A randomized and blinded multicenter trial of high-dose fluconazole plus placebo versus fluconazole plus amphotericin B as therapy for candidemia and its consequences in nonneutropenic subjects

A randomized, blinded, multicenter trial was conducted to compare fluconazole (800 mg per day) plus placebo with fluconazole plus amphotericin B (AmB) deoxycholate (0.7 mg/kg per day, with the placebo/AmB component given only for the first 5-6 days) as therapy for candidemia due to species other tha...

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Veröffentlicht in:	Clinical infectious diseases Jg. 36; H. 10; S. 1221
Hauptverfasser:	Rex, John H, Pappas, Peter G, Karchmer, Adolf W, Sobel, Jack, Edwards, John E, Hadley, Susan, Brass, Corstiaan, Vazquez, Jose A, Chapman, Stanley W, Horowitz, Harold W, Zervos, Marcus, McKinsey, David, Lee, Jeannette, Babinchak, Timothy, Bradsher, Robert W, Cleary, John D, Cohen, David M, Danziger, Larry, Goldman, Mitchell, Goodman, Jesse, Hilton, Eileen, Hyslop, Newton E, Kett, Daniel H, Lutz, Jon, Rubin, Robert H, Scheld, W Michael, Schuster, Mindy, Simmons, Bryan, Stein, David K, Washburn, Ronald G, Mautner, Linda, Chu, Teng-Chiao, Panzer, Helene, Rosenstein, Rebecca B, Booth, Jenia
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.05.2003
Schlagworte:	Adult Amphotericin B - adverse effects Amphotericin B - therapeutic use Antifungal Agents - adverse effects Antifungal Agents - therapeutic use Candida - drug effects Candidiasis - drug therapy Candidiasis - physiopathology Catheterization Double-Blind Method Drug Therapy, Combination Female Fluconazole - adverse effects Fluconazole - therapeutic use Fungemia - drug therapy Fungemia - physiopathology Humans Male Middle Aged Neutropenia - etiology Treatment Outcome
ISSN:	1537-6591, 1537-6591
Online-Zugang:	Weitere Angaben
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