Robust subdivision of the thalamus in children based on probability distribution functions calculated from probabilistic tractography

Virtually all information that enters the cortex must first pass through the thalamus. This prominent role has made the human thalamus a target for detailed imaging studies. It has previously been shown that probabilistic tractography together with cortical parcellation allowed subdivision of the th...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Vol. 57; no. 2; pp. 403 - 415
Main Authors: Broser, Philip, Vargha-Khadem, Faraneh, Clark, Chris A.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 15.07.2011
Elsevier Limited
Subjects:
Adolescent
Age
Algorithms
Anatomy, Artistic
Atlases as Topic
Brain
Brain Mapping - methods
Child
Diffusion Tensor Imaging
Distribution of probability of connectivity
Female
Females
Humans
Image Interpretation, Computer-Assisted - methods
Male
Neural Pathways - anatomy & histology
NMR
Nuclear magnetic resonance
Probabilistic diffusion tensor imaging
Probability
Ratios
Structural parcellation
Thalamic subdivison
Thalamus
Thalamus - anatomy & histology
Structural parcellation
PDF
CDV
Probabilistic diffusion tensor imaging
DPC
Distribution of probability of connectivity
DTI
MNI
Thalamus
Thalamic subdivison
ISSN:1053-8119, 1095-9572, 1095-9572
Online Access:Get full text
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Summary:Virtually all information that enters the cortex must first pass through the thalamus. This prominent role has made the human thalamus a target for detailed imaging studies. It has previously been shown that probabilistic tractography together with cortical parcellation allowed subdivision of the thalamus into its constituent substructures. A new method is presented that allows the subdivision of the thalamus according to its cortical projection targets based on the assumption that any cortical region receives input from the thalamus and calculates the probability of connectivity distribution functions based on probabilistic tractography. The feasibility of the method was tested in a data set of 43 healthy children aged between 8 and 13years. A thalamic parcellation pattern similar to that previously found in adults and children below the age of 2years was obtained. However, no evidence for an age related change in cortical parcellation volumes were found in line with previously reported studies of thalamic volumes during development. Lower standard deviations were found for the two smallest projections, the sensory and occipital projection using the new method. Furthermore it was found, through comparison with a published thalamic atlas, that the method allowed the localization of the center of the different thalamic projection areas within an accuracy of 2mm. [Display omitted] ► Robust analysis of the thalamic substructures by probabilistic tractography. ► Atlas of the thalamic substructures of children as revealed by tractography. ► Canocical normalization of the thalamo cortical projection pattern. ► Cortical Subdivision used for thalamic parcellation. ► Method to analyze the thalamus using single subject data.
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ISSN:1053-8119
1095-9572
1095-9572
DOI:10.1016/j.neuroimage.2011.04.054