MDS research criteria for prodromal Parkinson's disease

ABSTRACT This article describes research criteria and probability methodology for the diagnosis of prodromal PD. Prodromal disease refers to the stage wherein early symptoms or signs of PD neurodegeneration are present, but classic clinical diagnosis based on fully evolved motor parkinsonism is not...

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Vydáno v:Movement disorders Ročník 30; číslo 12; s. 1600 - 1611
Hlavní autoři: Berg, Daniela, Postuma, Ronald B., Adler, Charles H., Bloem, Bastiaan R., Chan, Piu, Dubois, Bruno, Gasser, Thomas, Goetz, Christopher G., Halliday, Glenda, Joseph, Lawrence, Lang, Anthony E., Liepelt-Scarfone, Inga, Litvan, Irene, Marek, Kenneth, Obeso, José, Oertel, Wolfgang, Olanow, C. Warren, Poewe, Werner, Stern, Matthew, Deuschl, Günther
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Blackwell Publishing Ltd 01.10.2015
Wiley Subscription Services, Inc
Témata:
diagnosis
Humans
Movement disorders
Parkinson Disease - diagnosis
Parkinson's disease
prodromal
Prodromal Symptoms
Severity of Illness Index
Societies, Scientific - standards
diagnosis
prodromal
Parkinson's disease
ISSN:0885-3185, 1531-8257, 1531-8257
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Shrnutí:ABSTRACT This article describes research criteria and probability methodology for the diagnosis of prodromal PD. Prodromal disease refers to the stage wherein early symptoms or signs of PD neurodegeneration are present, but classic clinical diagnosis based on fully evolved motor parkinsonism is not yet possible. Given the lack of clear neuroprotective/disease‐modifying therapy for prodromal PD, these criteria were developed for research purposes only. The criteria are based upon the likelihood of prodromal disease being present with probable prodromal PD defined as ≥80% certainty. Certainty estimates rely upon calculation of an individual's risk of having prodromal PD, using a Bayesian naïve classifier. In this methodology, a previous probability of prodromal disease is delineated based upon age. Then, the probability of prodromal PD is calculated by adding diagnostic information, expressed as likelihood ratios. This diagnostic information combines estimates of background risk (from environmental risk factors and genetic findings) and results of diagnostic marker testing. In order to be included, diagnostic markers had to have prospective evidence documenting ability to predict clinical PD. They include motor and nonmotor clinical symptoms, clinical signs, and ancillary diagnostic tests. These criteria represent a first step in the formal delineation of early stages of PD and will require constant updating as more information becomes available. © 2015 International Parkinson and Movement Disorder Society
Bibliografie:istex:E9C5D6E8CEA0F5DC3C6D81B4088BB0FB2EDA18F9
ark:/67375/WNG-PD07W02Z-S
ArticleID:MDS26431
Full financial disclosures and author roles may be found in the online version of this article.
Nothing to report.
Drs. Berg and Postuma contributed equally.
Relevant conflicts of interest/financial disclosures
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ISSN:0885-3185
1531-8257
1531-8257
DOI:10.1002/mds.26431