COVID-19 Induced Acute Respiratory Distress Syndrome—A Multicenter Observational Study
Background: Proportions of patients dying from the coronavirus disease-19 (COVID-19) vary between different countries. We report the characteristics; clinical course and outcome of patients requiring intensive care due to COVID-19 induced acute respiratory distress syndrome (ARDS). Methods: This is...
Uložené v:
| Vydané v: | Frontiers in medicine Ročník 7; s. 599533 |
|---|---|
| Hlavní autori: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
Switzerland
Frontiers Media SA
18.12.2020
Frontiers Media S.A |
| Predmet: | |
| ISSN: | 2296-858X, 2296-858X |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | Background:
Proportions of patients dying from the coronavirus disease-19 (COVID-19) vary between different countries. We report the characteristics; clinical course and outcome of patients requiring intensive care due to COVID-19 induced acute respiratory distress syndrome (ARDS).
Methods:
This is a retrospective, observational multicentre study in five German secondary or tertiary care hospitals. All patients consecutively admitted to the intensive care unit (ICU) in any of the participating hospitals between March 12 and May 4, 2020 with a COVID-19 induced ARDS were included.
Results:
A total of 106 ICU patients were treated for COVID-19 induced ARDS, whereas severe ARDS was present in the majority of cases. Survival of ICU treatment was 65.0%. Median duration of ICU treatment was 11 days; median duration of mechanical ventilation was 9 days. The majority of ICU treated patients (75.5%) did not receive any antiviral or anti-inflammatory therapies. Venovenous (vv) ECMO was utilized in 16.3%. ICU triage with population-level decision making was not necessary at any time. Univariate analysis associated older age, diabetes mellitus or a higher SOFA score on admission with non-survival during ICU stay.
Conclusions:
A high level of care adhering to standard ARDS treatments lead to a good outcome in critically ill COVID-19 patients. |
|---|---|
| AbstractList | Background: Proportions of patients dying from the coronavirus disease-19 (COVID-19) vary between different countries. We report the characteristics; clinical course and outcome of patients requiring intensive care due to COVID-19 induced acute respiratory distress syndrome (ARDS).Methods: This is a retrospective, observational multicentre study in five German secondary or tertiary care hospitals. All patients consecutively admitted to the intensive care unit (ICU) in any of the participating hospitals between March 12 and May 4, 2020 with a COVID-19 induced ARDS were included.Results: A total of 106 ICU patients were treated for COVID-19 induced ARDS, whereas severe ARDS was present in the majority of cases. Survival of ICU treatment was 65.0%. Median duration of ICU treatment was 11 days; median duration of mechanical ventilation was 9 days. The majority of ICU treated patients (75.5%) did not receive any antiviral or anti-inflammatory therapies. Venovenous (vv) ECMO was utilized in 16.3%. ICU triage with population-level decision making was not necessary at any time. Univariate analysis associated older age, diabetes mellitus or a higher SOFA score on admission with non-survival during ICU stay.Conclusions: A high level of care adhering to standard ARDS treatments lead to a good outcome in critically ill COVID-19 patients. Background: Proportions of patients dying from the coronavirus disease-19 (COVID-19) vary between different countries. We report the characteristics; clinical course and outcome of patients requiring intensive care due to COVID-19 induced acute respiratory distress syndrome (ARDS). Methods: This is a retrospective, observational multicentre study in five German secondary or tertiary care hospitals. All patients consecutively admitted to the intensive care unit (ICU) in any of the participating hospitals between March 12 and May 4, 2020 with a COVID-19 induced ARDS were included. Results: A total of 106 ICU patients were treated for COVID-19 induced ARDS, whereas