Robust cellular reprogramming occurs spontaneously during liver regeneration

Cellular reprogramming-the ability to interconvert distinct cell types with defined factors-is transforming the field of regenerative medicine. However, this phenomenon has rarely been observed in vivo without exogenous factors. Here, we report that activation of Notch, a signaling pathway that medi...

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Veröffentlicht in:	Genes & development Jg. 27; H. 7; S. 719
Hauptverfasser:	Yanger, Kilangsungla, Zong, Yiwei, Maggs, Lara R, Shapira, Suzanne N, Maddipati, Ravi, Aiello, Nicole M, Thung, Swan N, Wells, Rebecca G, Greenbaum, Linda E, Stanger, Ben Z
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.04.2013
Schlagworte:	Animals Cell Lineage Epithelial Cells - cytology Epithelial Cells - metabolism Hepatocytes - cytology Hepatocytes - metabolism Liver Regeneration - physiology Mice Receptors, Notch - metabolism Signal Transduction Stem Cells - cytology
ISSN:	1549-5477, 1549-5477
Online-Zugang:	Weitere Angaben
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