Robust cellular reprogramming occurs spontaneously during liver regeneration

Cellular reprogramming-the ability to interconvert distinct cell types with defined factors-is transforming the field of regenerative medicine. However, this phenomenon has rarely been observed in vivo without exogenous factors. Here, we report that activation of Notch, a signaling pathway that medi...

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Vydáno v:Genes & development Ročník 27; číslo 7; s. 719
Hlavní autoři: Yanger, Kilangsungla, Zong, Yiwei, Maggs, Lara R, Shapira, Suzanne N, Maddipati, Ravi, Aiello, Nicole M, Thung, Swan N, Wells, Rebecca G, Greenbaum, Linda E, Stanger, Ben Z
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.04.2013
Témata:
Animals
Cell Lineage
Epithelial Cells - cytology
Epithelial Cells - metabolism
Hepatocytes - cytology
Hepatocytes - metabolism
Liver Regeneration - physiology
Mice
Receptors, Notch - metabolism
Signal Transduction
Stem Cells - cytology
ISSN:1549-5477, 1549-5477
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Shrnutí:Cellular reprogramming-the ability to interconvert distinct cell types with defined factors-is transforming the field of regenerative medicine. However, this phenomenon has rarely been observed in vivo without exogenous factors. Here, we report that activation of Notch, a signaling pathway that mediates lineage segregation during liver development, is sufficient to reprogram hepatocytes into biliary epithelial cells (BECs). Moreover, using lineage tracing, we show that hepatocytes undergo widespread hepatocyte-to-BEC reprogramming following injuries that provoke a biliary response, a process requiring Notch. These results provide direct evidence that mammalian regeneration prompts extensive and dramatic changes in cellular identity under injury conditions.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1549-5477
1549-5477
DOI:10.1101/gad.207803.112