severe ARDS was present in the majority of cases. Survival of ICU treatment was 65.0%. Median duration of ICU treatment was 11 days; median duration of mechanical ventilation was 9 days. The majority of ICU treated patients (75.5%) did not receive any antiviral or anti-inflammatory therapies. Venovenous (vv) ECMO was utilized in 16.3%. ICU triage with population-level decision making was not necessary at any time. Univariate analysis associated older age, diabetes mellitus or a higher SOFA score on admission with non-survival during ICU stay. Conclusions: A high level of care adhering to standard ARDS treatments lead to a good outcome in critically ill COVID-19 patients. Background: Proportions of patients dying from the coronavirus disease-19 (COVID-19) vary between different countries. We report the characteristics; clinical course and outcome of patients requiring intensive care due to COVID-19 induced acute respiratory distress syndrome (ARDS). Methods: This is a retrospective, observational multicentre study in five German secondary or tertiary care hospitals. All patients consecutively admitted to the intensive care unit (ICU) in any of the participating hospitals between March 12 and May 4, 2020 with a COVID-19 induced ARDS were included. Results: A total of 106 ICU patients were treated for COVID-19 induced ARDS, whereas severe ARDS was present in the majority of cases. Survival of ICU treatment was 65.0%. Median duration of ICU treatment was 11 days; median duration of mechanical ventilation was 9 days. The majority of ICU treated patients (75.5%) did not receive any antiviral or anti-inflammatory therapies. Venovenous (vv) ECMO was utilized in 16.3%. ICU triage with population-level decision making was not necessary at any time. Univariate analysis associated older age, diabetes mellitus or a higher SOFA score on admission with non-survival during ICU stay. Conclusions: A high level of care adhering to standard ARDS treatments lead to a good outcome in critically ill COVID-19 patients.Background: Proportions of patients dying from the coronavirus disease-19 (COVID-19) vary between different countries. We report the characteristics; clinical course and outcome of patients requiring intensive care due to COVID-19 induced acute respiratory distress syndrome (ARDS). Methods: This is a retrospective, observational multicentre study in five German secondary or tertiary care hospitals. All patients consecutively admitted to the intensive care unit (ICU) in any of the participating hospitals between March 12 and May 4, 2020 with a COVID-19 induced ARDS were included. Results: A total of 106 ICU patients were treated for COVID-19 induced ARDS, whereas severe ARDS was present in the majority of cases. Survival of ICU treatment was 65.0%. Median duration of ICU treatment was 11 days; median duration of mechanical ventilation was 9 days. The majority of ICU treated patients (75.5%) did not receive any antiviral or anti-inflammatory therapies. Venovenous (vv) ECMO was utilized in 16.3%. ICU triage with population-level decision making was not necessary at any time. Univariate analysis associated older age, diabetes mellitus or a higher SOFA score on admission with non-survival during ICU stay. Conclusions: A high level of care adhering to standard ARDS treatments lead to a good outcome in critically ill COVID-19 patients. Proportions of patients dying from the coronavirus disease-19 (COVID-19) vary between different countries. We report the characteristics; clinical course and outcome of patients requiring intensive care due to COVID-19 induced acute respiratory distress syndrome (ARDS). This is a retrospective, observational multicentre study in five German secondary or tertiary care hospitals. All patients consecutively admitted to the intensive care unit (ICU) in any of the participating hospitals between March 12 and May 4, 2020 with a COVID-19 induced ARDS were included. A total of 106 ICU patients were treated for COVID-19 induced ARDS, whereas severe ARDS was present in the majority of cases. Survival of ICU treatment was 65.0%. Median duration of ICU treatment was 11 days; median duration of mechanical ventilation was 9 days. The majority of ICU treated patients (75.5%) did not receive any antiviral or anti-inflammatory therapies. Venovenous (vv) ECMO was utilized in 16.3%. ICU triage with population-level decision making was not necessary at any time. Univariate analysis associated older age, diabetes mellitus or a higher SOFA score on admission with non-survival during ICU stay. A high level of care adhering to standard ARDS treatments lead to a good outcome in critically ill COVID-19 patients. |
