Optimized signal peptides for the development of high expressing CHO cell lines

Recombinant biotherapeutic proteins such as monoclonal antibodies are mostly produced in Chinese hamster ovary (CHO) cells and pharmaceutical companies are interested in an appropriate platform technology for the development of large‐scale production processes. A major aim of our study was therefore...

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Vydáno v:	Biotechnology and bioengineering Ročník 110; číslo 4; s. 1164 - 1173
Hlavní autoři:	Kober, Lars, Zehe, Christoph, Bode, Juergen
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2013 Wiley Subscription Services, Inc
Témata:	Amino Acid Sequence Animals cell-specific productivity Cells Chinese hamster ovary (CHO) CHO Cells Chromatography, High Pressure Liquid Cricetinae Cricetulus fed batch Gaussia Genetic Vectors high productive Molecular Sequence Data Molecules Monoclonal antibodies Peptides Pharmaceutical industry Protein Sorting Signals Proteins recombinant antibody Rodents signal peptide Transfection Vargula
ISSN:	0006-3592, 1097-0290, 1097-0290
On-line přístup:	Získat plný text
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