Dietary hydrogenated fat increases high-density lipoprotein apoA-I catabolism and decreases low-density lipoprotein apoB-100 catabolism in hypercholesterolemic women

To determine mechanisms contributing to decreased high-density lipoprotein cholesterol (HDL-C) and increased low-density lipoprotein cholesterol (LDL-C) concentrations associated with hydrogenated fat intake, kinetic studies of apoA-I, apoB-100, and apoB-48 were conducted using stable isotopes. Eigh...

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Veröffentlicht in:Arteriosclerosis, thrombosis, and vascular biology Jg. 24; H. 6; S. 1092
Hauptverfasser: Matthan, Nirupa R, Welty, Francine K, Barrett, P Hugh R, Harausz, Carrie, Dolnikowski, Gregory G, Parks, John S, Eckel, Robert H, Schaefer, Ernst J, Lichtenstein, Alice H
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.06.2004
Schlagworte:
Apolipoprotein A-I - blood
Apolipoprotein B-100
Apolipoproteins B - blood
Butter
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Cross-Over Studies
Dietary Fats - pharmacology
Double-Blind Method
Female
Humans
Hypercholesterolemia - blood
Kinetics
Margarine
Middle Aged
Postmenopause
Soybean Oil - pharmacology
Trans Fatty Acids - pharmacology
Triglycerides - blood
ISSN:1524-4636, 1524-4636
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Zusammenfassung:To determine mechanisms contributing to decreased high-density lipoprotein cholesterol (HDL-C) and increased low-density lipoprotein cholesterol (LDL-C) concentrations associated with hydrogenated fat intake, kinetic studies of apoA-I, apoB-100, and apoB-48 were conducted using stable isotopes. Eight postmenopausal hypercholesterolemic women were provided in random order with 3 diets for 5-week periods. Two-thirds of the fat was soybean oil (unsaturated fat), stick margarine (hydrogenated fat), or butter (saturated fat). Total and LDL-C levels were highest after the saturated diet (P<0.05; saturated versus unsaturated) whereas HDL-C levels were lowest after the hydrogenated diet (P<0.05; hydrogenated versus saturated). Plasma apoA-I levels and pool size (PS) were lower, whereas apoA-I fractional catabolic rate (FCR) was higher after the hydrogenated relative to the saturated diet (P<0.05). LDL apoB-100 levels and PS were significantly higher, whereas LDL apoB-100 FCR was lower with the saturated and hydrogenated relative to the unsaturated diet. There was no significant difference among diets in apoA-I or B-100 production rates or apoB-48 kinetic parameters. HDL-C concentrations were negatively associated with apoA-I FCR (r=-0.56, P=0.03) and LDL-C concentrations were negatively correlated with LDL apoB-100 FCR (r=-0.48, P=0.05). The mechanism for the adverse lipoprotein profile observed with hydrogenated fat intake is determined in part by increased apoA-I and decreased LDL apoB-100 catabolism.
Bibliographie:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1524-4636
1524-4636
DOI:10.1161/01.atv.0000128410.23161.be