| Author | Kranke, Peter Frantz, Stefan Steinfeldt, Thorsten Reyher, Christian Mutlak, Haitham Kredel, Markus Adam, Elisabeth Hannah Rolfes, Caroline Herrmann, Johannes Gill-Schuster, Daniel Zausig, York Ertl, Georg Zacharowski, Kai Klinker, Hartwig Muellenbach, Ralf Michael Torje, Iuliu Sonntagbauer, Michael Brack, Alexander Meybohm, Patrick Lotz, Christopher Wurmb, Thomas Sanns, Andreas Notz, Quirin Stumpner, Jan Heuschmann, Peter Rücker, Viktoria Helmer, Philipp Ungemach-Papenberg, Peter Schmid, Benedikt Schlesinger, Tobias Weismann, Dirk |
| AuthorAffiliation | 3 Department of Anesthesiology and Critical Care, Klinikum Aschaffenburg-Alzenau , Aschaffenburg , Germany 10 Clinical Trial Center, University Hospital Würzburg, Julius-Maximilians-University , Würzburg , Germany 6 Department of Anesthesiology and Critical Care, Sana-Klinikum Offenbach GmbH , Offenbach , Germany 9 Institute for Clinical Epidemiology and Biometry, Julius-Maximilians-University , Würzburg , Germany 7 Department of Internal Medicine I, University Hospital Würzburg , Würzburg , Germany 2 Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University , Frankfurt , Germany 4 Department of Anesthesiology and Critical Care, Diakoneo Diak Klinikum Schwabisch Hall , Schwabisch-Hall , Germany 5 Department of Critical Care, Emergency Medicine and Anesthesiology, ARDS/ECMO-Centre, Campus Kassel of the University of Southampton , Southampton , Germany 1 Department of Anesthesiology and Critical Care, University Hospital Würzburg, Ju |
| AuthorAffiliation_xml | – name: 1 Department of Anesthesiology and Critical Care, University Hospital Würzburg, Julius-Maximilians-University Würzburg , Würzburg , Germany – name: 6 Department of Anesthesiology and Critical Care, Sana-Klinikum Offenbach GmbH , Offenbach , Germany – name: 3 Department of Anesthesiology and Critical Care, Klinikum Aschaffenburg-Alzenau , Aschaffenburg , Germany – name: 4 Department of Anesthesiology and Critical Care, Diakoneo Diak Klinikum Schwabisch Hall , Schwabisch-Hall , Germany – name: 8 Department of Internal Medicine II, University Hospital Würzburg , Würzburg , Germany – name: 2 Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University , Frankfurt , Germany – name: 7 Department of Internal Medicine I, University Hospital Würzburg , Würzburg , Germany – name: 9 Institute for Clinical Epidemiology and Biometry, Julius-Maximilians-University , Würzburg , Germany – name: 10 Clinical Trial Center, University Hospital Würzburg, Julius-Maximilians-University , Würzburg , Germany – name: 5 Department of Critical Care, Emergency Medicine and Anesthesiology, ARDS/ECMO-Centre, Campus Kassel of the University of Southampton , Southampton , Germany |
| Author_xml | – sequence: 1 givenname: Johannes surname: Herrmann fullname: Herrmann, Johannes – sequence: 2 givenname: Elisabeth Hannah surname: Adam fullname: Adam, Elisabeth Hannah – sequence: 3 givenname: Quirin surname: Notz fullname: Notz, Quirin – sequence: 4 givenname: Philipp surname: Helmer fullname: Helmer, Philipp – sequence: 5 givenname: Michael surname: Sonntagbauer fullname: Sonntagbauer, Michael – sequence: 6 givenname: Peter surname: Ungemach-Papenberg fullname: Ungemach-Papenberg, Peter – sequence: 7 givenname: Andreas surname: Sanns fullname: Sanns, Andreas – sequence: 8 givenname: York surname: Zausig fullname: Zausig, York – sequence: 9 givenname: Thorsten surname: Steinfeldt fullname: Steinfeldt, Thorsten – sequence: 10 givenname: Iuliu surname: Torje