Neuromodulated Spike-Timing-Dependent Plasticity, and Theory of Three-Factor Learning Rules

Classical Hebbian learning puts the emphasis on joint pre- and postsynaptic activity, but neglects the potential role of neuromodulators. Since neuromodulators convey information about novelty or reward, the influence of neuromodulators on synaptic plasticity is useful not just for action learning i...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Frontiers in neural circuits Ročník 9; s. 85
Hlavní autori:	Frémaux, Nicolas, Gerstner, Wulfram
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Switzerland Frontiers Research Foundation 19.01.2016 Frontiers Media S.A
Predmet:	Action Potentials - physiology Animals Classical conditioning Dopamine Firing pattern Hebbian plasticity Humans Learning Learning - physiology Mathematical models Memory Models, Neurological Neural networks Neuromodulation Neuronal Plasticity - physiology Neurons Neurons - physiology Neuroscience plasticity Reinforcement Reward Learning Science Sensory stimuli STDP Success surprise Synaptic plasticity neuromodulation spiking neuron networks novelty reward learning plasticity synaptic plasticity (LTP/LTD) STDP
ISSN:	1662-5110, 1662-5110
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Popis
Shrnutí:	Classical Hebbian learning puts the emphasis on joint pre- and postsynaptic activity, but neglects the potential role of neuromodulators. Since neuromodulators convey information about novelty or reward, the influence of neuromodulators on synaptic plasticity is useful not just for action learning in classical conditioning, but also to decide "when" to create new memories in response to a flow of sensory stimuli. In this review, we focus on timing requirements for pre- and postsynaptic activity in conjunction with one or several phasic neuromodulatory signals. While the emphasis of the text is on conceptual models and mathematical theories, we also discuss some experimental evidence for neuromodulation of Spike-Timing-Dependent Plasticity. We highlight the importance of synaptic mechanisms in bridging the temporal gap between sensory stimulation and neuromodulatory signals, and develop a framework for a class of neo-Hebbian three-factor learning rules that depend on presynaptic activity, postsynaptic variables as well as the influence of neuromodulators.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 Reviewed by: Wolfgang Stein, Illinois State University, USA; Livia De Hoz, Max Planck Institute of Experimental Medicine, Germany Edited by: Ido Kanter, Bar Ilan University, Israel
ISSN:	1662-5110 1662-5110
DOI:	10.3389/fncir.2015.00085