Optimized signal peptides for the development of high expressing CHO cell lines

Recombinant biotherapeutic proteins such as monoclonal antibodies are mostly produced in Chinese hamster ovary (CHO) cells and pharmaceutical companies are interested in an appropriate platform technology for the development of large‐scale production processes. A major aim of our study was therefore...

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Bibliographic Details
Published in:	Biotechnology and bioengineering Vol. 110; no. 4; pp. 1164 - 1173
Main Authors:	Kober, Lars, Zehe, Christoph, Bode, Juergen
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2013 Wiley Subscription Services, Inc
Subjects:	Amino Acid Sequence Animals cell-specific productivity Cells Chinese hamster ovary (CHO) CHO Cells Chromatography, High Pressure Liquid Cricetinae Cricetulus fed batch Gaussia Genetic Vectors high productive Molecular Sequence Data Molecules Monoclonal antibodies Peptides Pharmaceutical industry Protein Sorting Signals Proteins recombinant antibody Rodents signal peptide Transfection Vargula
ISSN:	0006-3592, 1097-0290, 1097-0290
Online Access:	Get full text
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