fullname: Torje, Iuliu – sequence: 11 givenname: Benedikt surname: Schmid fullname: Schmid, Benedikt – sequence: 12 givenname: Tobias surname: Schlesinger fullname: Schlesinger, Tobias – sequence: 13 givenname: Caroline surname: Rolfes fullname: Rolfes, Caroline – sequence: 14 givenname: Christian surname: Reyher fullname: Reyher, Christian – sequence: 15 givenname: Markus surname: Kredel fullname: Kredel, Markus – sequence: 16 givenname: Jan surname: Stumpner fullname: Stumpner, Jan – sequence: 17 givenname: Alexander surname: Brack fullname: Brack, Alexander – sequence: 18 givenname: Thomas surname: Wurmb fullname: Wurmb, Thomas – sequence: 19 givenname: Daniel surname: Gill-Schuster fullname: Gill-Schuster, Daniel – sequence: 20 givenname: Peter surname: Kranke fullname: Kranke, Peter – sequence: 21 givenname: Dirk surname: Weismann fullname: Weismann, Dirk – sequence: 22 givenname: Hartwig surname: Klinker fullname: Klinker, Hartwig – sequence: 23 givenname: Peter surname: Heuschmann fullname: Heuschmann, Peter – sequence: 24 givenname: Viktoria surname: Rücker fullname: Rücker, Viktoria – sequence: 25 givenname: Stefan surname: Frantz fullname: Frantz, Stefan – sequence: 26 givenname: Georg surname: Ertl fullname: Ertl, Georg – sequence: 27 givenname: Ralf Michael surname: Muellenbach fullname: Muellenbach, Ralf Michael – sequence: 28 givenname: Haitham surname: Mutlak fullname: Mutlak, Haitham – sequence: 29 givenname: Patrick surname: Meybohm fullname: Meybohm, Patrick – sequence: 30 givenname: Kai surname: Zacharowski fullname: Zacharowski, Kai – sequence: 31 givenname: Christopher surname: Lotz fullname: Lotz, Christopher |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33392222$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1ks1uEzEUhS1URH_onhUaiQ2bCR5fe8beIEUphUhFkSig7iyP56Y4moyD7amUHQ_BE_IkOE2L2kp4Y8s-99O51-eYHAx-QEJeVXQCINW75Rq7CaOMToRSAuAZOWJM1aUU8urgwfmQnMa4opRWwASv4AU5BADF8joiV7PF9_lZWaliPnSjxa6Y2jFh8QXjxgWTfNgWZy6mgDEWl9uhC36Nf379nhafxz45i0PCUCzaiOHGJOcH0xeXaey2L8nzpekjnt7tJ-Tb-Yevs0_lxeLjfDa9KC1XNJWgGgutsKzm1nKeDaqKiraWneWy7igVUlYojJVGVp1AaAwCp8ChZXUtKZyQ-Z7bebPSm-DWJmy1N07fXvhwrU3IRnvUDWVohW1aDhVnsjaUKSYRhGFGtNxk1vs9azO2ebi75oLpH0Efvwzuh772N7ppGgFSZMDbO0DwP0eMSa9dtNj3ZkA_Rs14I6gSvFFZ-uaJdOXHkMcXNbAGcoeU1ln1-qGjf1buPzAL6r3ABh9jwKW2Lt1-RDboel1RvQuL3oVF78Ki92HJhfRJ4T37vyV_AWJewP8 |
| CitedBy_id | crossref_primary_10_3390_biomedicines12020439 crossref_primary_10_1002_pro_4451 crossref_primary_10_3892_etm_2021_10731 crossref_primary_10_1002_14651858_CD015017_pub3 crossref_primary_10_3390_v15061324 crossref_primary_10_1186_s12931_024_02893_0 crossref_primary_10_1186_s13063_024_08155_0 crossref_primary_10_1038_s41598_022_18179_8 crossref_primary_10_3390_diagnostics12092072 crossref_primary_10_1136_bmjopen_2022_066626 crossref_primary_10_3390_jcm12041252 crossref_primary_10_1186_s12890_023_02664_5 crossref_primary_10_3389_fmed_2021_772056 |
| Cites_doi | 10.1001/jama.2020.4326 10.1056/NEJMc2022236 10.1016/S0140-6736(20)30183-5 10.1136/thoraxjnl-2017-211280 10.1016/S2213-2600(20)30079-5 10.1001/jama.2020.5394 10.1016/S2213-2600(20)30316-7 10.1016/S0140-6736(20)30566-3 10.1056/NEJMoa2021436 10.1159/000502157 10.1001/jamainternmed.2020.0994 10.1055/s-0042-100484 10.1001/jama.289.18.2363 10.1001/jama.2016.0291 10.1097/SHK.0000000000000234 10.1001/jama.2020.1585 10.1182/blood-2014-05-552729 10.1001/jama.2012.5669 10.1164/rccm.202003-0817LE 10.1001/jamainternmed.2020.3539 10.1016/S0140-6736(20)31189-2 10.1056/NEJMoa2004500 |
| ContentType | Journal Article |
| Copyright | Copyright © 2020 Herrmann, Adam, Notz, Helmer, Sonntagbauer, Ungemach-Papenberg, Sanns, Zausig, Steinfeldt, Torje, Schmid, Schlesinger, Rolfes, Reyher, Kredel, Stumpner, Brack, Wurmb, Gill-Schuster, Kranke, Weismann, Klinker, Heuschmann, Rücker, Frantz, Ertl, Muellenbach, Mutlak, Meybohm, Zacharowski and Lotz. 2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2020 Herrmann, Adam, Notz, Helmer, Sonntagbauer, Ungemach-Papenberg, Sanns, Zausig, Steinfeldt, Torje, Schmid, Schlesinger, Rolfes, Reyher, Kredel, Stumpner, Brack, Wurmb, Gill-Schuster, Kranke, Weismann, Klinker, Heuschmann, Rücker, Frantz, Ertl, Muellenbach, Mutlak, Meybohm, Zacharowski and Lotz. 2020 Herrmann, Adam, Notz, Helmer, Sonntagbauer, Ungemach-Papenberg, Sanns, Zausig, Steinfeldt, Torje, Schmid, Schlesinger, Rolfes, Reyher, Kredel, Stumpner, Brack, Wurmb, Gill-Schuster, Kranke, Weismann, Klinker, Heuschmann, Rücker, Frantz, Ertl, Muellenbach, Mutlak, Meybohm, Zacharowski and Lotz |
