Particle Counting Methods Based on Microfluidic Devices

Particle counting serves as a pivotal constituent in diverse analytical domains, encompassing a broad spectrum of entities, ranging from blood cells and bacteria to viruses, droplets, bubbles, wear debris, and magnetic beads. Recent epochs have witnessed remarkable progressions in microfluidic chip...

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Published in:Micromachines (Basel) Vol. 14; no. 9; p. 1722
Main Authors: Dang, Zenglin, Jiang, Yuning, Su, Xin, Wang, Zhihao, Wang, Yucheng, Sun, Zhe, Zhao, Zheng, Zhang, Chi, Hong, Yuming, Liu, Zhijian
Format: Journal Article
Language:English
Published: Basel MDPI AG 01.09.2023
MDPI
Subjects:
Biomarkers
Biosensors
Blood cells
E coli
Light
Methods
Microfluidic devices
Microfluidics
Microscopy
particle counting
Physical properties
Principles
Progressions
Quantum dots
Radiation
Radiation counters
Review
Semiconductors
sensitivity
Sensitivity enhancement
throughput
Wear particles
ISSN:2072-666X, 2072-666X
Online Access:Get full text
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Summary:Particle counting serves as a pivotal constituent in diverse analytical domains, encompassing a broad spectrum of entities, ranging from blood cells and bacteria to viruses, droplets, bubbles, wear debris, and magnetic beads. Recent epochs have witnessed remarkable progressions in microfluidic chip technology, culminating in the proliferation and maturation of microfluidic chip-based particle counting methodologies. This paper undertakes a taxonomical elucidation of microfluidic chip-based particle counters based on the physical parameters they detect. These particle counters are classified into three categories: optical-based counters, electrical-based particle counters, and other counters. Within each category, subcategories are established to consider structural differences. Each type of counter is described not only in terms of its working principle but also the methods employed to enhance sensitivity and throughput. Additionally, an analysis of future trends related to each counter type is provided.
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Current address: Guangzhou Foreign Language School, Guangzhou 511455, China.
ISSN:2072-666X
2072-666X
DOI:10.3390/mi14091722