Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease

To define copy number alterations and gene expression signatures underlying pediatric high-grade glioma (HGG). We conducted a high-resolution analysis of genomic imbalances in 78 de novo pediatric HGGs, including seven diffuse intrinsic pontine gliomas, and 10 HGGs arising in children who received c...

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Veröffentlicht in:	Journal of clinical oncology Jg. 28; H. 18; S. 3061
Hauptverfasser:	Paugh, Barbara S, Qu, Chunxu, Jones, Chris, Liu, Zhaoli, Adamowicz-Brice, Martyna, Zhang, Junyuan, Bax, Dorine A, Coyle, Beth, Barrow, Jennifer, Hargrave, Darren, Lowe, James, Gajjar, Amar, Zhao, Wei, Broniscer, Alberto, Ellison, David W, Grundy, Richard G, Baker, Suzanne J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 20.06.2010
Schlagworte:	Adolescent Adult Biomarkers, Tumor - genetics Brain Neoplasms - genetics Brain Neoplasms - pathology Child Child, Preschool Chromosomes, Human, Pair 1 - genetics Cranial Irradiation Gene Expression Profiling Glioma - genetics Glioma - pathology Humans Infant Oligonucleotide Array Sequence Analysis Polymorphism, Single Nucleotide - genetics Prognosis Receptor, Platelet-Derived Growth Factor alpha - genetics Young Adult
ISSN:	1527-7755, 1527-7755
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