| Copyright_xml | – notice: Copyright © 2020 Herrmann, Adam, Notz, Helmer, Sonntagbauer, Ungemach-Papenberg, Sanns, Zausig, Steinfeldt, Torje, Schmid, Schlesinger, Rolfes, Reyher, Kredel, Stumpner, Brack, Wurmb, Gill-Schuster, Kranke, Weismann, Klinker, Heuschmann, Rücker, Frantz, Ertl, Muellenbach, Mutlak, Meybohm, Zacharowski and Lotz. – notice: 2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Copyright © 2020 Herrmann, Adam, Notz, Helmer, Sonntagbauer, Ungemach-Papenberg, Sanns, Zausig, Steinfeldt, Torje, Schmid, Schlesinger, Rolfes, Reyher, Kredel, Stumpner, Brack, Wurmb, Gill-Schuster, Kranke, Weismann, Klinker, Heuschmann, Rücker, Frantz, Ertl, Muellenbach, Mutlak, Meybohm, Zacharowski and Lotz. 2020 Herrmann, Adam, Notz, Helmer, Sonntagbauer, Ungemach-Papenberg, Sanns, Zausig, Steinfeldt, Torje, Schmid, Schlesinger, Rolfes, Reyher, Kredel, Stumpner, Brack, Wurmb, Gill-Schuster, Kranke, Weismann, Klinker, Heuschmann, Rücker, Frantz, Ertl, Muellenbach, Mutlak, Meybohm, Zacharowski and Lotz |
| DBID | AAYXX CITATION NPM 3V. 7X7 7XB 88E 8C1 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU COVID DWQXO FYUFA GHDGH K9. M0S M1P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 5PM DOA |
| DOI | 10.3389/fmed.2020.599533 |
| DatabaseName | CrossRef PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Public Health Database Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials - QC ProQuest Central ProQuest One Community College Coronavirus Research Database ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection Medical Database ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Public Health ProQuest One Academic Eastern Edition Coronavirus Research Database ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | CrossRef MEDLINE - Academic PubMed Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: ProQuest Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2296-858X |
| ExternalDocumentID | oai_doaj_org_article_702ec5c7b4314286a02928e35a2a5b4a PMC7775385 33392222 10_3389_fmed_2020_599533 |
| Genre | Journal Article |
| GeographicLocations | United States--US Italy Germany |
| GeographicLocations_xml | – name: United States--US – name: Germany – name: Italy |
| GroupedDBID | 53G 5VS 9T4 AAFWJ AAYXX ACGFS ADBBV ADRAZ AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK GROUPED_DOAJ HYE KQ8 M48 M~E OK1 PGMZT RPM ACXDI IAO IEA IHR IHW IPNFZ ISR NPM RIG 3V. 7X7 7XB 88E 8C1 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU COVID DWQXO FYUFA K9. M1P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 5PM |
| ID | FETCH-LOGICAL-c490t-397c3b5c264cc442549105b68dc486d005881e5ac8a81d5e37ae340343b266803 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 15 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000603968300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2296-858X |
| IngestDate | Fri Oct 03 12:41:35 EDT 2025 Tue Sep 30 14:52:46 EDT 2025 Sun Nov 09 13:04:59 EST 2025 Tue Nov 25 15:41:07 EST 2025 Thu Jan 02 22:58:12 EST 2025 Sat Nov 29 04:29:14 EST 2025 Tue Nov 18 19:48:59 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | COVID-19 pandemia ARDS (acute respiratory distress syndrome) intensive care medicine Germany |
| Language | English |
| License | Copyright © 2020 Herrmann, Adam, Notz, Helmer, Sonntagbauer, Ungemach-Papenberg, Sanns, Zausig, Steinfeldt, Torje, Schmid, Schlesinger, Rolfes, Reyher, Kredel, Stumpner, Brack, Wurmb, Gill-Schuster, Kranke, Weismann, Klinker, Heuschmann, Rücker, Frantz, Ertl, Muellenbach, Mutlak, Meybohm, Zacharowski and Lotz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c490t-397c3b5c264cc442549105b68dc486d005881e5ac8a81d5e37ae340343b266803 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 These authors share senior authorship Reviewed by: Jesus Rico-Feijoo, Hospital Universitario Río Hortega, Spain; Tommaso Tonetti, University of Bologna, Italy Edited by: Jiapeng Huang, University of Louisville, United States This article was submitted to Intensive Care Medicine and Anesthesiology, a section of the journal Frontiers in Medicine These authors share first authorship |
