Distinctive properties of metastasis-initiating cells

Primary tumors are known to constantly shed a large number of cancer cells into systemic dissemination, yet only a tiny fraction of these cells is capable of forming overt metastases. The tremendous rate of attrition during the process of metastasis implicates the existence of a rare and unique popu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Genes & development Jg. 30; H. 8; S. 892
Hauptverfasser: Celià-Terrassa, Toni, Kang, Yibin
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 15.04.2016
Schlagworte:
Animals
Anoikis
Drug Resistance, Neoplasm
Epithelial-Mesenchymal Transition
Humans
Neoplasm Metastasis - physiopathology
Neoplasms - metabolism
Neoplasms - physiopathology
Neoplastic Stem Cells - pathology
epithelial–mesenchymal transition
metastasis-initiating cells
plasticity
metastatic niche
cancer metastasis
ISSN:1549-5477, 1549-5477
Online-Zugang:Weitere Angaben
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Primary tumors are known to constantly shed a large number of cancer cells into systemic dissemination, yet only a tiny fraction of these cells is capable of forming overt metastases. The tremendous rate of attrition during the process of metastasis implicates the existence of a rare and unique population of metastasis-initiating cells (MICs). MICs possess advantageous traits that may originate in the primary tumor but continue to evolve during dissemination and colonization, including cellular plasticity, metabolic reprogramming, the ability to enter and exit dormancy, resistance to apoptosis, immune evasion, and co-option of other tumor and stromal cells. Better understanding of the molecular and cellular hallmarks of MICs will facilitate the development and deployment of novel therapeutic strategies.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1549-5477
1549-5477
DOI:10.1101/gad.277681.116