Basophil-derived IL-4 promotes epicutaneous antigen sensitization concomitant with the development of food allergy

Exaggerated thymic stromal lymphopoietin (TSLP) production and infiltration of basophils are associated with the pathogenesis of atopic dermatitis (AD), a recognized risk factor for the development of food allergies. Although TSLP and basophils have been implicated in promotion of food-induced aller...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 141; no. 1; pp. 223 - 234.e5
Main Authors:	Hussain, Maryam, Borcard, Loïc, Walsh, Kevin P., Pena Rodriguez, Maria, Mueller, Christoph, Kim, Brian S., Kubo, Masato, Artis, David, Noti, Mario
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.01.2018 Elsevier Limited
Subjects:	Allergens - immunology Allergy and Immunology Animals Antigens Asthma Atopic dermatitis basophils Basophils - immunology Basophils - metabolism Biomarkers Cell Communication - immunology Dendritic cells Dendritic Cells - immunology Dendritic Cells - metabolism Dermatitis Disease Models, Animal Eczema epicutaneous sensitization Food - adverse effects Food allergies Food Hypersensitivity - immunology Food Hypersensitivity - metabolism Gastrointestinal tract IgE IgE-mediated food allergy IL-4 Immunity, Innate Immunization Immunoglobulin E Immunoglobulin E - immunology Immunophenotyping Inflammation Interleukin 4 Interleukin-4 - metabolism Leukocytes (basophilic) Leukocytes (eosinophilic) Lymphocytes T mast cells Medical innovations Mice Mice, Transgenic Mucosa Ovalbumin Pathogenesis Polarization Skin diseases T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Th2 Cells - immunology Th2 Cells - metabolism TH2 polarization Thymic stromal lymphopoietin Thymus eGFP AD TSLP OX40L IgE IL-4 atopic dermatitis TH2 polarization IgE-mediated food allergy basophils mast cells ILC2 epicutaneous sensitization thymic stromal lymphopoietin OVA WT DC Dendritic cell Ovalbumin T H2 polarization Wild-type Group 2 innate lymphoid cell OX40 ligand Enhanced green fluorescent protein T(H)2 polarization
ISSN:	0091-6749, 1097-6825, 1097-6825
Online Access:	Get full text
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