| OpenAccessLink | https://doaj.org/article/702ec5c7b4314286a02928e35a2a5b4a |
| PMID | 33392222 |
| PQID | 3273034006 |
| PQPubID | 7426803 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_702ec5c7b4314286a02928e35a2a5b4a pubmedcentral_primary_oai_pubmedcentral_nih_gov_7775385 proquest_miscellaneous_2475095479 proquest_journals_3273034006 pubmed_primary_33392222 crossref_citationtrail_10_3389_fmed_2020_599533 crossref_primary_10_3389_fmed_2020_599533 |
| PublicationCentury | 2000 |
| PublicationDate | 2020-12-18 |
| PublicationDateYYYYMMDD | 2020-12-18 |
| PublicationDate_xml | – month: 12 year: 2020 text: 2020-12-18 day: 18 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland – name: Lausanne |
| PublicationTitle | Frontiers in medicine |
| PublicationTitleAlternate | Front Med (Lausanne) |
| PublicationYear | 2020 |
| Publisher | Frontiers Media SA Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Media SA – name: Frontiers Media S.A |
| References | Arentz (B14) 2020; 323 Cummings (B15) 2020; 395 Group (B23) 2020 Fichtner (B24) 2019; 98 Warren (B6) 2018; 73 Yang (B11) 2020; 8 Drewry (B21) 2014; 42 Force (B7) 2012; 307 Wolf-Maier (B20) 2003; 289 Gattinoni (B3) 2020; 201 Grasselli (B26) 2020; 323 (B17) 2020 Lee (B22) 2014; 124 Haas (B5) 2016; 141 Wang (B10) 2020; 33 Karagiannidis (B18) 2020; 8 B1 B2 B4 Wu (B19) 2020; 180 Bellani (B8) 2016; 315 Bhatraju (B13) 2020; 382 Grasselli (B16) 2020; 180 Beigel (B25) 2020; 383 Zhou (B12) 2020; 395 Huang (B9) 2020; 395 |
| References_xml | – volume: 323 start-page: 1612 year: 2020 ident: B14 article-title: Characteristics and outcomes of 21 critically ill patients with COVID-19 in Washington State publication-title: JAMA. doi: 10.1001/jama.2020.4326 – volume: 383 start-page: 1813 year: 2020 ident: B25 article-title: Remdesivir for the treatment of Covid-19—preliminary report publication-title: N Engl J Med doi: 10.1056/NEJMc2022236 – volume: 395 start-page: 497 year: 2020 ident: B9 article-title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China publication-title: Lancet. doi: 10.1016/S0140-6736(20)30183-5 – ident: B1 – volume: 73 start-page: 840 year: 2018 ident: B6 article-title: Severity scoring of lung oedema on the chest radiograph is associated with clinical outcomes in ARDS publication-title: Thorax. doi: 10.1136/thoraxjnl-2017-211280 – volume: 8 start-page: 475 year: 2020 ident: B11 article-title: Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study publication-title: Lancet Respir Med. doi: 10.1016/S2213-2600(20)30079-5 – volume: 323 start-page: 1574 year: 2020 ident: B26 article-title: Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy publication-title: JAMA. doi: 10.1001/jama.2020.5394 – volume: 8 start-page: 853 year: 2020 ident: B18 article-title: Case characteristics, resource use, and outcomes of 10 021 patients with COVID-19 admitted to 920 German hospitals: an observational study publication-title: Lancet Respir Med doi: 10.1016/S2213-2600(20)30316-7 – volume: 395 start-page: 1054 year: 2020 ident: B12 article-title: Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study publication-title: Lancet. doi: 10.1016/S0140-6736(20)30566-3 – year: 2020 ident: B23 article-title: Dexamethasone in hospitalized patients with covid-19—preliminary report publication-title: N Engl J Med doi: 10.1056/NEJMoa2021436 – volume: 98 start-page: 357 year: 2019 ident: B24 article-title: Clinical guideline for treating acute respiratory insufficiency with invasive ventilation and extracorporeal membrane oxygenation: evidence-based recommendations for choosing modes and setting parameters of mechanical ventilation publication-title: