Distinctive properties of metastasis-initiating cells

Primary tumors are known to constantly shed a large number of cancer cells into systemic dissemination, yet only a tiny fraction of these cells is capable of forming overt metastases. The tremendous rate of attrition during the process of metastasis implicates the existence of a rare and unique popu...

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Bibliographic Details
Published in:Genes & development Vol. 30; no. 8; p. 892
Main Authors: Celià-Terrassa, Toni, Kang, Yibin
Format: Journal Article
Language:English
Published: United States 15.04.2016
Subjects:
Animals
Anoikis
Drug Resistance, Neoplasm
Epithelial-Mesenchymal Transition
Humans
Neoplasm Metastasis - physiopathology
Neoplasms - metabolism
Neoplasms - physiopathology
Neoplastic Stem Cells - pathology
epithelial–mesenchymal transition
metastasis-initiating cells
plasticity
metastatic niche
cancer metastasis
ISSN:1549-5477, 1549-5477
Online Access:Get more information
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Summary:Primary tumors are known to constantly shed a large number of cancer cells into systemic dissemination, yet only a tiny fraction of these cells is capable of forming overt metastases. The tremendous rate of attrition during the process of metastasis implicates the existence of a rare and unique population of metastasis-initiating cells (MICs). MICs possess advantageous traits that may originate in the primary tumor but continue to evolve during dissemination and colonization, including cellular plasticity, metabolic reprogramming, the ability to enter and exit dormancy, resistance to apoptosis, immune evasion, and co-option of other tumor and stromal cells. Better understanding of the molecular and cellular hallmarks of MICs will facilitate the development and deployment of novel therapeutic strategies.
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ISSN:1549-5477
1549-5477
DOI:10.1101/gad.277681.116