Effect of prostaglandin analogues on anterior scleral thickness and corneal thickness in patients with primary open-angle glaucoma

Prostaglandin (PG) analogues are usually prescribed as a first-line therapy in patients with glaucoma because of its once-daily dosing benefit and effective intraocular pressure (IOP) reduction. However, the mechanism of PG analogues is not completely understood. In this study, we investigated the e...

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Bibliographic Details
Published in:Scientific reports Vol. 11; no. 1; pp. 11098 - 8
Main Authors: Park, Ji-Hye, Yoo, Chungkwon, Chung, Hyun Woo, Kim, Yong Yeon
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 27.05.2021
Nature Portfolio
Subjects:
692/699/3161/3169/3170
692/699/3161/3172
Humanities and Social Sciences
multidisciplinary
Science
Science (multidisciplinary)
ISSN:2045-2322, 2045-2322
Online Access:Get full text
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Summary:Prostaglandin (PG) analogues are usually prescribed as a first-line therapy in patients with glaucoma because of its once-daily dosing benefit and effective intraocular pressure (IOP) reduction. However, the mechanism of PG analogues is not completely understood. In this study, we investigated the effect of PG analogues on the anterior scleral thickness (AST) in treatment-naïve eyes with primary open-angle glaucoma using anterior segment optical coherence tomography. The AST was measured at the location of the scleral spur, 1000 μm, and 2000 μm posterior to the scleral spur and was compared before and after using the medications for 3 months and 1 year. Among 54 patients enrolled in this study, 31 patients used prostaglandin analogues and 23 patients used dorzolamide/timolol fixed combination (DTFC) drugs. There was no significant difference in untreated IOP, glaucoma severity, and baseline AST values between the two groups. While there was no significant changes in AST after using the DTFC drugs, the AST at all 3 locations showed a significant reduction in both the nasal and temporal sectors after using PG analogues for 1 year (all, P  < 0.05). These findings suggest that the AST reduction after using PG analogues might be related with the increased uveoscleral outflow.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-90696-4