Respiration. doi: 10.1159/000502157 – volume: 180 start-page: 934 year: 2020 ident: B19 article-title: Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China publication-title: JAMA Intern Med doi: 10.1001/jamainternmed.2020.0994 – ident: B2 – volume: 141 start-page: 453 year: 2016 ident: B5 article-title: [German S3 practice guidelines on prevention of venous thromboembolism–New and established evidence] publication-title: Dtsch Med Wochenschr. doi: 10.1055/s-0042-100484 – volume: 289 start-page: 2363 year: 2003 ident: B20 article-title: Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States publication-title: JAMA. doi: 10.1001/jama.289.18.2363 – ident: B4 – volume: 315 start-page: 788 year: 2016 ident: B8 article-title: Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries publication-title: JAMA. doi: 10.1001/jama.2016.0291 – volume: 42 start-page: 383 year: 2014 ident: B21 article-title: Persistent lymphopenia after diagnosis of sepsis predicts mortality publication-title: Shock. doi: 10.1097/SHK.0000000000000234 – volume: 33 start-page: 1061 year: 2020 ident: B10 article-title: Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China publication-title: JAMA. doi: 10.1001/jama.2020.1585 – volume-title: ICNARC Report on COVID-19 in Critical Care May 22, 2020 year: 2020 ident: B17 – volume: 124 start-page: 188 year: 2014 ident: B22 article-title: Current concepts in the diagnosis and management of cytokine release syndrome publication-title: Blood. doi: 10.1182/blood-2014-05-552729 – volume: 307 start-page: 2526 year: 2012 ident: B7 article-title: Acute respiratory distress syndrome: the Berlin Definition publication-title: JAMA. doi: 10.1001/jama.2012.5669 – volume: 201 start-page: 1299 year: 2020 ident: B3 article-title: Covid-19 does not lead to a “typical” acute respiratory distress syndrome publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.202003-0817LE – volume: 180 start-page: 1345 year: 2020 ident: B16 article-title: Risk factors associated with mortality among patients with COVID-19 in intensive care units in Lombardy, Italy publication-title: JAMA Intern Med doi: 10.1001/jamainternmed.2020.3539 – volume: 395 start-page: 1763 year: 2020 ident: B15 article-title: Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study publication-title: Lancet doi: 10.1016/S0140-6736(20)31189-2 – volume: 382 start-page: 2012 year: 2020 ident: B13 article-title: COVID-19 in critically ill patients in the Seattle region—case series publication-title: N Engl J Med doi: 10.1056/NEJMoa2004500 |
| SSID | ssj0001325413 |
| Score | 2.2484078 |
| Snippet | Background:
Proportions of patients dying from the coronavirus disease-19 (COVID-19) vary between different countries. We report the characteristics; clinical... Proportions of patients dying from the coronavirus disease-19 (COVID-19) vary between different countries. We report the characteristics; clinical course and... Background: Proportions of patients dying from the coronavirus disease-19 (COVID-19) vary between different countries. We report the characteristics; clinical... |
| SourceID | doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 599533 |
| SubjectTerms | Age ARDS (acute respiratory distress syndrome) Body mass index Coronaviruses COVID-19 Diabetes Disease prevention Disease transmission Edema Fatalities Germany Hypertension Infections Intensive care intensive care medicine Medicine pandemia Patients Regression analysis Respiratory distress syndrome Severe acute respiratory syndrome Software Viruses |
| SummonAdditionalLinks | – databaseName: ProQuest Central dbid: BENPR link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3JjtQwEC1BD0Jc2JfAgILEhUOYxEtin1DPJpCgZzQs6psVLw0tofTQCxI3PoIv5EuoStxpGqG5kGPsKJU8L1Uu-z2AZ96TnINWmXQCA5TS2sxOfJGVYqId49oWoVUteVONRmo81qdxwW0Rt1Wux8R2oPYzR2vkexzn2Zxjiytfnn_NSDWKsqtRQuMy7BBTmRjAzv7R6PRss8rCMQAqeJefxGhMI1yBCEJZ_oKotjjfmo9a2v5_-Zp_b5n8Yw46vvG_1t-E69H7TIddc7kFl0JzG66-jfn1OzA-OPn4-jArdEqSHi74dOhWy5CebRLy6eG0O1-SvotkB79-_Bym7UFeMjvM0xPbL_Xiy2in4ve78OH46P3BqyxqL2RO6HyZoZviuJUO_SXnhKAwEj0xWyrvhCo9qREqhLF2qkaPVwZe1QG_jwtuccpXOb8Hg2bWhAeQkrq1qDFwk2EiKu4VHb8XZa6Z887rSQJ7awSMi8TkpI_xxWCAQpgZwswQZqbDLIHn_RPnHSnHBXX3CdS-HtFptzdm808m9k5T5Sw46SpLljFV1jnTTAUua1ZLK-oEdtewmtjHF2aDaQJP-2LsnZRyqZswWy0ME-SRSVHpBO53Lai3hHP0TfFKoNpqW1umbpc0088tA3hVYZSp5MOLzXoE1-hH0OabQu3CYDlfhcdwxX1bThfzJ7Gr_AY65h0a priority: 102 providerName: ProQuest |
