Specific defect in N-acetylglucosamine incorporation in the biosynthesis of the glycosylphosphatidylinositol anchor in cloned cell lines from patients with paroxysmal nocturnal hemoglobinuria

Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal disorder arising in a multipotent hemopoietic stem cell. PNH manifests clinically with intravascular hemolysis resulting from an increased sensitivity of the red cells belonging to the PNH clone to complement-mediated lysis. Numerous studies have...

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Vydáno v:	Proceedings of the National Academy of Sciences - PNAS Ročník 90; číslo 11; s. 5272
Hlavní autoři:	Hillmen, P, Bessler, M, Mason, P J, Watkins, W M, Luzzatto, L
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.06.1993
Témata:	Acetylglucosamine - metabolism Adult Carbohydrate Conformation Carbohydrate Sequence Cell Line Cell Line, Transformed Cell-Free System Chromatography, Thin Layer Clone Cells Female Glycosylphosphatidylinositols - biosynthesis Hemoglobinuria, Paroxysmal - metabolism Herpesvirus 4, Human - genetics Humans Inositol - metabolism Lymphocytes - metabolism Male Mannose - metabolism Middle Aged Molecular Sequence Data Tritium Uridine Diphosphate N-Acetylglucosamine - metabolism
ISSN:	0027-8424
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