article-title: Visualization of vascular mural cells in developing brain using genetically labeled transgenic reporter mice. publication-title: J. Cereb. Blood Flow Metab. doi: 10.1177/0271678X17697720 – volume: 10 year: 2018 ident: B11 article-title: Pericyte structural remodeling in cerebrovascular health and homeostasis. publication-title: Front. Aging Neurosci. doi: 10.3389/fnagi.2018.00210 – volume: 14 start-page: 1 year: 2018 ident: B57 article-title: A molecular atlas of cell types and zonation in the brain vasculature. publication-title: Nature |
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| SubjectTerms | Angiogenesis Blood flow Blood vessels Blood-brain barrier brain Brain research Capillaries Cell cycle Cerebral blood flow Functional anatomy Growth factors Inflammation Neurodegenerative diseases neurological disease Neuroscience neurovascular Pericytes Proteins Roles Smooth muscle Stem cells Vascular diseases |
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| Title | Pericytes and Neurovascular Function in the Healthy and Diseased Brain |
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