| Title | COVID-19 Induced Acute Respiratory Distress Syndrome—A Multicenter Observational Study |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/33392222 https://www.proquest.com/docview/3273034006 https://www.proquest.com/docview/2475095479 https://pubmed.ncbi.nlm.nih.gov/PMC7775385 https://doaj.org/article/702ec5c7b4314286a02928e35a2a5b4a |
| Volume | 7 |
| WOSCitedRecordID | wos000603968300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2296-858X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001325413 issn: 2296-858X databaseCode: DOA dateStart: 20140101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2296-858X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001325413 issn: 2296-858X databaseCode: M~E dateStart: 20140101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2296-858X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001325413 issn: 2296-858X databaseCode: 7X7 dateStart: 20190101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central (subscription) customDbUrl: eissn: 2296-858X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001325413 issn: 2296-858X databaseCode: BENPR dateStart: 20190101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Publicly Available Content Database customDbUrl: eissn: 2296-858X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001325413 issn: 2296-858X databaseCode: PIMPY dateStart: 20190101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database (ProQuest) customDbUrl: eissn: 2296-858X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001325413 issn: 2296-858X databaseCode: 8C1 dateStart: 20190101 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwEB5BQagXxJtAWQWJC4fQJLZj-7jdtqIS3a7KQ8vJih8rVkJptQ8kbvwIfiG_hBknDbsIwYUcLCVOZHs8znzjxzcAL7yncA5aZcJxdFAqazM780VW8Zl2JdO2CDFqyRs5HqvpVE82Qn3RnrCWHrgV3L7My-CEkxYtHULlqs5LXarARF3WwvIIjRD1bDhTcXaFoeNTsHZdEr0wjd0UiBi0zF8RxRZjW3Yo0vX_CWP-vlVyw_Yc34HbHWhMh21l78K10NyDW6fdsvh9mI7OPpwcZoVOKRKHCz4duvUqpOe_1tHTw3l7LCR923EU_Pj2fZjG87dUalikZ7afocXCaIPh1wfw_vjo3eh11oVMyBzX-SpDdOGYFQ5hjnOck_eHAMpWyjuuKk9BBBVKv3aqRqAqApN1YDxnnFm01CpnD2GnuWjCY0gpKDWv0d8SYcYl84pOzfMq16XzzutZAvtXAjSu4xOnsBafDfoVJHJDIjckctOKPIGX_ReXLZfGX949oD7p3yMW7PgAdcN0umH-pRsJ7F31qOmG5tIwBGzYYPzbJPC8z8ZBRSsldRMu1ktTcgJSgkudwKNWAfqaMIaQEq8E5JZqbFV1O6eZf4rE3VKic6jEk__RtqewS-KinTWF2oOd1WIdnsFN92U1Xy4GcF1OZUwVpmpUDODGwdF4cj6I4wTvJienk48_AUiMEvo |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEB6VFFEuvAuGAkaCAwdTe3dt7x4QCg1VoyZpBAWF02KvNxAJOSUPUG_8CH4HP4pfwoxfIQj11gM-2mt7vPt5Hruz8wE8zjKic1DSC43AACVKUy8dZ4EXibEyjKs0sAVrSS8eDORopIYb8LPeC0NplbVOLBR1NjU0R77L0c76HBEXvTj54hFrFK2u1hQaJSwO7ek3DNnmz7sdHN8njO2_Ot478CpWAc8I5S88NMCGp6FBT8AYIShAQh8jjWRmhIwy4tmTKGBiZIK-XGh5nFh8Lxc8RWMmfY7PvQCbdKdsweaw2x--X83qcHxewMv1UIz-FMLDUkFS5j-j0l6cr9m_gibgX77t3ymaf9i8_av_W29dgyuVd-22y9_hOmzY_AZc6lf5AzdhtHf0rtvxAuUSZYmxmds2y4V1X68SDtzOpNw_476pijn8-v6j7RYblamb7Mw9SpupbHwZZWKe3oK35_Jd29DKp7m9Ay6xd4sEA9PQjkXMM0nlBUTkK2Yyk6mxA7v1iGtTFV4n_o_PGgMwwogmjGjCiC4x4sDT5o6TsujIGW1fEoiadlQuvDgxnX3UlfbRsc-sCU2ckmRMRonPFJOWhwlLwlQkDuzUMNKVDpvrFYYceNRcRu1DS0pJbqfLuWaCPM5QxMqB2yViG0k4R98bDwfiNSyvibp-JZ98KiqcxzFG0TK8e7ZYD2Hr4Ljf073u4PAeXKZOoUSjQO5AazFb2vtw0XxdTOazB9Vv6sKH88b6b95BdoA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=COVID-19+Induced+Acute+Respiratory+Distress+Syndrome-A+Multicenter+Observational+Study&rft.jtitle=Frontiers+in+medicine&rft.au=Herrmann%2C+Johannes&rft.au=Adam%2C+Elisabeth+Hannah&rft.au=Notz%2C+Quirin&rft.au=Helmer%2C+Philipp&rft.date=2020-12-18&rft.issn=2296-858X&rft.eissn=2296-858X&rft.volume=7&rft.spage=599533&rft_id=info:doi/10.3389%2Ffmed.2020.599533&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2296-858X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2296-858X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2296-858X&client=summon |