Rampant C→U Hypermutation in the Genomes of SARS-CoV-2 and Other Coronaviruses: Causes and Consequences for Their Short- and Long-Term Evolutionary Trajectories

The wealth of accurately curated sequence data for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), its long genome, and its low substitution rate provides a relatively blank canvas with which to investigate effects of mutational and editing processes imposed by the host cell. The findi...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	mSphere Ročník 5; číslo 3
Hlavný autor:	Simmonds, P.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States American Society for Microbiology 24.06.2020
Predmet:	Amino acid sequence Antiretroviral drugs Antiviral drugs APOBEC APOBEC Deaminases Asymmetry Base Composition - genetics Base Sequence - genetics Betacoronavirus - genetics Coronaviridae coronavirus Coronavirus Infections - pathology Coronaviruses COVID-19 Cytidine Deaminase - genetics Cytosine - analysis Datasets Disease transmission Divergence Ecological and Evolutionary Science Epidemics Epidemiology Evolution Genome, Viral - genetics Genomes Humans hypermutation Long-term effects Mathematical models Middle East Respiratory Syndrome Coronavirus - genetics Molecular modelling Mutation Pandemics Pneumonia, Viral - pathology Polymorphism, Single Nucleotide - genetics Reversion RNA polymerase SARS SARS coronavirus 2 SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome-related coronavirus - genetics Uracil - analysis Zoonoses COVID-19 SARS-CoV-2 APOBEC SARS coronavirus SARS coronavirus 2 hypermutation
ISSN:	2379-5042, 2379-5042
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Buďte prvý, kto okomentuje tento záznam!